Macular Hemorrhage in Myopic Eyes

Visual impairment in high myopic eyes is mainly due to the different types of myopic maculopathies, such as diffuse or patchy atrophy, lacquer cracks and choroidal neovascularization. Macular hemorrhage was one of those complications. Despite choroidal neovascularization, simple hemorrhage from rupture of Bruch's membrane and choroidal microcirculation is also the cause of hemorrhage. The prognosis of those eyes with simple hemorrhage is generally good. However, some patients had persistently poor vision after the absorption of the hemorrhage. In the literature, the visual prognosis in those patients was reported to be associated with the microstructure change under the optical coherent tomography (OCT) or the presentation of the autofluorescence. The investigators will collect the patients with high myopia and presenting with macular hemorrhage. High resolution OCT and autofluorescence imaging will be used to analyze the change of the microstructure of retina and its correlation with the visual prognosis.

Study Overview

• Status: Unknown
• Conditions: High Myopia; Macula Lutea Hemorrhage

• Study Type: Observational
• Enrollment (Anticipated): 30

Contacts and Locations

Study Locations

• Taiwan
  • Taipei, Taiwan, 100
    • Recruiting
    • Department of Ophthalmology, National Taiwan University Hospital
    • Contact: Tzyy-Chang Ho, MD; Phone Number: 62579 886-2-23123456; Email: hotc@ntuh.gov.tw
    • Contact: Ting-Yu Wu, MD; Phone Number: 62580 886-2-23123456; Email: b89401001@ntu.edu.tw

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 80 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

1. Myopia more than -6D
2. Macular hemorrhage inside arcade
3. Patients who are willing to visit our clinic and receive examination regularly for at least 1 year

Description

Inclusion Criteria:

• Myopia more than -6D
• Macular hemorrhage inside arcade
• Patients who are willing to visit our clinic and receive examination regularly for at least 1 year

Exclusion Criteria:

• Patients who cannot cooperate.
• Macular hemorrhage unrelated to myopia

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
visual acuity	visual acuity during follow up and its correlation to other factors	1 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Optical coherence tomography	Change of microstructure of the retina and choroid on OCT during follow up	1 year

Collaborators and Investigators

• Sponsor: National Taiwan University Hospital
• Investigators: Principal Investigator: Tzyy-Chang Ho, MD, National Taiwan University Hospital

Study record dates

Study Major Dates

• Study Start: August 1, 2013
• Primary Completion (ANTICIPATED): May 1, 2015
• Study Completion (ANTICIPATED): May 1, 2015

Study Registration Dates

• First Submitted: September 12, 2013
• First Submitted That Met QC Criteria: September 16, 2013
• First Posted (ESTIMATE): September 17, 2013

Study Record Updates

• Last Update Posted (ESTIMATE): April 15, 2014
• Last Update Submitted That Met QC Criteria: April 13, 2014
• Last Verified: April 1, 2014

More Information

Terms related to this study

• Keywords: Optical Coherence Tomography; High Myopia; Macula Lutea Hemorrhage
• Additional Relevant MeSH Terms: Pathologic Processes; Eye Diseases; Refractive Errors; Hemorrhage; Myopia
• Other Study ID Numbers: 201303121RINC