The Prognostic Assessment of Extubation in Aged Patients With Multiple Organ Dysfunction Syndrome

Key Technology Research of the Comprehensive Treatment of Multiple Organ Dysfunction Syndrome

The multiple organ dysfunction syndrome (MODS) has remained the major factor contributing to prolongation of intensive and mortality. It is reported that the mortality rates have varied between 20% and 100%, depending on number, severity, duration, type and combination, and definition of dysfunction. In our study, the investigators explore some comprehensive treatment technology to improved outcomes of MODS patients.

Study Overview

• Status: Unknown
• Conditions: Multiple Organ Dysfunction Syndrome

• Study Type: Observational
• Enrollment (Anticipated): 1

Contacts and Locations

Study Locations

• China
  • Beijing
    • Beijing, Beijing, China, 100853
      • Recruiting
      • Chinese PLA General Hospital
      • Contact: Xie Lixin, doctor; Phone Number: +86 010 55499130; Email: xielx@263.net

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 60 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

All subjects were selected from among inpatients who were hospitalized between Jan 2009 and May 2013 in the Respiratory Intensive Care Unit(RICU),Surgical Intensive Care Unit(SICU) and Emergency Intensive Care Unit(EICU).

Description

Inclusion Criteria:

• age > 60 years old;
• presence of altered organ function in an acutely ill patient such that homeostasis cannot be maintained without intervention;
• have trachea intubation after admitting to intensive care unit within 24 hours.

Exclusion Criteria:

• end stage multiple organ failure.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
the prognostic assessment of aged patients with MODS	According to the outcomes of 28-day,all the enrolled patients were divided into survival group and death group, clinical datum of which were collected and analysed. And then these prognosis were evaluated with the current scoring systems [(Acute Physiology and Chronic Health EvaluationⅡ(APACHEⅡ, APACHE Ⅲ), Sample Acute Physiological score(SAPSⅡ), Multiple Organ Dysfunction score(MODS)], the predictive power of which were compared by receiver operating characteristic(ROC) curve. Finally, a binary logistic regression analysis was performed to evaluate the concerning prognostic factors of MODSE.	28 days

Collaborators and Investigators

• Sponsor: Chinese PLA General Hospital

Publications and helpful links

General Publications

• Xiao K, Su L, Han B, Guo C, Feng L, Jiang Z, Wang H, Lin Y, Jia Y, She D, Xie L. Prognosis and weaning of elderly multiple organ dysfunction syndrome patients with invasive mechanical ventilation. Chin Med J (Engl). 2014;127(1):11-7.

Study record dates

Study Major Dates

• Study Start: January 1, 2009
• Primary Completion (ANTICIPATED): December 1, 2013
• Study Completion (ANTICIPATED): December 1, 2013

Study Registration Dates

• First Submitted: February 27, 2013
• First Submitted That Met QC Criteria: March 1, 2013
• First Posted (ESTIMATE): March 4, 2013

Study Record Updates

• Last Update Posted (ESTIMATE): March 4, 2013
• Last Update Submitted That Met QC Criteria: March 1, 2013
• Last Verified: February 1, 2013

More Information

Terms related to this study

• Keywords: Prognosis; Aged; Extubation; invasive mechanical ventilation; Multiple organ failure; MODS
• Additional Relevant MeSH Terms: Pathologic Processes; Disease; Shock; Syndrome; Multiple Organ Failure
• Other Study ID Numbers: 2013670808