Acute Effect of Exercise on Vascular Function

The study objectives are the following: 1) To examine the acute vascular responses to continuous low- and moderate-intensity exercise and interval training; and 2) To examine the influence of age and gender on these responses.

Study Overview

• Status: Completed
• Conditions: Aging
• Intervention / Treatment: Device: Treadmill; Other: Slow-paced walking; Other: Moderate-paced walking; Other: Interval Training

Detailed Description

The type, intensity and duration of exercise, fitness state, and timing of measurements have been reported to influence the acute vascular responses to exercise. However, little is known regarding the influence of interval training, aging and gender on these responses. The objectives of this study are: 1) to examine the acute vascular responses to continuous low- and moderate-intensity exercise and interval training; and 2) to examine the influence of age and gender on these responses. Subjects will perform the following 3 types of treadmill exercise in a random order: 1) slow-pace walking; 2) moderate-pace walking; and 3) interval training. Flow mediated dilation using high resolution ultrasonography and arterial stiffness using applanation tonometry will be measured before, immediately after and 1-hour after each acute bout of exercise.

• Study Type: Observational
• Enrollment (Actual): 69

Contacts and Locations

Study Locations

• United States
  • Florida
    • Gainesville, Florida, United States, 32611
      • Integrative Cardiovascular Physiology Laboratory

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 79 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

General population including men and women 18 to 79 years of age

Description

Inclusion Criteria:

• Men and women 18 to 79 years of age
• Women will be premenopausal or postmenopausal (either natural or surgical) defined as a cessation of menses for at least 2 years.
• Premenopausal women will be eumenorrheic.
• Able to give consent.

Exclusion Criteria:

• History of hepatic disease or infection with hepatitis B, C or HIV
• History of other relevant on-going or recurrent illness
• Recent (within 3 months) or recurrent hospitalizations
• Current intake of medications that may affect study results
• Use of tobacco products
• Premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy.
• Pregnancy (positive urine pregnancy test) or lactation
• Perimenopausal women

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Slow-paced walking; Subjects will complete 47 minutes of walking at slow pace.	Device: Treadmill; Other: Slow-paced walking; Subjects will complete 47 minutes of walking on a treadmill at a slow-pace.
Moderate-paced walking; Subjects will complete 47 minutes of walking at a moderate pace.	Device: Treadmill; Other: Moderate-paced walking; Subjects will complete 47 minutes of walking on a treadmill at a moderate pace.
Interval training; Subjects will complete 40 minutes of walking alternating between a moderate and fast pace.	Device: Treadmill; Other: Interval Training; Subjects will complete 40 minutes of walking on the treadmill alternating between a moderate and a fast pace.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in vascular endothelial function	Brachial artery endothelium-dependent flow-mediated dilation to reactive hyperemia will be measured using high resolution ultrasonography. Brachial artery diameter and blood velocity will be measured before and after occluding the forearm for 5 minutes by inflating a cuff to 250 mmHg.	Baseline, 15 minutes after exercise and 1 hour after exercise

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in arterial stiffness	Arterial stiffness (aortic pulse wave velocity and augmentation index) will be measured using applanation tonometry.	Baseline, 15 minutes after exercise and 1 hour after exercise

Collaborators and Investigators

• Sponsor: University of Florida

Study record dates

Study Major Dates

• Study Start: June 1, 2015
• Primary Completion (Actual): January 23, 2019
• Study Completion (Actual): January 23, 2019

Study Registration Dates

• First Submitted: March 31, 2015
• First Submitted That Met QC Criteria: April 2, 2015
• First Posted (Estimate): April 3, 2015

Study Record Updates

• Last Update Posted (Actual): January 25, 2019
• Last Update Submitted That Met QC Criteria: January 23, 2019
• Last Verified: January 1, 2019

More Information

Terms related to this study

• Other Study ID Numbers: IRB201401078