Sevoflurane Versus Desflurane for Catheter-related Bladder Discomfort

September 30, 2014 updated by: Seoul National University Hospital

Comparison of the Effects of Sevoflurane and Desflurane on Prevention of Catheter-related Bladder Discomfort

We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The mechanism of catheter-related bladder discomfort is thought to be related to the muscarinic receptor. The volatile anesthetics such as sevoflurane and desflurane are known to block the muscarinic receptor in different ways.

We want to evaluate the efficacy of the sevoflurane and desflurane for the prevention of catheter-related bladder discomfort.

Study Type

Interventional

Enrollment (Actual)

108

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 80 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Patients scheduled for transurethral bladder excision under general anesthesia
  • ASA I-III

Exclusion Criteria:

  • Bladder outflow obstruction
  • Overactive bladder
  • End-stage renal disease
  • Neurogenic bladder
  • Heart failure
  • Arrhythmia
  • Morbid obesity
  • Use of chronic analgesic medication
  • Hepatic disease
  • Pulmonary disease
  • Psychiatric disease

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: PREVENTION
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: TRIPLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: Sevoflurane
Sevoflurane will be administered as the maintenance agent of general anesthesia.
Drug: Sevoflurane
Sevoflurane will be used.
ACTIVE_COMPARATOR: Desflurane
Desflurane will be administered as the maintenance agent of general anesthesia.
Drug: Desflurane
Desflurane will be used

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Catheter-related bladder discomfort
Time Frame: 24 hour postoperatively
Catheter-related bladder discomfort will be measured for 24 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).
24 hour postoperatively

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Catheter-related bladder discomfort
Time Frame: 0, 1, 6 and 24 hour postoperatively
Catheter-related bladder discomfort will be measured at 0, 1, 6 and 24 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).
0, 1, 6 and 24 hour postoperatively
Nausea
Time Frame: 0, 1, 6 and 24 hour postoperatively
The degree of nausea will be assessed as none, mild, moderate and severe at 0, 1, 6 and 24 hour postoperatively.
0, 1, 6 and 24 hour postoperatively
Vomiting
Time Frame: 0, 1, 6 and 24 hour postoperatively
The degree of vomiting will be assessed as none, mild, moderate and severe at 0, 1, 6 and 24 hour postoperatively.
0, 1, 6 and 24 hour postoperatively
Dry mouth
Time Frame: 0 houe after admission of operating room
Dry mouth after the admission of operating room will be assessed. (score:0-10)
0 houe after admission of operating room

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Seoul National University Hospital

Investigators

  • Study Chair: Hee-Pyoung Park, PhD, Seoul National University of Hospital

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2014

Primary Completion (ACTUAL)

July 1, 2014

Study Completion (ACTUAL)

July 1, 2014

Study Registration Dates

First Submitted

March 21, 2014

First Submitted That Met QC Criteria

March 21, 2014

First Posted (ESTIMATE)

March 26, 2014

Study Record Updates

Last Update Posted (ESTIMATE)

October 2, 2014

Last Update Submitted That Met QC Criteria

September 30, 2014

Last Verified

March 1, 2014

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CRBDSevoDes

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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