Melatonin Supplementation and Performance (MSP)

Nocturnal Melatonin Ingestion Ameliorates Short Term Maximal Performances on the Following Day

The present study aimed to evaluate the possible effect of nocturnal melatonin ingestion upon short-term performances, on the following morning. Twelve soccer players from a Tunisian squad (22.9 ±1.3 years, 1.80±0.05 m, and 72.0±8.8 kg) were volunteered to perform three testing sessions, with one test session per day. During each session, MEL (5mg) , MEL (8mg) or placebo were ingested, in a randomized order, before nocturnal sleep. The next morning (08:00h), participants performed the following psycho-cognitive and physical tests: Hooper's index, reaction time, vigilance, handgrip strength , squat jump , modified agility test , Wingate anaerobic test (peak power , mean power and fatigue index ). Rating of perceived exertion was recorded immediately after the WanT, and blood lactate measures were taken after 3min of recovery. Blood glucose was measured before and 3 min after the Wingate test.

Study Overview

• Status: Terminated
• Conditions: Motor Activity
• Intervention / Treatment: Dietary supplement: Experimental: Melatonin; Dietary supplement: Placebo

• Study Type: Interventional
• Enrollment (Actual): 12
• Phase: Early Phase 1

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 23 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

The participants were recruited based on the following criteria: (i) paticipants must be trained at 4-6 days per week for an average of 2 h daily and (ii) they must have at least 8 years of training experience

Exclusion Criteria:

• Subjects were excluded from the study if they present one of the following criteria : heart failure, antioxidant supplementation within 3 months before the study, lower-limb injuries

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo	Dietary supplement: Placebo; In a double-blind randomized design, participants have taken placebo supplementation in one of the three experimental sessions
Experimental: Melatonin	Dietary supplement: Experimental: Melatonin; Our protocol was composed of three experimental sessions. During each testing session, participants were requested to attend the laboratory at 20:00h where they ingested a standardized light meal. Melatonin (5 mg or 8 mg) or placebo were ingested in capsule in the evening at 21:00h in a double-blind randomized design

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Hooper's index score	Hooper's index score was measured using a specific questionnaire	At 07:30 am in the following day of the supplementation
handgrip strength (in Kg)	handgrip strength was measured using a calibrated hand dynamometer.	At 07:30 am in the following day of the supplementation
Blood lactate (µmol/l)	Lactate level was measured using Lactate Pro instrument.	Blood lactate was measured only 3 minutes after physical testing in the following day of the supplementation
reaction time (in secondes)	Reaction time was measured using an electronic timing device.	At 07:30 am in the following day of the supplementation
vigilance score	Vigilance score was measured using a specific questionnaire	At 07:30 am in the following day of the supplementation
squat jump (in centimeters)	Squat jump was assessed using a infrared jump system	At 07:30 am in the following day of the supplementation
agility (in secondes)	Agility was assessed using an electronic timing system.	At 07:30 am in the following day of the supplementation
anaerobic capacity (In watts)	Anaerobic capacity was assessed using a calibrated friction-loaded cycle ergometer	At 07:30 am in the following day of the supplementation
glucose level (µmol/l)	Glucose level was assessed using a glucometer	At 07:30 am in the following day of the supplementation (rest condition) and 3 minutes after physical testing in each experimental session
Rating of perceived exertion score	Rating of perceived exertion score was measured using a specific questionnaire	Rating of perceived exertion score was measured 3 minutes after physical testing in the following day of the supplementation

Collaborators and Investigators

• Sponsor: kais

Study record dates

Study Major Dates

• Study Start: December 1, 2012
• Primary Completion (Actual): January 1, 2013
• Study Completion (Actual): January 1, 2013

Study Registration Dates

• First Submitted: August 2, 2016
• First Submitted That Met QC Criteria: August 18, 2016
• First Posted (Estimate): August 24, 2016

Study Record Updates

• Last Update Posted (Estimate): August 24, 2016
• Last Update Submitted That Met QC Criteria: August 18, 2016
• Last Verified: August 1, 2016

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Physiological Effects of Drugs; Molecular Mechanisms of Pharmacological Action; Central Nervous System Depressants; Protective Agents; Antioxidants; Melatonin
• Other Study ID Numbers: CNMSS1