The Influence of High Impact Exercise on Musculoskeletal Health in Older Men (Hiphop)

Osteoporotic fractures are an extremely common and serious public health issue which contribute substantially to pain, impaired mobility and morbidity in the elderly. Declines in bone strength combined with an increase risk of falls (associated with decline in muscular function with age) are the main determinants of fracture risk. Exercise that is novel and involves impact loading has the potential to improve bone strength and neuromuscular function (strength, power and balance). It is thus imperative to evaluate potential benefits of exercise in older people. The musculoskeletal responses to exercise may also be influenced by vitamin D status. It is the purpose of this study to consider the influence of a one year unilateral (one limb) high impact exercise programme on musculoskeletal health, specifically bone structure, muscle strength and power in older caucasian men. It is also the purpose of this study to determine whether this differs according to vitamin D status. The findings will reveal whether exercise can improve bone health and/or neuromuscular function, and whether improvements are dependent upon vitamin D status.

Study Overview

• Status: Completed
• Conditions: Bone Strength; Neuromuscular Function
• Intervention / Treatment: Behavioral: Exercise

• Study Type: Interventional
• Enrollment (Actual): 50
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United Kingdom
  • Leicestershire
    • Loughborough, Leicestershire, United Kingdom, LE11 3TU
      • Loughborough University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years to 80 years (OLDER_ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Healthy community dwelling men of white european origin

Exclusion Criteria:

• BMI >30 kg/m2
• History of strength training or recently ( previous 12 months) doing moderate physical activity (weight bearing, high impact)
• Recent ( previous 12 months) or current medical or surgical problems likely to affect bone metabolism or provide contraindications to high impact exercise, balance or neuromuscular function
• Any previous or existing lower back or limb problems that could be exacerbated by undertaking high impact exercise
• Any history of diagnosed or symptomatic diseases likely to influence strength, power, bone or habitual activity (including osteomalacia or impaired liver/renal function and locomotor disease, hypertension) that influences bone or muscle or precludes exercise

Study Plan

How is the study designed?

Design Details

• Primary Purpose: BASIC_SCIENCE
• Allocation: RANDOMIZED
• Interventional Model: SINGLE_GROUP
• Masking: SINGLE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Exercise leg	Behavioral: Exercise; multidirectional unilateral hopping exercise
NO_INTERVENTION: Control leg

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Change in femoral neck bone mineral density	baseline, 12 months

Secondary Outcome Measures

Outcome Measure	Time Frame
Change in cortical bone mineral content	baseline, 12 months
Change in trabecular bone mineral content	baseline, 12 months
Change in ground reaction force during hopping	baseline, 6 months, 12 months
Change in electromyography of quadriceps during hopping	baseline, 6 months
Change in postural sway amplitude (mm)	baseline, 6 months
Change in leg press strength	baseline, 6 months
Change in maximal isometric knee extensor strength	baseline, 6 months
Change in tendon stiffness	baseline, 6 months

Other Outcome Measures

Outcome Measure	Time Frame
Serum 25 hydroxy vitamin D	baseline
Change in body fat content	baseline, 12 months
change in energy intake (MJ/d)	baseline, 12 months
change in calcium intake	baseline, 12 months

Collaborators and Investigators

• Sponsor: Loughborough University
• Collaborators: University Hospitals of Derby and Burton NHS Foundation Trust; University Hospitals Leicester NHS Trust, UK
• Investigators: Principal Investigator: Katherine Brooke-Wavell, PhD, Loughborough University; Principal Investigator: Winston Rennie, MBBS, University Hospitals Leicester NHS Trust; Principal Investigator: Jonathan Folland, PhD, Loughborough University; Principal Investigator: Greg Summers, MD, Derby University Hospitals Trust

Publications and helpful links

General Publications

• Allison SJ, Folland JP, Rennie WJ, Summers GD, Brooke-Wavell K. High impact exercise increased femoral neck bone mineral density in older men: a randomised unilateral intervention. Bone. 2013 Apr;53(2):321-8. doi: 10.1016/j.bone.2012.12.045. Epub 2013 Jan 3.

Study record dates

Study Major Dates

• Study Start: January 1, 2010
• Primary Completion (ACTUAL): January 1, 2012
• Study Completion (ACTUAL): January 1, 2012

Study Registration Dates

• First Submitted: November 27, 2013
• First Submitted That Met QC Criteria: December 5, 2013
• First Posted (ESTIMATE): December 10, 2013

Study Record Updates

• Last Update Posted (ESTIMATE): December 10, 2013
• Last Update Submitted That Met QC Criteria: December 5, 2013
• Last Verified: December 1, 2013

More Information

Terms related to this study

• Other Study ID Numbers: R10-P1