Study of the Acute Effects of Triheptanoin in Heart Failure (ACETO-TCA)

Assessment of the Clinical Effects of Triheptanoin Oil to Target Cardiac Anaplerosis in Congestive Heart Failure- Acute Study

Patients with dilated cardiomyopathy who present for indwelling right heart catheterization will be enrolled and randomized to either control or triheptanoin oil for five days. Hemodynamics will be assess serially.

Study Overview

• Status: Withdrawn
• Conditions: Congestive Heart Failure; Non-ischemic Cardiomyopathy
• Intervention / Treatment: Drug: Triheptanoin oil

Detailed Description

Consecutive patients with DCM presenting for a right heart catheterization will be enrolled. All patients will be presenting electively for hemodynamic assessment and will have their PA catheter left in place after their catheterization as part of their usual care. Post-procedure, patients will be monitored in the coronary care unit, which is routine for patients with these catheters. Patients will be approached for potential enrollment in the study protocol. The goal enrollment for this phase of the protocol is 24 patients (12 participants receiving triheptanoin and 10 receiving placebo).

Patients will randomly be assigned to receive either triheptanoin oil or control treatment (sugar syrup) four times a day one hour before meals and at night for five days. All patients will be given a low fat, low simple sugar diet to avoid potential substrate competition from high serum levels of fats and glucose for the duration of the study procedure. Participants will be blinded to their treatment assignment.

Treatment arm: The standard dose of triheptanoin oil for adults is 1-2gm/kg/24 hours. For purposes of this study, we will administer 0.25mg/kg four-times per day. The liquid study drug will be mixed into sugar-free, low fat yogurt, pudding or nutritional supplement shake, depending on patient preference.

Control arm: One tablespoon of sugar syrup will be mixed into sugar-free, low fat yogurt, pudding or nutritional supplement shake four-times per day before meals.

Thermodilution cardiac index and PCWP will be measured from the indwelling PA catheter at baseline and hourly for the first six hours. During this time, initiation or upward titration of vasodilator and inotropic mediations will be discouraged although the medications will be continued in patients previously on these medications. Patients requiring such vasoactive medications on an urgent basis will have been excluded from study participation (see below). After the first six hours, measurements will be recorded once a day, 90 minutes following ingestion of study medication for the four days of treatment, as well as for the following day off study medication (in order to assess off-treatment hemodynamics). Number and dose of intravenous vasoactive medications will be recorded daily.

The main outcome of interest is the change in cardiac index over the first 6 hours of the study period (before initiation of any other vasoactive medications). Pre-and post-cardiac index will be compared with a paired t-test. With 10 patients per study group, we have 80% power to detect a clinically significant 20% difference (0.4L/min/m2) in cardiac index between treatment assignments. Assuming the need for a non-parametric analysis a "standard" 20% increase in sample size will need sought.

Additionally, the change in cardiac output and PCWP over the five day study period will be compared between group assignments (control vs. triheptanoin oil). Either Friedman's test or ANOVA for repeated measures (depending on satisfaction of the normality assumption) will be employed to detect serial changes between each treatment. Between-group differences at each time-point will be assessed by a two-sample t-test or the Wilcoxon signed rank test. We will also measure off-treatment effects by comparing day 4 (final treatment day) cardiac output and PCWP with day 6 (one day off treatment).

Five (5) cc of blood will be collected into EDTA tubes from the PA catheter at baseline and hourly for the first six hours of the study. An additional 5cc of blood will be obtained on day 4 and day 5. Serum will be isolated and stored at -80C until completion of the study. At that time, the samples will be assayed for metabolic profiles, to include acylcarnitine and fatty acid metabolites. Prior work has demonstrated significant increases in serum odd-chain fatty acids, acyl-carnitines and ketones following ingestion.These data will inform on the pharmacodynamics of triheptanoin metabolism in the setting of HF. At baseline and on day 4 a urine sample will be obtained and assayed for species related to proprionate metabolism.

• Study Type: Interventional
• Phase: Phase 2; Phase 1

Contacts and Locations

Study Locations

• United States
  • Texas
    • Dallas, Texas, United States, 75390
      • University of Texas-Southwestern

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

Patients will be eligible for inclusion in this protocol if they satisfy the following criteria:

1. DCM with left ventricular ejection fraction (LVEF) ≤40%
2. New York Heart Association (NYHA) class III-IV symptoms
3. age ≥18
4. an indwelling PA catheter
5. and an anticipated clinical requirement for a PA catheter for at least five days.

Exclusion Criteria:

Patients will be ineligible for inclusion in this protocol if they have any of the following:

1. urgent (<6 hr) need for (or increase in) inotropic support (INTERMACS profile 1)
2. diabetes mellitus
3. known disorder of the respiratory chain or mitochondrial cardiomyopathy
4. significant hyperlipidemia with triglyceride value >300mg/dL
5. normal cardiac index (>2.5L/min/m2) on initial right heart catheterization
6. indwelling intra-aortic balloon pump
7. chronic liver disease
8. severe renal dysfunction (CKD stage IV-V) with creatinine clearance <30 mL/min/1.73m2
9. more than moderate valvular stenosis or regurgitation
10. pregnancy or breastfeeding
11. peripartum cardiomyopathy diagnosed within the past year
12. inability to provide informed consent

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: SINGLE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
ACTIVE_COMPARATOR: Triheptanoin oil; The standard dose of triheptanoin oil for adults is 1-2gm/kg/24 hours. For purposes of this study, we will administer 0.25mg/kg four-times per day. The liquid study drug will be mixed into sugar-free, low fat yogurt, pudding or nutritional supplement shake, depending on patient preference.	Drug: Triheptanoin oil
PLACEBO_COMPARATOR: Simple sugar; 0.25mg/kg of sugar syrup will be mixed into sugar-free, low fat yogurt, pudding or nutritional supplement shake four-times per day before meals.	Drug: Triheptanoin oil

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cardiac output/index	The main outcome of interest is the change in cardiac index over the first 6 hours of the study period (before initiation of any other vasoactive medications). Pre-and post-cardiac index will be compared with a paired t-test. With 10 patients per study group, we have 80% power to detect a clinically significant 20% difference (0.4L/min/m2) in cardiac index between treatment assignments. Assuming the need for a non-parametric analysis a "standard" 20% increase in sample size will need sought. This yields a final 12 patient per group (n=24 total) sample size	6 hours

Secondary Outcome Measures

Outcome Measure	Time Frame
Cardiac Output/index and pulmonary capillary wedge pressure	5 days

Collaborators and Investigators

• Sponsor: University of Texas Southwestern Medical Center
• Investigators: Principal Investigator: Aslan T Turer, MD, MHS, UT-Southwestern

Study record dates

Study Major Dates

• Study Start (ACTUAL): February 1, 2013
• Primary Completion (ACTUAL): February 1, 2014
• Study Completion (ACTUAL): February 1, 2014

Study Registration Dates

• First Submitted: February 6, 2013
• First Submitted That Met QC Criteria: February 8, 2013
• First Posted (ESTIMATE): February 11, 2013

Study Record Updates

• Last Update Posted (ACTUAL): December 14, 2018
• Last Update Submitted That Met QC Criteria: December 12, 2018
• Last Verified: December 1, 2018

More Information

Terms related to this study

• Keywords: Heart failure; Anaplerosis; Medium-chain fatty acid
• Additional Relevant MeSH Terms: Heart Diseases; Cardiovascular Diseases; Heart Failure; Cardiomyopathies
• Other Study ID Numbers: UTSW 65827-1