- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02536872
A Study of the Effect of Antibiotics on the Microbiology of the Bladder in Patients With Overactive Bladder
An Observational Study of the Effect of Antibiotics on the Microbiology of the Bladder in Patients With Overactive Bladder
Study Overview
Status
Conditions
Detailed Description
This study is a consecutive cohort study. Subjects will be recruited from Urogynaecology clinics at Medway NHS Foundation Trust. Patients will be identified from previous records and also prospectively from new patients. They will be sent information regarding the trial before attending their first appointment.
Patients attending urogynaecology clinics will provide a fresh clean catch specimen of urine. A conventional hospital Mid stream speciemn of urine (MSU) will be sent. Urine will be dipsticked for nitrites and leucocyte esterase. The urine will then be spun and undergo microscopy using a special stain (looking for intracellular organisms in shed urothelial cells). The urothelial cells will be cleaned with antibiotics. The cells will then be lysed and their contents cultured. The contents will undergo Polymerase Chain Reaction (PCR) sequencing to identify bacteria. Sensitivity testing will be used to assess and deliver the appropriate antibiotic regime.
Women will be treated with a 6 week course of antibiotics as per their usual treatment. Broad spectrum antibiotics will be prescribed to all women based on the previous successful therapeutic regime as described by Vijaya. Six weeks after the end of antibiotic therapy patients will be reviewed and their urine retested.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
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Kent
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Gillingham, Kent, United Kingdom, ME17 3AN
- Medway Hospital
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- > age 18 years
- Negative urine dipstick (nitrites) and culture (x10 to the power 5 colony forming units) x105 cfu
- Idiopathic overactive bladder as per International Continence Society definition
Exclusion Criteria:
- Patients treated with antibiotics for any infection within the last 6 weeks.
- Patients with known multiple sclerosis, stroke, spinal injury, or other neurological disease
- Urinary tract infection diagnosed by nitrite positivity or positive urine culture (x105 cfu)
- Undiagnosed macroscopic or persistent microscopic haematuria needing investigation
- Previous or current cancer of the urogenital tract.
- Contraindication to multiple antibiotics
- No suitable oral antibiotic regime
- Patients unable to understand the study or complete the questionnaires.
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in bladder microbiology in patients treated with antibiotics.
Time Frame: 6 weeks
|
The number and type of different organisms will be quantified and compared to the pre treatment organisms
|
6 weeks
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change in the overactive bladder questionnaire (OAB-q) before and after treatment
Time Frame: 6 weeks
|
questionnaire
|
6 weeks
|
Change in Patient Perception of Bladder Condition (PPBC)
Time Frame: 6 weeks
|
questionnaire
|
6 weeks
|
To identify adherence to the treatment regime
Time Frame: 6 weeks
|
Patients will be asked to identify if they took all of the antibiotics; 75% of the time; 50 or 25%
|
6 weeks
|
To identify adverse effects of the treatment
Time Frame: 6 weeks
|
Patients will be asked report side effects of antibiotic treatment
|
6 weeks
|
Changes in symptoms using (change from baseline to assessment)
Time Frame: 6 weeks
|
Measured by the International consultation on Incontinence female lower urinary tract syptome questionnaire.
(ICI FLUTs)
|
6 weeks
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 19/06/2015
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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