- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01197924
MEDIR Medulloblastome (MEDIR)
Médulloblastome of the Child and After-effects Cognitive: Study Anatomo-functional by IRM of the Working Memory
The medulloblastome is a tumour of the child relatively frequent usually sitting in the cerebellum and treated by surgery, radiotherapy and chemotherapy. After the treatment, these children present cognitive disorders and in particular disorders of the working memory associated with a fall with the school performances. By studying a troop of 32 children, we could show that the disorders of the working memory prevail during the handling of information presented visually and with verbal contents. However, the specific engagement of the cerebellum in the tasks of working memory according to the sensory method of presentation (visual or auditive) and the nature (verbal or not verbal) of information to treat vague remainder. Moreover, the anatomical attacks associated with these disorders remain ignored in these children. The best comprehension of the bases anatomo-functional calculuses which underlie their cognitive deficits is essential to develop new strategies of treatment and rehabilitation.
Objectives:
- To describe in IRMf of the common and specific networks engaged during the execution of the tasks of working memory according to the sensory type and the nature of information to be memorized.
- To describe in IRMf the cortical reorganizations necessary to the execution of the mnemic tasks among patients.
- To describe in anatomical IRM and of the tensor of diffusion lesions cérébelleuses and cerebral, cortical and subcortical associated with these disorders.
- To study the correlations radio-private clinics between data IRM and the data neurological and neuropsychological of the children explored according to protocol ONCORAP
Study Overview
Detailed Description
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Isabelle I SCHIFF
- Phone Number: 0476762635
- Email: ISchiff@chu-grenoble.fr
Study Locations
-
-
-
Bordeaux, France, 33076
- Recruiting
- University Hospital
-
Sub-Investigator:
- Michèle M ALLARD
-
Sub-Investigator:
- Céline C BOUCHN ICHER
-
Sub-Investigator:
- Muriel M BRUN
-
Sub-Investigator:
- Anne A NOTZ CARRERE
-
Sub-Investigator:
- Yves y PEREL
-
Grenoble, France, 38043
- Recruiting
- UniversityHospitalGrenoble
-
Contact:
- Isabelle I SCHIFF
- Email: ISchiff@chu-grenoble.fr
-
Sub-Investigator:
- Alexandre A KRAINIK
-
Sub-Investigator:
- Dominique D PLANTAZ
-
Sub-Investigator:
- Corinne C ARAMARI ALLA
-
Sub-Investigator:
- FANNY F DUBOIS
-
Sub-Investigator:
- CHANTAL C DURAND
-
Lyon, France, 69008
- Recruiting
- Institut D'Hematologie Et D'Oncologie Pediatrique
-
Sub-Investigator:
- Cécile c CONTER
-
Sub-Investigator:
- DIDIER D FRAPPAZ
-
Paris, France, 75015
- Recruiting
- Hôpital Frédéric Joliot Orsay - Hôpital Necker
-
Sub-Investigator:
- Lucie L HERTZ PANNIER
-
Sub-Investigator:
- Rodrigo R SEBASTIAN
-
Paris, France, 75231
- Recruiting
- Institut Curie
-
Sub-Investigator:
- Isabelle i AERTS
-
Sub-Investigator:
- François F DOZ
-
Sub-Investigator:
- Sylvie S FASOLA
-
Sub-Investigator:
- Jean J MICHON
-
Sub-Investigator:
- Daniel D ORBACH
-
Sub-Investigator:
- Hélène H PACQUEMENT
-
Sub-Investigator:
- GILLES G PALENZUELA
-
Sub-Investigator:
- GUDRUN G SCHLEIERMACHER
-
Saint Etienne, France, 42055
- Recruiting
- University Hospital
-
Sub-Investigator:
- CLAIRE C BERGER
-
Sub-Investigator:
- FABRICE F BARRAL
-
Sub-Investigator:
- CATHERINE C MASSOUBRE
-
Sub-Investigator:
- JEAN LOUIS JL STEPHAN
-
Villejuif, France, 94805
- Recruiting
- Institut Gutave Roussy
-
Sub-Investigator:
- jacques j Grill
-
Villeurbanne, France, 69100
- Recruiting
- SMAEC
-
Sub-Investigator:
- Sybille S GONZALEZ
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Old from 8 to 12 years
- Total IQ > 70 for the participation in the study and/or age développemental 7 years minimum
- Treaties for a médulloblastome after the 6 years age in remission supplements with 6 months a minimum time compared to the end of all the treatments
- Followed within the framework of the protocol of evaluation of the mnemic and attentionnelles after-effects
- Sensory after-effects compatible with the realization of the tasks and good performances at the time of the preceding drive the IRM
- Absence of counter-indication to the IRM
- Absence of catch of méthylphénidate (Ritaline®) for the treatment of disorders attentionnels 48h before the IRM
- Enlightened assent signed by at least one of the two parents or holders of the parental authority and by the child (minor)
Exclusion Criteria:
- Agitation or movements of the head at the time the IRM
- Artifacts of magnetic susceptibility in projection of the areas of interest (intracranial haemorrhage, cortical and/or metal remains post-operative) • Bad execution of the cognitive tasks
- Tumoral relapse in the course of protocol
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
healthy volonteer children
paired for the sex and the age
|
IRMf BOLD of the working memory
|
older children followed for a médulloblastome cérébelleux
children followed for a médulloblastome treaty by surgery, radiotherapy and chemotherapy
|
IRMf BOLD of the working memory
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Anne A PAGNIER, Doctor, University Hospital, Grenoble
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- 07PHN01
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Child Cancer Brain
-
The Hong Kong Polytechnic UniversityNot yet recruitingMuscular Atrophy | Child With Cancer | Child With Cerebral Palsy | Child With Medical Complexity
-
Gazi UniversityNot yet recruitingCancer | Child, Only | Empowerment
-
Gazi UniversityNot yet recruitingCancer | Parents | Child, Only | EmpowermentTurkey
-
University of California, IrvineEunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaboratorsActive, not recruitingChild Development | Brain Development | Household and Family ProcessesUnited States
-
Corey HawesNational Center for Advancing Translational Sciences (NCATS)RecruitingPediatric Cancer | Nutrition Aspect of Cancer | Muscle Loss | Malnutrition, Child | Nutrition Related CancerUnited States
-
University Hospital, Clermont-FerrandUniversité d'AuvergneUnknownCancer | Child | Qualitative Research | Determinants of HealthFrance
-
UNC Lineberger Comprehensive Cancer CenterNational Cancer Institute (NCI); National Institute of Allergy and Infectious...CompletedNeoplasms | Cancer | Communication | Parent-Child Relations | Parenting | ParentsUnited States
-
Memorial Sloan Kettering Cancer CenterNational Cancer Institute (NCI); Dana-Farber Cancer Institute; University of... and other collaboratorsActive, not recruitingParents Who Have Lost a Child to CancerUnited States
-
UNC Lineberger Comprehensive Cancer CenterCompletedNeoplasms | Cancer | Communication | Parent-Child Relations | Parenting | ParentsUnited States
-
School of Health Sciences GenevaUniversity of Lausanne Hospitals; University of Geneva, SwitzerlandRecruitingMagnetic Resonance Imaging | Behavior | Functional Magnetic Resonance Imaging | Music | Development, Child | Brain Imaging | Executive Functions | Brain Plasticity | Interventions | Arts | Structural Brain ConnectivitySwitzerland
Clinical Trials on IRMf Bold
-
University Hospital, ToulouseCompleted
-
Penn State UniversityNational Cattlemen's Beef AssociationCompletedHypercholesterolemia | Hypertriglyceridemia
-
Fondation Ophtalmologique Adolphe de RothschildRecruitingVision Functional Brain Networks in Patients With Hereditary Retinal DystrophiesFrance
-
Assistance Publique - Hôpitaux de ParisCompletedIntrauterine Growth RestrictionFrance
-
Samsung Medical CenterNational Research Foundation of KoreaUnknown
-
Zimmer BiometCompletedPeripheral Arterial Disease | Critical Limb IschemiaUnited States
-
University Hospital Inselspital, BerneActive, not recruitingKidney Transplantation | Urinary CalculiSwitzerland
-
Hospices Civils de LyonCompleted
-
Penn State UniversityNational Cattlemen's Beef AssociationCompletedCardiovascular Disease | Metabolic SyndromeUnited States
-
National Institute on Aging (NIA)Completed