Recording High Frequency Oscillations in Patients With Tumors and Epilepsy (HFO)

Recording High Frequency Oscillations in Patients With Tumors and Epilepsy.

The investigators want to characterize high-frequency oscillations (HFOs) in intracranial recordings, which may occur as markers of epileptogenic tissue and also under physiological stimulation.

The investigators want to show that recording of high-frequency oscillations (HFOs) is feasible in our project population both intraoperatively and during presurgical physiological conditions.

Study Overview

• Status: Enrolling by invitation
• Conditions: Epilepsy; Tumor
• Intervention / Treatment: Behavioral: cognitive testing

• Study Type: Observational
• Enrollment (Estimated): 120

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 99 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

1. Patients with epilepsy where a surgical resection is considered.
2. Patients where a tumor will be resected that has caused preoperative seizures.
3. Patients where a tumor will be resected that has not caused preoperative seizures.

Description

Inclusion Criteria:

• Patients intend to be treated at the Klinik für Neurochirurgie
• Patients fall into one of the patient groups: (1) Patients with symptomatic epilepsy with focal and/or secondary generalized seizures resistant to medication where a neurosurgical resection is considered as an intervention of epilepsy surgery. (2)Patients where a tumor is planned to be resected that has caused preoperative seizures. (3) Patients where a tumor is planned to be resected that has not caused preoperative seizures.
• Male and Female subjects 18 years to 99 years of age
• Written informed consent after participants' information

Exclusion Criteria:

• contraindications on ethical grounds
• known or suspected non-compliance, drug or alcohol abuse,
• enrolment into a clinical trial within last 4 weeks

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
epilepsy; epilepsy patients	Behavioral: cognitive testing; patients perform simple tasks like watching a video or memorizing items
tumor with epilepsy; tumor patients with epileptic seizures	Behavioral: cognitive testing; patients perform simple tasks like watching a video or memorizing items
tumor without epilepsy; tumor patients without epileptic seizures	Behavioral: cognitive testing; patients perform simple tasks like watching a video or memorizing items

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
HFO (high-frequency oscillations) occurrence	1 week

Collaborators and Investigators

• Sponsor: University of Zurich
• Investigators: Principal Investigator: Johannes Sarnthein, Prof Dr, Universitatsspital Zurich

Study record dates

Study Major Dates

• Study Start: June 1, 2014
• Primary Completion (Estimated): December 1, 2024
• Study Completion (Estimated): December 1, 2025

Study Registration Dates

• First Submitted: December 15, 2014
• First Submitted That Met QC Criteria: December 18, 2014
• First Posted (Estimated): December 19, 2014

Study Record Updates

• Last Update Posted (Actual): December 1, 2023
• Last Update Submitted That Met QC Criteria: November 30, 2023
• Last Verified: November 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Epilepsy
• Other Study ID Numbers: HFO