Medical Nutrition Therapy Plus Transgestational Metformin For Preventing Gestational Diabetes In High Risk Mexican Women

Inclusion Criteria:

• Mexican women with pregnancy < 16 weeks of gestation, normal oral glucose tolerance 75g-2h test and 3 or more criteria:

  1. Body mass index > 27 kg/m2
  2. Maternal age >25
  3. History of infertility with polycystic ovary syndrome
  4. History of macrosomic newborn (Weight >4000g)
  5. History of diabetes mellitus in first or second degree.
  6. History of gestational diabetes in previous pregnancy

Exclusion Criteria:

• Any form of pregestational diabetes
• Fasting glucose > 126 mg/dL at first prenatal visit.
• seric creatinine > 1.5 mg/dL
• Hyperthyroidism
• Heart disease
• Hepatic disease
• Renal diseases
• Epilepsy
• Lupus
• Chronic hypertension.