Preliminary Study to the Manufacturing of a Non-stick Membrane for Surgery Using Patient's Own Cells (MESO-PATCH) (MESO-PATCH)

March 12, 2026 updated by: Centre Oscar Lambret

Non-stick Patch of Mesothelial Cells in a Hydrogel Matrix : Exploratory Analysis Assessing the Morphotype and Mesothelial Phenotype After Culture From 2 Cells Sources of Human Origin.

The objective of this study, which will be realised in vitro on human samples, is to test 2 cell sources isolated from peritoneum for adult mesothelial cells (peritoneal samples) and from adipose tissue for the adipose stem cells (adipose tissue samples). The latter will be differentiated towards the mesothelial phenotype and morphotype. The 2 routes will be compared and the most satisfactory one will be chosen to make a non-stick patch.

Study Overview

Status

Terminated

Conditions

Intervention / Treatment

Detailed Description

  • Patient information and collection of a signed informed consent
  • Clinical data collection: surgery date, age, weight, height, medical and surgical history
  • Prospective collection of peritoneal and adipose biopsies of patients during their surgery at the Oscar Lambret Center (Dr L. BRESSON)
  • Transportation of the samples to the 1008 INSERM Unit.
  • Isolation of cells from the samples : mesothelial cells from the peritoneum and adipose stem cells from adipose tissue
  • Cell culture and expansion of mesothelial cells; and cell culture and differentiation of adipose stem cells
  • Identification by the morphotype and phenotype of mesothelial cells
  • Comparison of the results according to the cell source, peritoneum or adipocyte, to the purity of cells and to the efficacy of the expansion

Study Type

Interventional

Enrollment (Actual)

6

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Lille, France, 59020
        • Centre Oscar Lambret

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Aged more than 18 years old,
  • Planned surgery For peritoneal samples : abdominal surgery (laparotomy or coelioscopy) For adipose tissue samples : breast reconstructive surgery (lipomodelage)
  • Informed and signed consent

Exclusion Criteria:

  • Pregnant or breastfeeding woman
  • Patient under guardianship or tutorship
  • For peritoneal samples : previous abdomino-pelvic radiotherapy or abdominal surgery ; peritoneal carcinosis

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: N/A
  • Interventional Model: Single Group Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Biological samples collection

-Peritoneal samples : will be collected during abdominal surgery

A biopsy from 1 to 2 cm2 will be performed in healthy peritoneum

-Adipose tissue samples : will be collected during surgery for breast reconstruction
Procedure: Biological samples collection

-Peritoneal samples : will be collected during abdominal surgery

A biopsy from 1 to 2 cm2 will be performed in healthy peritoneum

- Adipose tissue samples : will be collected during surgery for breast reconstruction

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Morphotype/Phenotype expression
Time Frame: 1 year
Mesothelial morphotype and phenotype expression of the 2 types of cells after culture
1 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Oscar Lambret

Collaborators

Institut National de la Santé Et de la Recherche Médicale, France

Investigators

  • Principal Investigator: Lucie BRESSON, MD, Centre Oscar Lambret
  • Study Director: Feng Chai, MD, INSERM U1008

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

June 1, 2015

Primary Completion (Actual)

November 1, 2015

Study Completion (Actual)

November 1, 2016

Study Registration Dates

First Submitted

April 23, 2015

First Submitted That Met QC Criteria

May 5, 2015

First Posted (Estimated)

May 8, 2015

Study Record Updates

Last Update Posted (Actual)

March 16, 2026

Last Update Submitted That Met QC Criteria

March 12, 2026

Last Verified

March 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • MESO-PATCH-1408
  • 2014-A01866-41 (Other Identifier: ANSM)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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