Genetic Analysis of Childhood Obesity (OSV)

March 2, 2020 updated by: Lille Catholic University
Identify news genetic causes of different type of obesity (syndromic, familial or isolated obesity) by highlighting new mutations or new implied genes

Study Overview

Status

Unknown

Conditions

Study Type

Observational

Enrollment (Anticipated)

300

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

      • Lille, France
        • Recruiting
        • Hopital Saint Vincent de Paul
        • Contact:
          • Louise Montagne

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

6 months to 18 years (Child, Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Three categories of obese children with their biological parents will be included (syndromic, familial, isolated obesity).

Description

Inclusion criteria:

  • BMI > curve of IOTF 30 (International Obesity Task Force)
  • Age: between 6 months old and 18 years old
  • Child presenting syndromic, isolated or familial obesity.

Exclusion Criteria:

  • Common obesity
  • Impossibility for blood sampling
  • Impossibility to receive information
  • Participation refusal of one of the parents
  • Refusal to sign the informed consent
  • Neither Healthcare coverage nor insurance

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Syndromic obesity
Identification of genetic causes of obesity
Familial obesity
Identification of genetic causes of obesity
A blood test will be performed to the child and his/her parents with the aim of identifying genetic causes of obesity. Different analysis will be as follows: caryotypes, Raindance, whole exome, in order to find potential mutations or new genes associated to this condition
Isolated obesity
Identification of genetic causes of obesity
A blood test will be performed to the child and his/her parents with the aim of identifying genetic causes of obesity. Different analysis will be as follows: caryotypes, Raindance, whole exome, in order to find potential mutations or new genes associated to this condition

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
To identify the number of mutations or genes involved in genetic causes of Child obesity
Time Frame: first day of enrollement
Children with obesity and their parents will be recruited to establish genetic causes of obesity. This will allow perform genetic analysis using new approaches for the identification of involved mutations or new candidate genes
first day of enrollement

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
To identify the number of mutations in the population
Time Frame: first day of enrollement
first day of enrollement
To identify the number of new mutations present in the children's DNA and absent from their parents' genomes
Time Frame: first day of enrollement
This approach will allow the identification of specific mutations that are present only in affected children but not in their parents
first day of enrollement
To determine number of phenotypes associated to the child obesity genotype
Time Frame: first day of enrollement
first day of enrollement

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Investigators

  • Principal Investigator: Louise Montagne, Groupement des Hôpitaux de l'Institut Catholique de Lille
  • Principal Investigator: Philippe Froguel, MD, PhD, UMR CNRS 8199, Institut Pasteur de Lille

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2015

Primary Completion (Anticipated)

December 1, 2020

Study Completion (Anticipated)

June 1, 2021

Study Registration Dates

First Submitted

December 15, 2014

First Submitted That Met QC Criteria

December 22, 2014

First Posted (Estimate)

December 29, 2014

Study Record Updates

Last Update Posted (Actual)

March 3, 2020

Last Update Submitted That Met QC Criteria

March 2, 2020

Last Verified

March 1, 2020

More Information

Terms related to this study

Other Study ID Numbers

  • RC-P0036

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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