- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01675310
Medical Nutrition Therapy Plus Transgestational Metformin For Preventing Gestational Diabetes In High Risk Mexican Women
EFFECTIVITY OF MEDICAL NUTRITION THERAPY PLUS TRANSGESTATIONAL METFORMIN FOR PREVENTING THE INCIDENCE OF GESTATIONAL DIABETES MELLITUS IN HIGH RISK MEXICAN WOMEN.
Gestational diabetes mellitus is one of the most frequent complications of pregnancy, that affect between 1 to 14% of population around the world.
There is a few studies to prevent gestational diabetes mellitus in high risk women as Mexican population.
Metformin has been used during pregnancy in women with gestational diabetes and women with polycystic ovary syndrome, with acceptable security for mother and fetus.
Metformin decrease the insulin resistance and weight gain, we believe that metformin may be decrease the risk of gestational diabetes mellitus in high risk women.
Study Overview
Status
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Phase 4
Contacts and Locations
Study Locations
-
-
-
Mexico, Mexico, 11000
- National Institute of Perinatology
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
Mexican women with pregnancy < 16 weeks of gestation, normal oral glucose tolerance 75g-2h test and 3 or more criteria:
- Body mass index > 27 kg/m2
- Maternal age >25
- History of infertility with polycystic ovary syndrome
- History of macrosomic newborn (Weight >4000g)
- History of diabetes mellitus in first or second degree.
- History of gestational diabetes in previous pregnancy
Exclusion Criteria:
- Any form of pregestational diabetes
- Fasting glucose > 126 mg/dL at first prenatal visit.
- seric creatinine > 1.5 mg/dL
- Hyperthyroidism
- Heart disease
- Hepatic disease
- Renal diseases
- Epilepsy
- Lupus
- Chronic hypertension.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: medical nutrition therapy + metformin
medical nutrition therapy plus trans-gestational metformin (850mg 2 times day)
|
|
Active Comparator: medical nutrition therapy
medical nutrition therapy without trans-gestational metformin
|
medical nutrition therapy
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Gestational diabetes mellitus
Time Frame: 27-28 weeks of gestation
|
oral glucose tolerance test
|
27-28 weeks of gestation
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
insulin resistance
Time Frame: At birth
|
measure of insulin resistance by HOMA-IR, sample of umbilical cord
|
At birth
|
Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Enrique Reyes-Muñoz, PhD, National Institute of Perinatology, Mexico City
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Glucose Metabolism Disorders
- Metabolic Diseases
- Neoplasms
- Endocrine System Diseases
- Ovarian Cysts
- Cysts
- Ovarian Diseases
- Adnexal Diseases
- Gonadal Disorders
- Diabetes Mellitus
- Pregnancy Complications
- Polycystic Ovary Syndrome
- Diabetes, Gestational
- Hypoglycemic Agents
- Physiological Effects of Drugs
- Metformin
Other Study ID Numbers
- Conacyt 151819
- INPer (Mexico) (Registry Identifier: 21225042101)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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