- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01628562
A Comparison of the Perioperative Hemodynamic Effects of Remifentanil and Esmolol in Intracranial Surgery
A Comparison of the Perioperative Hemodynamic Effects of Remifentanil and Esmolol: a Double Blind Randomized Controlled Study
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
During neurosurgical procedures intubation, insertion of the head pins, extubation and the early postoperative period are the time lines in which cerebral autoregulation can be impaired by changes in heart rate and blood pressure. Several anesthetic regimens have been implied to overcome this problem. Remifentanil is used in neurosurgery since it allows early recovery and neurologic evaluation. Esmolol on the other hand is also very short acting, effective to blunt cardiovascular responses during surgery and has no significant effect on intracranial pressure and cerebral blood flow. In addition esmolol is addressed to reduce perioperative ischemia during noncardiac surgery.
It was hypothesized that the use of esmolol as an alternative to remifentanil with sevoflurane inhalation anesthesia during intracranial surgery, could provide better hemodynamic conditions and cause lesser side effects in the perioperative period. It was the main objective of this study to compare the effect of esmolol and remifentanil on the incidence of tachycardia and hypertension and the intraoperative fentanyl consumption. The comparison of postoperative troponine I and creatine phosphokinase levels and EKG changes were the secondary objectives.
Study Type
Enrollment (Actual)
Phase
- Phase 4
Contacts and Locations
Study Locations
-
-
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Ankara, Turkey, 06610
- Diskapi Yildirim Beyazit Teaching and Research Hospital
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Intracranial surgery
Exclusion Criteria:
- heart rate ≤ 50,
- atrioventricular block,
- sick sinus syndrome,
- heart failure,
- history of asthma,
- hypertension,
- impaired renal or hepatic function,
- patients receiving beta blockers or calcium channel blockers,
- emergency surgery.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Triple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: GroupE/Esmolol infusion
Heart rate control, Beta blocker
|
Esmolol 50 mcg/kg/min
Other Names:
|
Experimental: GroupR/Remifentanil infusion
Heart rate control, opioid
|
Remifentanil 0.5 mcg/kg/min
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
It is the main objective of this study to compare the effect of esmolol and remifentanil on the incidence of tachycardia and hypertension
Time Frame: during intubation, head pin insertion, extubation, early postoperative period
|
during intubation, head pin insertion, extubation, early postoperative period
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
the intraoperative fentanyl consumption
Time Frame: during intubation, head pin insertion, extubation, early postoperative period
|
during intubation, head pin insertion, extubation, early postoperative period
|
Collaborators and Investigators
Investigators
- Principal Investigator: Dilek Yazicioglu, MD
Publications and helpful links
General Publications
- Heinke W, Zysset S, Hund-Georgiadis M, Olthoff D, von Cramon DY. The effect of esmolol on cerebral blood flow, cerebral vasoreactivity, and cognitive performance: a functional magnetic resonance imaging study. Anesthesiology. 2005 Jan;102(1):41-50. doi: 10.1097/00000542-200501000-00010.
- Landoni G, Turi S, Biondi-Zoccai G, Bignami E, Testa V, Belloni I, Cornero G, Zangrillo A. Esmolol reduces perioperative ischemia in noncardiac surgery: a meta-analysis of randomized controlled studies. J Cardiothorac Vasc Anesth. 2010 Apr;24(2):219-29. doi: 10.1053/j.jvca.2009.07.008. Epub 2009 Oct 2.
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Heart Diseases
- Cardiovascular Diseases
- Vascular Diseases
- Arrhythmias, Cardiac
- Cardiac Conduction System Disease
- Myocardial Ischemia
- Ischemia
- Tachycardia
- Physiological Effects of Drugs
- Adrenergic beta-Antagonists
- Adrenergic Antagonists
- Adrenergic Agents
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Central Nervous System Depressants
- Peripheral Nervous System Agents
- Analgesics
- Sensory System Agents
- Analgesics, Opioid
- Narcotics
- Adrenergic beta-1 Receptor Antagonists
- Remifentanil
- Esmolol
Other Study ID Numbers
- Dilek Esmolol
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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