Research of the Application of Triple Antibiotic Paste in Primary Teeth With Pericpical Periodontitis

July 21, 2014 updated by: Lin Jiacheng

Randomized Controlled Research of the Application of Triple Antibiotic Paste in Primary Teeth With

The triple antibiotic paste is widely used in young permanent teeth and permanent teeth root canal therapy with excellent antiantimicrobial effect.We hypothesize that its application in the treatment of periapical periodontitis of deciduous teeth is superior to other drugs currently in use as creosote.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

We design to collect a group of patients presenting primary teeth with periapical periodontitis in certain criterion. We will divide the patients into two groups randomly.One group will get treated with triple antibiotic paste while the other with creosote.We want to evaluate the short-term and long-term effects of the two groups to get a conclusion of the clinical value of triple antibiotic paste.

Study Type

Interventional

Enrollment (Anticipated)

100

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Guangdong
      • Guangzhou, Guangdong, China, 510055
        • Jicheng Lin

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

3 years to 8 years (Child)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • clinical diagnosis of periapical periodontitis
  • must be primary teeth
  • must be 3~8 years old
  • the permanent tooth germ is complete and didnot be involved

Exclusion Criteria:

  • blood disease
  • residual root that is advised to extract
  • serious periodontitis
  • allergy to the triple antibiotic paste

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: creosote
Creosote ，once，three weeks Triple Antibiotic Paste ，none
Drug: creosote
Pulp removal,Root canal irrigation and disinfection
Other Names:
  • oily liquid obtained by distillation of wood tar
Experimental: Triple Antibiotic Paste
Triple Antibiotic Paste,once,three weeks creosote,none
Drug: Metronidazole-Ciprofloxacin gatifloxacin-Clindamycin paste
Pulp removal,Root canal irrigation and disinfection,

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Evidence of lesion healing confirmed by cone beam computed tomography and X-rays
Time Frame: 1 year
1 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Lin Jiacheng

Investigators

  • Study Chair: Jiacheng Lin, Guanghua hospital of stomotology,Sun Yat-sen University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

June 1, 2013

Primary Completion (Anticipated)

December 1, 2014

Study Completion (Anticipated)

June 1, 2015

Study Registration Dates

First Submitted

July 17, 2014

First Submitted That Met QC Criteria

July 21, 2014

First Posted (Estimate)

July 22, 2014

Study Record Updates

Last Update Posted (Estimate)

July 22, 2014

Last Update Submitted That Met QC Criteria

July 21, 2014

Last Verified

July 1, 2014

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Tri-antibiotic-2014

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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