Serum Lactate Trend in Liver Resection

Serum Lactate Trend in Liver Resection With Intermittent Pringle Maneuver: The "Square-Root" Shape

The study aimed to evaluate the correlation between the serum lactate concentration ed cumulative Pringle time after liver resection. In addition, the correlation between lactate clearance and clamping time was investigated.

Study Overview

• Status: Completed
• Conditions: Lactase Persistence

Detailed Description

During liver resection high serum lactate (sLac) concentration can be related to several clinical factors: impairment in lactate metabolism (i.e. extraction and utilization by the liver) or overproduction by splanchnic tissues; restrictive fluid regimen in order to limit the intraoperative back-flow bleeding; ischemia-reperfusion syndrome. However, the Pringle maneuver (temporary clamping of the hepatic hilum) seems having a sensible effect in inducing a significant increase in sLac levels during liver resection, particularly in the event of compromised liver function such as in cirrhosis.

Although the peak of sLac concentration may correlate with outcome, the lactate clearance (cLac) seems to be a better predictor. To date, this relationship has been mainly demonstrated in severe sepsis and shock septic. However, the effective correlation between the cumulative clamping time and cLac has not been clearly investigated. The correlation between cumulative hepatic ischemic time and sLac trend in the perioperative period after liver resection with intermittent PM was investigated.

• Study Type: Observational
• Enrollment (Actual): 133

Contacts and Locations

Study Locations

• Italy
  • Milan
    • Rozzano, Milan, Italy, 20089
      • Department of Hepatobiliary and General Surgery, Humanitas Research Hospital, University of Milan

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 34 years to 85 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

133 consecutive patients scheduled for liver resection for primary and secondary tumors

Description

Inclusion Criteria:

• Patients scheduled for liver resection for hepatic tumors

Exclusion Criteria:

• Patients who received blood transfusion or affected by chronic renal failure were excluded

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Serum lactate concentration trend after liver resection	within the first 30 days after surgery

Collaborators and Investigators

• Sponsor: University of Milan
• Investigators: Principal Investigator: Guido Guido, Guido, Humanitas Research Hospital, Humanitas University, via Manzoni 56, 20089 Milan

Study record dates

Study Major Dates

• Study Start: January 1, 2014
• Primary Completion (Actual): February 1, 2015
• Study Completion (Actual): February 1, 2015

Study Registration Dates

• First Submitted: September 23, 2015
• First Submitted That Met QC Criteria: September 29, 2015
• First Posted (Estimate): October 1, 2015

Study Record Updates

• Last Update Posted (Estimate): October 1, 2015
• Last Update Submitted That Met QC Criteria: September 29, 2015
• Last Verified: September 1, 2015

More Information

Terms related to this study

• Other Study ID Numbers: LacClearance