- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01295801
Vitamin B6 on Relieving Linezolid-associated Cytopenias
February 14, 2011 updated by: Chinese PLA General Hospital
The Effects and Mechanism of Vitamin B6 on Relieving Linezolid-associated Cytopenias
Linezolid is the first approved synthetic oxazolidinone that is active against multidrug-resistant Gram-positive pathogens.
Because of its significant efficacy, linezolid is widely used in clinical treatment.
However, the side effects of linezolid commonly lead to anemia and thrombocytopenia.
This hematological toxic effects limit its prolonged used.
The investigators have found that Vitamin B6 application, as a preventive, auxiliary therapy, can relieve anemia and thrombocytopenia.
The present study was designed to verify the effects of Vitamin B6 in the prevention of linezolid-associated cytopenias and investigate its mechanism.
Study Overview
Status
Unknown
Conditions
Detailed Description
Infected patients receiving linezolid therapy are divided into two groups, i.e. the linezolid group and the linezolid + vitamin B6 group, the line of division being whether vitamin B6 is to be applied or not in the course of treatment.
The purpose is to evaluate the role that vitamin B6 plays, during the process of linezolid therapy, in the relief of erythropenia and cytopenias.
Study Type
Observational
Enrollment (Anticipated)
80
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Beijing
-
Beijing, Beijing, China, 100853
- Recruiting
- Chinese PLA General Hospital
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
Use of linezolid
Description
Inclusion Criteria:
- Use of linezolid is not less than 3 days
Exclusion Criteria:
- Serious adverse reactions
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Observational Models: Case-Control
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
---|
Linezolid+vitamin B6
|
Linezolid
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Director: Xie Lixin, Doctor, Pneumology Department of chinese PLA General Hospital
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
November 1, 2010
Primary Completion (Anticipated)
July 1, 2011
Study Completion (Anticipated)
September 1, 2011
Study Registration Dates
First Submitted
February 14, 2011
First Submitted That Met QC Criteria
February 14, 2011
First Posted (Estimate)
February 15, 2011
Study Record Updates
Last Update Posted (Estimate)
February 15, 2011
Last Update Submitted That Met QC Criteria
February 14, 2011
Last Verified
October 1, 2010
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 301PLAGH-20101027001
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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