Does Meal Timing Affect Energy Expenditure (GRAZING)

March 15, 2018 updated by: Courtney Peterson, Pennington Biomedical Research Center
The purpose of this study is to find out if meal timing affects calories burned and blood sugar levels.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

10 overweight adult men and women will eat according to two different eating schedules: grazing and time-restricting feeding ("early eating"). While on each eating schedule, metabolism (calories burned) will be measured during a 24-hour stay in a respiratory chamber. Glucose levels-as well as key diurnal rhythms such in heart rate-will also be measured continuously. This study requires two 1-week periods of participation.

Study Type

Interventional

Enrollment (Actual)

11

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Louisiana
      • Baton Rouge, Louisiana, United States, 70808
        • Pennington Biomedical Research Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 45 years (ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Are 20-45 years of age
  • Have a weight between 150 and 220 lbs
  • Have a body mass index between 25 and 35 kg/m2 inclusive (a number calculated from your height and weight)
  • If you are a female, have a regular menstrual cycle that is between 25 and 35 days long
  • If you are female, had your period within the last 35 days
  • Regularly go to sleep between 9:30 pm and 12:00 am
  • Regularly eat dinner 9 or more hours after eating breakfast
  • Are willing to have about 2/3 cup of your blood stored for future research related to this study

Exclusion Criteria:

  • Have diabetes or are on anti-diabetes medication
  • Suffer from significant cardiovascular, renal (kidney), cardiac (heart), liver, lung or nervous system disease
  • Have stomach or intestinal problems
  • Regularly use medications such as steroids, beta blockers, adrenergic-stimulating agents, and laxatives
  • Take any medications or supplements known to affect sleep, circadian rhythms, or metabolism (with the exception that certain forms of birth control are allowed)
  • Have abnormal lab work that is clinically significant in the opinion of the study physician
  • Are pregnant or lactating
  • Take the Depo Provera shot, or use an Interuterine Device (IUD) or hormone patch for birth control
  • If you are on hormonal birth control, have been on a stable dose for less than 3 months
  • Have smoked or used nicotine/tobacco products within the last 3 months
  • Regularly do competitive sport training
  • Perform overnight shift work an average of one or more times per week
  • Have an irregular sleep schedule
  • Have an irregular eating schedule
  • Regularly drink 3 or more drinks of alcohol per day
  • Are not able or are unwilling to eat only the food and drink served to you by Pennington Biomedical, while in the study
  • Are not able or are unwilling to refrain from strenuous exercise while participating in the study
  • Are not able to spend 2 separate full days (for about 25 hours each) at Pennington Biomedical
  • Are not able to maintain a consistent sleep schedule while participating in the study
  • Are not able to maintain a consistent eating schedule while participating in the study
  • Are not able to stop drinking coffee and other caffeine-containing drinks on the day of and day prior to testing

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: PREVENTION
  • Allocation: RANDOMIZED
  • Interventional Model: CROSSOVER
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
PLACEBO_COMPARATOR: Grazing
Participants will eat meals spread over the course of the day ("grazing").
Behavioral: Grazing
EXPERIMENTAL: Time-restricted feeding (early eating)
Participants will eat meals only in the early part of the day (early lunch and very early dinner).
Behavioral: Time-restricted feeding (early eating)

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Energy expenditure (calories burned)
Time Frame: 2 days
2 days

Secondary Outcome Measures

Outcome Measure
Time Frame
Blood sugar levels
Time Frame: 2 days
2 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Pennington Biomedical Research Center

Collaborators

The Obesity Society

Investigators

  • Principal Investigator: Courtney M Peterson, PhD, MSc, Pennington Biomedical Research Center

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

October 1, 2014

Primary Completion (ACTUAL)

November 1, 2017

Study Completion (ACTUAL)

November 1, 2017

Study Registration Dates

First Submitted

September 19, 2014

First Submitted That Met QC Criteria

September 22, 2014

First Posted (ESTIMATE)

September 23, 2014

Study Record Updates

Last Update Posted (ACTUAL)

March 16, 2018

Last Update Submitted That Met QC Criteria

March 15, 2018

Last Verified

March 1, 2018

More Information

Terms related to this study

Other Study ID Numbers

  • PBRC 2014-038

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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