- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02923674
Empowered With Movement to Prevent Obesity and Weight Regain (EMPOWER)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
North Carolina
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Winston-Salem, North Carolina, United States, 27157
- Wake Forest Baptist Health Sticht Center on Aging
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- 65-85 years
- BMI=30-45 kg/m2
- Weight stable-no loss or gain (±5%) in past 6 mo
- Sedentary
- No contraindication for safe and optimal participation in exercise training
- Approved for participation by Medical Director
- Willing to provide informed consent
- Agree to all study procedures and assessments
- Able to provide own transportation to study visits and intervention
Exclusion Criteria:
- Dependent on cane or walker
- Reported unintentional or intentional weight loss or gain of >5% in past 6 mo Participation in regular resistance training and/or > 20 mins/day of aerobic exercise in past 6 months
- Cognitive impairment (MoCA score <22)
- Low bone density (T-score < -2.3 on hip or spine scan)
- Severe arthritis, or other musculoskeletal disorder
- Joint replacement or other orthopedic surgery in past 6 mos
Joint replacement or other orthopedic surgery planned in next 2 years
- Uncontrolled resting hypertension (>160/90 mmHg);
- Current or recent past (within 1 year) severe symptomatic heart disease, uncontrolled angina, stroke, chronic respiratory disease other than asthma or COPD, any disease requiring oxygen use, neurological or hematological disease; cancer requiring treatment in past year, except non-melanoma skin cancers
- Serious conduction disorder, new Q waves or ST-segment depression (>3 mm), or uncontrolled arrhythmia
- Room air SpO2 (oxygen saturation) at rest or with exercise qualifying for supplementary oxygen (SpO2≤88%)
- Abnormal kidney or liver function (2x upper limit of normal);
- eGFR <45 mL/min/1.73m2
- Anemia (Hb<13 g/dL in men/ <12 g/dL in women);
- Uncontrolled diabetes (fasting glucose >140 mg/dl);
- Deficient levels of vitamin D (25 hydroxyvitamin D level < 20 ng/mL) in those not taking a vitamin D supplement;
- Smoker (No nicotine in past yr)
- No heavy alcohol use (>14 drinks/week)
- Unstable severe depression
- Regular use of: growth hormones, oral steroids, weight loss medications or prescription osteoporosis meds
- Current participation in other research study
Study Plan
How is the study designed?
Design Details
- Primary Purpose: PREVENTION
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: DOUBLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: Weight loss + sitless
All participants will undergo a dietary WL intervention designed to elicit behavioral changes leading to decreased caloric intake sufficient to yield a ~10% loss of initial body mass. Participants will be encouraged and taught to reduce sedentary behavior (SB) during waking hours. The SitLess treatment targets increases in postural shifts and light, spontaneous physical activity (SPA) (MET level <3). |
All participants will undergo a dietary WL intervention designed to elicit behavioral changes leading to decreased caloric intake sufficient to yield a ~10% loss of initial body mass.
The WL intervention includes nutrition education, state-of-the-art behavioral methods for promoting WL, and strategies that optimize self-regulation.
Other Names:
Encouraged and taught to reduce sedentary behavior (SB) during waking hours.
The SitLess treatment targets increases in postural shifts and light, spontaneous physical activity (SPA) (MET level <3).
Other Names:
|
Other: Weight loss + exercise
All participants will undergo a dietary WL intervention designed to elicit behavioral changes leading to decreased caloric intake sufficient to yield a ~10% loss of initial body mass. Participants will be asked to perform structured aerobic exercise (mostly treadmill walking) of moderate-intensity for 4-5 days/week, progressing to a duration of 200 min/week. |
All participants will undergo a dietary WL intervention designed to elicit behavioral changes leading to decreased caloric intake sufficient to yield a ~10% loss of initial body mass.
The WL intervention includes nutrition education, state-of-the-art behavioral methods for promoting WL, and strategies that optimize self-regulation.
Other Names:
Perform structured aerobic exercise (mostly treadmill walking) of moderate-intensity for 4-5 days/week, progressing to a duration of 200 min/week.
Participants will attend center-based sessions for at least 3 days/week during the first intensive 6-month phase and at least one day/week during the second 3-month transition phase (months 7-9), with recording of home-based exercise for the other 2-4 days/week.
Other Names:
|
Other: Weight loss + exercise + sitless
All participants will undergo a dietary WL intervention designed to elicit behavioral changes leading to decreased caloric intake sufficient to yield a ~10% loss of initial body mass. Participants will be encouraged and taught to reduce sedentary behavior (SB) during waking hours. The SitLess treatment targets increases in postural shifts and light, spontaneous physical activity (SPA) (MET level <3). Participants will be asked to perform structured aerobic exercise (mostly treadmill walking) of moderate-intensity for 4-5 days/week, progressing to a duration of 200 min/week. |
All participants will undergo a dietary WL intervention designed to elicit behavioral changes leading to decreased caloric intake sufficient to yield a ~10% loss of initial body mass.
The WL intervention includes nutrition education, state-of-the-art behavioral methods for promoting WL, and strategies that optimize self-regulation.
Other Names:
Encouraged and taught to reduce sedentary behavior (SB) during waking hours.
The SitLess treatment targets increases in postural shifts and light, spontaneous physical activity (SPA) (MET level <3).
Other Names:
Perform structured aerobic exercise (mostly treadmill walking) of moderate-intensity for 4-5 days/week, progressing to a duration of 200 min/week.
Participants will attend center-based sessions for at least 3 days/week during the first intensive 6-month phase and at least one day/week during the second 3-month transition phase (months 7-9), with recording of home-based exercise for the other 2-4 days/week.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Body Weight
Time Frame: Baseline
|
Measured in clinic on the same scale
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Baseline
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Body Weight
Time Frame: 6 months
|
Measured in clinic on the same scale
|
6 months
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Body Weight
Time Frame: 18 months
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Measured in clinic on the same scale
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18 months
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Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Functional Assessment of Chronic Illness Therapy (FACIT) Fatigue Scale
Time Frame: Baseline (0mo), 6mo, 18mo
|
13 item scale used to measure fatigue over the past week with a 4-point Likert scale.
The score range is 0-52 with a score of less than 30 indicating severe fatigue, and higher score denoting a better quality of life.
|
Baseline (0mo), 6mo, 18mo
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Patient-Reported Outcomes Measurement Information System (PROMIS) Short Form 8a
Time Frame: Baseline, 6mo, 18mo
|
DAn 8 item questionnaire that assess fatigue over the past 7 days.
All items are summed with the lowest possible score equaling 8 and the highest, a 40.
A higher score indicates more fatigue.
|
Baseline, 6mo, 18mo
|
Pittsburg Fatigability Questionnaire
Time Frame: Baseline, 6mo, 18mo
|
10 item scale that assesses fatigability (fatigue in the context of a standardized task). A higher score indicates a higher performance fatigability, slower gait speed, worsening physical function. A 10 item scale that assesses fatigability (fatigue in the context of a standardized task). Score range is 0-50 with a higher score = a higher performance fatigability, slower gait speed, worsening physical function. |
Baseline, 6mo, 18mo
|
Short Form 36 Item (SF-36) Health Survey
Time Frame: Baseline, 6mo, 18mo
|
A 36 item survey of overall health broken into 8 scaled scores of vitality, physical function, pain, general health, mental health, social, physical, and emotional role functioning.
Ranging from 0 to 100, the lower a person scores, the more disability.
|
Baseline, 6mo, 18mo
|
Self-Efficacy for Walking Scale
Time Frame: Baseline, 6mo, 18mo
|
Self-reported measure used to determine a person's belief in their physical capability to successfully complete incremental walking distances (5-40 minutes) at a moderate pace.
The total strength for each measure of self-efficacy is then calculated by summing the confidence ratings and dividing by the total number of items in the scale, resulting in a maximum possible efficacy score of 100.
|
Baseline, 6mo, 18mo
|
Satisfaction With Physical Function Questionnaire
Time Frame: Baseline, 6mo, 18mo
|
A scale testing how satisfied an individual is with their physical fitness and abilities.
Levels of satisfaction are rated on a 7 point scale from very dissatisfied to very satisfied.
All items are then averaged to create a score ranging from -3 to 3.
|
Baseline, 6mo, 18mo
|
Self-Efficacy for Managing Eating Questionnaire
Time Frame: Baseline, 6mo, 18mo
|
Used to measure self-efficacy for appropriate eating using 5 subscales (Negative Emotions, Availability, Social Pressure, Physical Discomfort, Positive Activities) of 4 items each (e.g., "I can resist eating even when high-calorie foods are available").
Item responses range from 0 (not confident) to 9 (very confident).
An average score is created for each subscale and then a total score by averaging across all items.
On a scale from 10 to 40, higher scores represent greater confidence in being able to restrain oneself from eating under difference contexts.
|
Baseline, 6mo, 18mo
|
Experiences in Close Relationships Questionnaire
Time Frame: Baseline, 6mo, 18mo
|
Scale used to evaluate the construct of adult attachment by examining avoidance and anxiety.
A person rates each statement about connection using a 7-point Likert scale which ranges from 1 (strongly disagree) to 7 (strongly agree).
To obtain score, average responses from all 36 items.
A score will range from 7 to 42 with a higher score representing insecure attachment.
|
Baseline, 6mo, 18mo
|
Mindful Attention Awareness Scale (MAAS)
Time Frame: Baseline, 6mo, 18mo
|
15-item questionnaire used to assess the core characteristic of mindfulness, or an awareness of and attention to what is taking place in the present.
The 15 items are collected in a Likert scale, totaled, and averaged for a final score ranging from 1-7.
A higher score reflects higher levels of mindfulness and a lower score is indicative of a negative emotional state.
|
Baseline, 6mo, 18mo
|
Power of Food Questionnaire
Time Frame: Baseline, 6mo, 18mo
|
Scale assessing the psychological impact of living in food-abundant environments.
It measures appetite for, rather than consumption of, palatable foods, at three levels of food proximity (food available, food present, and food tasted).
|
Baseline, 6mo, 18mo
|
Perceived Stress Scale
Time Frame: Baseline, 6mo, 18mo
|
A questionnaire used to measure the perception of stress and how often a person felt that way in the last month.
Individual scores range from 0 to 40 with higher scores indicating a person perceives higher levels of stress which could lead to or correlate with negative behaviors such as stress eating or decreases in physical activity
|
Baseline, 6mo, 18mo
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Food Cravings Questionnaire
Time Frame: Baseline, 6mo, 18mo
|
15-item measure of short-term changes in food cravings.
Responses are made on a five-point Likert scale with response categories ranging from 1 (strongly disagree) to 5 (strongly agree).
The scale yields a sum total from the five subscale scores, including, 1) an intense desire to eat; 2) anticipation of positive reinforcement that may result from eating; 3) anticipation of relief from negative states and feelings as a result of eating; 4) obsessive preoccupation with food or lack of control over eating; and 5) craving as a physiological state.
Sum scores range from 15 to 90 with higher scores representing more frequent and intense experiences of craving food.
|
Baseline, 6mo, 18mo
|
Technology Survey
Time Frame: 6mo, 18mo
|
Administered during assessment visits to gain insight on the participants' opinion of the technology (i.e., Empower application and web-based questionnaires, any tests/emails received from the Empower team) used in the study.
Examples of these open-ended questions include: 1) How useful did you find the Empower smartphone app?; 2) To what extent was the Empower app a burden to use?; 3) How difficult or easy was the app to use?; 4) How important did you feel the app was to your experience in the Empower study?; 5) What were one or two of your favorite and least favorite features of the Empower app? Questions were not scored or used in data analysis, but provided staff with an overall user opinion as well as constructive criticism in order to improve similar technologies in future studies.
|
6mo, 18mo
|
Intervention Survey
Time Frame: 6 mo, 18 mo
|
Administered at assessment visits to gain inside on the participants' opinion on the group dynamic used in the first 6 months of the study.
Examples of the dichotomous questions include: 1) Did you enjoy working with the staff and participants?; 2) Did you feel pressured by staff and or participants to do well in the study?; 3) Did you get along with the staff and participants in Empower?; 4) Did you feel comfortable expressing your ideas and opinions to staff members and fellow participants?; 5) Do you feel people a part of the Empower study care about you?
Questions were not scored or used in data analysis, but provided staff with an overall opinion of participant experience as well as constructive criticism in order to improve similar group settings in future studies.
|
6 mo, 18 mo
|
Anthropometric Measures
Time Frame: Baseline, 6mo, 18mo
|
Three anthropometric measures at three anatomical locations are taken using a handheld measuring table with tension and recorded in centimeters.
The waist measurement is taken at the narrowest part of the torso below the ribcage and above the umbilicus.
The hip measurement is measured at the maximal circumference of the buttocks.
The mid-thigh is taken with the knee bent to 90°, midway between the inguinal crease and the proximal border of the patella.
The measurements taken at each site are averaged.
A waist/hip ratio is calculated.
|
Baseline, 6mo, 18mo
|
Expanded Short Physical Performance Battery (eSPPB)
Time Frame: Baseline, 6mo, 18mo
|
Consists of a test of balance, gait speed test, and chair stand, performed in this order.
The following equipment is required for the expanded SPPB: digital stopwatch, masking tape, measuring tape, script, and a straight-backed armless chair with a hard seat.
To eliminate the effect of different footwear on test performance, tests are performed in tennis shoes or comfortable walking shoes with minimal or no heels.
Tests are individually scored 0-4 and then totaled for a maximal score of 12.
The higher a score, the better an individual's mobility and functional ability.
|
Baseline, 6mo, 18mo
|
Treadmill Fatigability
Time Frame: Baseline, 6mo, 18mo
|
Test is done on a treadmill to assess perceived fatigability at a given workload.
Participants are asked to rate their RPE (rating of perceived exertion) just as they start walking (0 min, 2.0 mph), half way through (2.5 min, 2.0 mph), and at the end of the test (5 min, 2.0 mph).
Heart rate via a heart rate monitoring watch will be recorded at these same intervals.
|
Baseline, 6mo, 18mo
|
Peak Aerobic Capacity (VO2) Peak
Time Frame: Baseline, 6mo, 18mo
|
Measured during a maximal graded exercise test (GXT) to exhaustion on a treadmill using a Raise, Activate, Mobilise, Potentiate (RAMP) protocol.
The GXT is used to rule out any latent coronary artery disease and to measure cardiovascular functional capacity and peak oxygen uptake.
The respiratory rate, minute ventilation, breathing reserve, VO2, Validation of Carbon Dioxide Production (VCO2), respiratory exchange ratio, one metabolic equivalent (MET) level, heart rate (HR), VO2/HR, kilocalorie/minutes (Kcal/min), Rating of Perceived Exertion (RPE) and Blood pressure (BP) at test conclusion are recorded.
|
Baseline, 6mo, 18mo
|
Grip Strength
Time Frame: Baseline, 6mo, 18mo
|
The Jaymar Handheld Dynamometer is used to measure grip strength in both hands.
To the nearest and highest kilogram achieved, hand grip strength is a commonly used measure of upper body skeletal muscle function and has been widely used as a general indicator of frailty with predictive validity for both mortality and functional limitation.
|
Baseline, 6mo, 18mo
|
Resting Metabolic Rate (RMR)
Time Frame: Baseline, 6mo, 18mo
|
A facemask will be placed on the participant while he/she is lying on the exam table.
Measures of oxygen consumption and carbon dioxide production will be collected continuously for 30 minutes and the RMR will be calculated using the Weir equation.
|
Baseline, 6mo, 18mo
|
Activity Monitor
Time Frame: Baseline, 6mo, 18mo
|
Used to evaluate time spent in sedentary behavior, light, and moderate to vigorous physical activity (MVPA).
An activPAL™ accelerometer (PAL Technologies, Glasgow, Scotland) is worn for 7-days at each of the three assessment visits: baseline, 6-months and 18-months.
The monitor uses accelerometer-derived information about thigh position to estimate time spent in different body positions: lying or sitting = sedentary; standing still; and stepping = light and MVPA.
Data is downloaded at the end of each 7-day period and cleaned and summarized for statistical analyses.
The proprietary algorithm in the activPAL software is used to generate estimates of (a) Total Daily Energy Expenditure (TDEE); (b) sedentary time during the day, (c) number of breaks in sedentary time, (d) minutes spent in light activity, and (e) number of minutes spent in MVPA.
|
Baseline, 6mo, 18mo
|
Ecological Momentary Assessment (EMA)
Time Frame: Baseline, 6mo
|
Used to determine the relationship between dynamic food variables, physical activity variables, and long-term weight loss.
Prior to the start of the intervention and following the initial intervention period, participants complete week-long daily assessments.
The following are the different scales and questions asked of participants: 1) Affective Valence from the Feelings Scale (scored 0 - 10 where 0 = very bad and 10 = very good).
2) Six items from the exercise-induced feelings inventory, each on a 0 ="do not feel" to 10="feel very strongly" score.
Calm, peaceful, and relaxed are then averaged for a "tranquility" subscale; "fatigued, "tired" and "worn-out" are averaged for a physical exhaustion subscale.
3) Hunger was queried by "How hungry are you right now?" where 0 = not at all hungry, and 10 = very hungry.
4) An individual's craving for food was queried by "How much do you crave eating your favorite food or snack right now?" where 0 = "do not feel" and 10 = "feel very strongly".
|
Baseline, 6mo
|
400 Meter Walk Test
Time Frame: Baseline, 6mo, 18mo
|
Test is completed at a quick pace (without running) that the participant can maintain over the flat, 400 meter course.
Timing begins when the participant takes his/her first step.
Timing ends when the participant's whole foot crosses the line at the end of the 10th lap or the participant requests to stop.
Recorded is the distance completed and time walked in minutes and seconds.
|
Baseline, 6mo, 18mo
|
Walking Efficiency
Time Frame: Baseline, 6mo, 18mo
|
Used to determine the number of calories burned while walking at 2.0 mph on a treadmill with zero grade.
Heart rate (HR) is measured continuously using a heart rate monitoring watch and will be recorded every minute.
Blood pressure (BP) is monitored and recorded every minute.
The test is terminated when the (HR) remains at a steady state (is within 5 beats per minute of the HR from the previous minute).
The time to achieve steady state heart rate, the respiratory rate, minute ventilation, breathing reserve, VO2, VCO2, respiratory exchange ratio, MET level, HR, VO2/HR, Kcal/min, and the BP at steady state are recorded.
|
Baseline, 6mo, 18mo
|
Visceral Fat
Time Frame: Baseline, 6mo, 18mo
|
A visceral fat measurement is obtained through a dual-energy X-ray absorptiometry (DEXA) whole body scan in a 5-cm wide region across the entire abdomen just above the iliac crest at a level approximate with the 4th lumbar vertebrae.
Mass visceral fat is measured to the nearest gram and volume to the nearest centimeter.
|
Baseline, 6mo, 18mo
|
Bone Mineral Density (BMD)
Time Frame: Baseline, 6mo, 18mo
|
Hip and spine BMD is measured using specific scans of the anterior-posterior spine Lumbar vertebrae 1-Lumbar vertebrae 4 (L1-L4) and proximal femur by dual-energy X-ray absorptiometry.
BMD is recorded as a t-score with a lower score indicative of less bone density and increased risk for osteoporosis.
|
Baseline, 6mo, 18mo
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Cardiometabolic Risk Factors--Lab Work
Time Frame: Baseline, 6mo, 18mo
|
An 8-hour fasting venous blood sample is collected to measure cardiometabolic changes lipoprotein lipids, C-reactive protein, HbA1c, glucose and insulin.
|
Baseline, 6mo, 18mo
|
Satisfaction With Physical Function
Time Frame: Baseline, 6mo, 18mo
|
Scale used to test how satisfied participants are with their physical fitness, functional ability, and physical appearance.
Participants rate their level of satisfaction on a 7-point scale from very dissatisfied to very satisfied.
Average all items to create a score ranging from -3 to 3. Higher values represent greater satisfaction with physical function and importance.
|
Baseline, 6mo, 18mo
|
Collaborators and Investigators
Publications and helpful links
General Publications
- Burdette JH, Laurienti PJ, Miron LL, Bahrami M, Simpson SL, Nicklas BJ, Fanning J, Rejeski WJ. Functional Brain Networks: Unique Patterns with Hedonic Appetite and Confidence to Resist Eating in Older Adults with Obesity. Obesity (Silver Spring). 2020 Dec;28(12):2379-2388. doi: 10.1002/oby.23004. Epub 2020 Nov 1.
- Fanning J, Opina MT, Leng I, Lyles MF, Nicklas BJ, Rejeski WJ. Empowered with Movement to Prevent Obesity & Weight Regain (EMPOWER): Design and methods. Contemp Clin Trials. 2018 Sep;72:35-42. doi: 10.1016/j.cct.2018.07.010. Epub 2018 Jul 17.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- IRB00035300
- R01AG051624 (U.S. NIH Grant/Contract)
- R01AG051624-02S1 (U.S. NIH Grant/Contract)
- R01AG051624-02S2 (U.S. NIH Grant/Contract)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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