- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02191449
The Influence of Preoperative Warfarin Medication on Thromboelastography and Blood Transfusion
Influence of Warfarin on Thromboelastography and Transfusion
Study Overview
Status
Conditions
Detailed Description
This study was a retrospective evaluation of patients who have received cardiac surgery with Maze-operation from March 2008 to November 2013.
Patients who have atrial fibrillation undergoing cardiac surgery with Maze-operation were included.
The following exclusion criteria are applied:
- Patients who have taken medicine related to coagulation (such as antiplatelets like aspirin and clopidogrel) except warfarin or bridged heparin
- Patients whose laboratory values could not be confirmed by medical records review.
Patients were categorized by two groups.
- W group: patients on atrial fibrillation who have taken warfarin for p.o medication.
- C group: patients on atrial fibrillation who have not taken warfarin for p.o medication.
Using blood sample, authors examined as follows:
- Preoperative (maximum 5days before operation) and postoperative (30min after ICU admission) coagulation values with haematologic values: PT/aPTT, INR, Hb, Hct, platelet levels.
- ROTEM values at 30min after anaesthetic induction and 30min after ICU admission: Clotting time (CT), clot formation time (CFT), maximum clot firmness (MCF), maximum lysis (ML)
- Intraoperative (during operation) and postoperative (during admission, an expected average of 5 weeks) total transfusion amount: RBC, FFP, PC, cryoprecipitate.
- Post operative 24 hr bleeding amount in the chest tube drain bottle.
- The duration (maximum 2 weeks) of warfarin discontinuation. (in W group)
Statistical analysis was performed using unpaired t-test and chi-square test to compare patients demographic data and other parameters. To determine the relationship of INR and ROTEM parameters with bleeding amount and transfusion amount, multiple linear regression model that accounted for all confounder variables was used. For each factor in the multiple regression model, variables with a p value of less than 0.10 were kept in the final model. The data was analyzed using the program Statistical Package for the Social Sciences ver. 18.0 (SPSS Inc, Chicago, USA). A value of p < 0.05 was considered statistically significant.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Seoul, Korea, Republic of, 143-729
- Konkuk University Medical Center
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
1. Patients who have atrial fibrillation undergoing cardiac surgery with Maze-operation.
- W group : Patients who have had warfarin therapy before operation due to treat Atrial fibrillation
- C group : Patients who have not had warfarin therapy before operation
Exclusion Criteria:
- 1. Patients who have taken medicine related to coagulation (such as antiplatelets like aspirin and clopidogrel) except warfarin or bridged heparin.
- 2. Patients whose laboratory values could not be confirmed by medical records review.
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Retrospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Rotational Thromboelastography : Clotting time (CT)
Time Frame: 30min after anesthetic induction and 15 mins after CPB weaning status
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30min after anesthetic induction and 15 mins after CPB weaning status
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Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Rotational Thromboelastography : clot formation time (CFT)
Time Frame: 30min after anesthetic induction and 15 mins after CPB weaning status
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30min after anesthetic induction and 15 mins after CPB weaning status
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Other Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Rotational Thromboelastography : maximum clot firmness (MCF)
Time Frame: 30min after anesthetic induction and 15 mins after CPB weaning status
|
30min after anesthetic induction and 15 mins after CPB weaning status
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Rotational Thromboelastography : maximum lysis (ML) level Rotational Thromboelastography : maximum lysis (ML) level
Time Frame: 30min after anesthetic induction and 15 mins after CPB weaning status
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30min after anesthetic induction and 15 mins after CPB weaning status
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amount of Blood transfusion
Time Frame: intraoperative (during operation) and postoperative (during admission, an expected average of 5 weeks)
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intraoperative (during operation) and postoperative (during admission, an expected average of 5 weeks)
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Coagulation values : preprothrombin time (PT)
Time Frame: preoperative (maximum 5days before operation) and postoperative (30min after ICU admission)
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preoperative (maximum 5days before operation) and postoperative (30min after ICU admission)
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Coagulation values : activated partial thromboplastin time (aPTT)
Time Frame: preoperative (maximum 5days before operation) and postoperative (30min after ICU admission)
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preoperative (maximum 5days before operation) and postoperative (30min after ICU admission)
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Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- KUH1160068
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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