Effect of Plasma Rich in Growth Factors on Semen Quality

Effect of Plasma Rich in Growth Factors (PRGF) on Semen Quality

The hypothesis is growing semen samples with plasma rich in growth factors (PRGF), because it could improve sperm motility in patients subsidiary TRA, ultimately improving pregnancy rates.

Study Overview

• Status: Completed
• Conditions: Vascular Endothelial Growth Factor Overexpression
• Intervention / Treatment: Biological: PRGF in candidates for sperm donors

Detailed Description

Platelet growth factors are a group of proteins involved in cellular communication modifying biological responses. Obtaining plasma rich in growth factors is already widespread and simple protocol technique that is being used in various areas of medicine with superb results. Described many of the growth factors present in the PRGF are related to sperm parameters, especially motility The described effects have been studied in mammalian and each growth factor individually. PRGF contains a pool of growth factors and therefore be interesting to analyze their effect on various sperm parameters.

One of those parameters is very important for fertilization sperm motility, since the lack of it will prevent displacement by the cervix to meet the egg in the fallopian tube.

• Study Type: Observational
• Enrollment (Actual): 20

Contacts and Locations

Study Locations

• Spain
  • Vitoria, Spain
    • BTI
  • Vizcaya
    • Leioa, Vizcaya, Spain, 48940
      • IVI Bilbao
    • Leioa, Vizcaya, Spain, 48011
      • IVI Bilbao

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

• Sampling Method: Non-Probability Sample

Study Population

Prospective study of 58 candidates for sperm donors clinic IVI Bilbao.

Description

Inclusion Criteria:

• 18-35 years
• more than 5 million sperm per milliliter

Exclusion Criteria:

• Not having genetic and infectious diseases
• Do not suffer mental illness
• Have a family study determined that there is no risk of hereditary diseases
• There have fathered more than 6 children in the country

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Only
• Time Perspectives: Prospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
PRGF in candidates for sperm donors; Prospective study of 58 candidates for sperm donors clinic IVI Bilbao.	Biological: PRGF in candidates for sperm donors; PRGF application on seminal aliquots will be conducted at different concentrations assessing sperm motility.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Evaluate the percentage of motile sperm adding PRGF versus those samples that growth factors were not added	Within concerted donor visits in IVI Bilbao will be held: Removing Blood 9 mL of blood to obtain plasma rich in factors growth; Seminogram to analyze all semen parameters according to the criteria of the WHO (2010), paying particular attention to sperm motility.; Sperm vitality will be analyzed before and after treatment with PRGF. PRGF application on the seminal aliquots will be conducted at different concentrations assessing sperm motility.	6 months

Collaborators and Investigators

• Sponsor: IVI Bilbao
• Collaborators: bTI Vitoria
• Investigators: Study Director: Marcos Ferrando, IVI Bilbao

Study record dates

Study Major Dates

• Study Start (Actual): April 1, 2016
• Primary Completion (Actual): July 1, 2016
• Study Completion (Actual): December 1, 2017

Study Registration Dates

• First Submitted: March 4, 2016
• First Submitted That Met QC Criteria: March 9, 2016
• First Posted (Estimate): March 15, 2016

Study Record Updates

• Last Update Posted (Actual): August 1, 2022
• Last Update Submitted That Met QC Criteria: July 29, 2022
• Last Verified: July 1, 2022

More Information

Terms related to this study

• Other Study ID Numbers: 1411-BIO-081-MF

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: Yes
• IPD Plan Description: share data to BTI