Comparison of Anterior Chamber Paracentesis and Conventional Mannitol Infusion in Patients With Primary Acute Angle-closure Glaucoma

The investigators wanted to reported the results of immediate anterior chamber paracentesis (ACP), compared to Mannitol infusion, in patients with acute primary angle-closure glaucoma (PACG). In this study, the investigators first divided patients into three sub-groups according to their initial intraocular pressure (IOP) for analyzing the differences of IOP control, severity of corneal edema, waiting time for laser peripheral iridotomy (LPI), and visual outcome between ACP and Mannitol infusion.

Study Overview

• Status: Completed
• Conditions: Glaucoma; Acute Primary Angle-closure Glaucoma

Detailed Description

The investigators demonstrated that ACP could be first considered in patients with initial IOP between 45 to 60 mmHg because it provided better visual outcome than Mannitol infusion through the rapid stabilization of the anterior segment, which was achieved by rapid IOP control, better corneal edema regression, shortening waiting time for LPI. However, ACP should be considered in patients with the initial IOP of 60mmHg and higher only when Mannitol was contraindicated.

• Study Type: Observational
• Enrollment (Actual): 60

Contacts and Locations

Study Locations

• Taiwan
  • Taipei, Taiwan
    • Taipei Medical University - WanFang Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

Glaucoma patients

Description

Inclusion Criteria:

• first attack of acute PACG;
• initial presenting IOP was higher than 45 mmHg;
• diagnosis confirmed by gonioscopic examination;
• patients within 48 hours of symptom onset.

Exclusion Criteria:

• been incompletely followed up within 2 weeks;
• been using anti-glaucomatous medication before ACP or Mannitol infusion;
• previous intraocular surgeries on the same eye;
• contraindication for Mannitol;
• history of other vision-threatening ocular diseases.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
Control Group
Experimental Group

Collaborators and Investigators

• Sponsor: Taipei Medical University WanFang Hospital

Study record dates

Study Major Dates

• Study Start: January 1, 2007
• Study Completion (ACTUAL): December 1, 2009

Study Registration Dates

• First Submitted: December 22, 2010
• First Submitted That Met QC Criteria: December 23, 2010
• First Posted (ESTIMATE): December 24, 2010

Study Record Updates

• Last Update Posted (ESTIMATE): December 24, 2010
• Last Update Submitted That Met QC Criteria: December 23, 2010
• Last Verified: December 1, 2010

More Information

Terms related to this study

• Keywords: Glaucoma; anterior chamber paracentesis; conventional Mannitol infusion
• Additional Relevant MeSH Terms: Eye Diseases; Ocular Hypertension; Glaucoma; Glaucoma, Angle-Closure
• Other Study ID Numbers: 99018