- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01568580
Efficacy and Safety of Recombinant Factor VIII (GreenGene) in Patients With Hemophilia A
March 29, 2012 updated by: Green Cross Corporation
Open-label, Non-comparative, Multicenter, Phase III for Evaluation of Efficacy and Safety of Recombinant Factor VIII (GreenGene) in Previously Treated Patients With Hemophilia A
The purpose of this study is to study the evaluation of efficacy and safety of GreenGene (Recombinant Factor VIII).
Study Overview
Study Type
Interventional
Enrollment (Actual)
71
Phase
- Phase 3
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
12 years and older (Child, Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Hemophilia A patients at least 12 years of age
- At least 150 treatment exposure-days to previous FVIII products
- FVIII≤2% at screening or diagnosis (FVIII≤1% for PK study)
- CD4 Lympocyte cell count>400/㎕
- Patients willing to cooperate for the study
- Patient's or legal guardian's consent to participate in the study
Exclusion Criteria:
- FVIII inhibitor(neutralizing antibody to FVIII)≥0.6 Bethesda Units
- Coagulation disorders other than hemophilia A (e.g. Idiopathic Thrombocytopenic Purpura, von Willebrand Disease)
- Platelet count≤100,000㎣
- Subjects with clinical evidence of symptomatic HIV disease regardless of HIV-seroposive/seronegative
- Subjects with rFVIII antibody, mouse IgG antibody, or CHO antibody
- Creatinine levels more than 2 times of reference rage, GOT and GPT levels more than 3 times of reference range, diabetes mellitus or other metabolic disorder
- Subjects with diastolic blood pressure≥100mmHg not controlled with antihypertensive medications
- Anemia(hemoglobin<12g/dL)
- Subjects with severe or life-threatening bleeding just before entry into the trial
- Subjects with a history of treatment failure due to formation of inhibitor to FVIII
- Subjects with a history of severe hypersensitive reactions to FVIII concentrate
- Subjects requiring pre-medication for FVIII infusion(e.g. antihistamines, etc)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: test drug
GreenGene
|
Dose : 10 ~ 50IU/kg Administration method : intravenous infusion or bolus
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Physician's assessment of hemostatic effect for on-demand treatment
Time Frame: 12 months
|
Category: Exellent, Good, Moderate, None
|
12 months
|
Hemostatic effect for major bleeding
Time Frame: up to 1 year
|
Category: Exellent, Good, Moderate, None
|
up to 1 year
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
consumption amount of test drug
Time Frame: up to 12 month or 100 exposure days
|
up to 12 month or 100 exposure days
|
|
Subject's self assessment of treatment
Time Frame: 12 months
|
Category: Exellent, Good, Moderate, None
|
12 months
|
FVIII Recovery(%)
Time Frame: every 3 months
|
every 3 months
|
|
FVIII inhibitor incidence rate
Time Frame: every 3 months
|
every 3 months
|
|
The number of adverse events
Time Frame: up to 1 year
|
up to 1 year
|
|
Surgery study: prohylactic effects
Time Frame: up to 1 year
|
Category: Exellent, Good, Moderate, None
|
up to 1 year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
December 1, 2004
Primary Completion (Actual)
September 1, 2006
Study Completion (Actual)
September 1, 2006
Study Registration Dates
First Submitted
March 22, 2012
First Submitted That Met QC Criteria
March 29, 2012
First Posted (Estimate)
April 2, 2012
Study Record Updates
Last Update Posted (Estimate)
April 2, 2012
Last Update Submitted That Met QC Criteria
March 29, 2012
Last Verified
March 1, 2012
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- GC8AIII
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Hemophilia A
-
Christoph KönigsRoche Pharma AG; Chugai Pharma Germany GmbHRecruitingSevere Hemophilia A | Severe Hemophilia A With Inhibitor | Severe Hemophilia A Without InhibitorGermany
-
GWT-TUD GmbHHannover Medical School; Hoffmann-La RocheCompleted
-
Kathelijn FischerRadboud University Medical Center; University Medical Center Groningen; Maastricht... and other collaboratorsRecruitingAdolescent | Child | Hemophilia A With Inhibitor | Adult | Hemophilia A Without Inhibitor | Hemophilia A, SevereNetherlands
-
Hoffmann-La RocheActive, not recruitingSevere Hemophilia A | Moderate Hemophilia ABrazil, Germany, Italy, Spain, United States, Turkey, United Kingdom, Tunisia, Canada, Hungary, Morocco, Serbia
-
Catalyst BiosciencesCompletedHemophilia A | Hemophilia B | Hemophilia A With Inhibitor | Hemophilia B With Inhibitor | Hemophilia A Without Inhibitor | Hemophilia B Without InhibitorBulgaria, Russian Federation
-
JW PharmaceuticalRecruitingHemophilia A With Inhibitor | Hemophilia A Without InhibitorKorea, Republic of
-
PfizerCompletedFactor VIII Deficiency, Congenital | Hemophilia A, Congenital | Factor 8 Deficiency, Congenital | Autosomal Hemophilia A | Classic Hemophilia
-
BioMarin PharmaceuticalRecruitingHemophilia A With Inhibitor | Hemophilia A With Anti Factor VIIIUnited States, United Kingdom, Taiwan, Israel, Korea, Republic of, South Africa, Brazil, Italy, Germany
-
American Thrombosis and Hemostasis NetworkTakeda; CSL Behring; OctapharmaCompletedHemophilia A | Hemophilia B | Hemophilia | Hemophilia A With Inhibitor | Haemophilia | Hemophilia B With Inhibitor | Haemophilia A Without Inhibitor | Haemophilia B Without InhibitorUnited States
-
BayerCompletedHemophilia A; Hemophilia BIsrael
Clinical Trials on GreenGene
-
Green Cross CorporationAtlantic Research GroupUnknown
-
Green Cross CorporationAtlantic Research GroupUnknownHemophilia AUnited States, Canada, New Zealand, Poland, Russian Federation, Ukraine, United Kingdom