Differences in Nerve Fiber Layer Between Patients With Normal- and High-Pressure-Glaucoma

Differences in Nerve Fiber Layer Between Patients With Normal- and High-Pressure-Glaucoma With Similar Structural Optic Nerve Damage

The purpose of the study is to prove if there is any difference in the nerve fiber layer between patients with normal- and high-tension-glaucoma with similar structural optic nerve head parameters.

Study Overview

• Status: Completed
• Conditions: Normal Tension Glaucoma; High Tension Glaucoma

Detailed Description

It is till now not definitely clear whether normal- and high-tension glaucoma are different forms of the same disease and whether they have similar pathogenetic mechanisms. Spectral domain optical coherence tomography (SD-OCT) is supposed to objectively evaluate retinal nerve fiber layer (RNFL) thickness. The investigators propose a study to compare the RNFL in patients with normal- and high-tension-glaucoma. In order to exclude other possible differences,which could influence the results, only patients with similar structural optic nerve head damage in both groups will be compared.

• Study Type: Observational
• Enrollment (Actual): 44

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 60 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

primary care clinic University hospital of Dresden

Description

Inclusion Criteria:

• persons over 18 years
• men or women
• with normal- and high-tension glaucoma

Exclusion Criteria:

• cataract
• cloudy cornea and other conditions with bad visualisation quality of optic nerve head
• optic nerve atrophy except glaucomatous

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort
high-tension glaucoma; subjects with IOP>22 mmHg without eyedrops and signs of glaucomatous optic nerve damage
low-tension glaucoma; subjects with IOP<22 mmHg without eyedrops and signs of glaucomatous optic nerve damage

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
RNFL in different segments	RNFL in upper, lower, temporal and nasal segments	up to 9 Months

Collaborators and Investigators

• Sponsor: Technische Universität Dresden

Study record dates

Study Major Dates

• Study Start: March 1, 2011
• Primary Completion (Actual): November 1, 2011
• Study Completion (Actual): November 1, 2011

Study Registration Dates

• First Submitted: December 1, 2011
• First Submitted That Met QC Criteria: December 7, 2011
• First Posted (Estimate): December 8, 2011

Study Record Updates

• Last Update Posted (Estimate): December 9, 2011
• Last Update Submitted That Met QC Criteria: December 8, 2011
• Last Verified: December 1, 2011

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Eye Diseases; Ocular Hypertension; Optic Nerve Diseases; Glaucoma; Low Tension Glaucoma
• Other Study ID Numbers: EK 322102010