Glucose Response From Antioxidant Rich Potato Chips

October 5, 2016 updated by: Richard Mattes, Purdue University
Assess impact of potato phytochemical on post-prandial gastric emptying and glucose release from products in a pilot human study.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Preclinical data obtained using an Caco-2 intestinal cell model and enzyme assays suggest phenolic-rich potato extracts decrease intestinal glucose transport. The aim is to determine if these effects extend to the the an in vivo situation. Specifically, the glycemic response following consumption of phenolic rich pigmented potatoes compared to white potatoes with lower phenolic content will be measured. Gastric emptying will also be measured to show the effects are in fact due to rate of carbohydrate digestion and intestinal glucose transport and not gastric emptying rate.

Study Type

Interventional

Enrollment (Actual)

11

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 50 years (ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • BMI 18-25 non-smoker

Exclusion Criteria:

  • BMI outside 18-25 smoker previous gastrointestinal disease or other disease

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: BASIC_SCIENCE
  • Allocation: RANDOMIZED
  • Interventional Model: CROSSOVER
  • Masking: SINGLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: Purple Majesty potato chips
Other: Purple Majesty potato chips
Purple Majesty potato chips
EXPERIMENTAL: Mountain Rose potato chips
Other: Mountain Rose potato chips
Mountain Rose potato chips
EXPERIMENTAL: White potato chips
Other: White potato chips
White potato chips
EXPERIMENTAL: Crackers
Other: Crackers
Crackers

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Blood Glucose
Time Frame: up to 2 hours
blood taken at 10, 20, 30, 60, and 120 minutes by finger prick
up to 2 hours
Gastric emptying
Time Frame: up to 4 hours
Breath Hydrogen concentrations will be measured every 15 minutes for 4 hours
up to 4 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Purdue University

Collaborators

PepsiCo Global R&D

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2016

Primary Completion (ACTUAL)

February 1, 2016

Study Completion (ACTUAL)

June 1, 2016

Study Registration Dates

First Submitted

October 4, 2016

First Submitted That Met QC Criteria

October 5, 2016

First Posted (ESTIMATE)

October 6, 2016

Study Record Updates

Last Update Posted (ESTIMATE)

October 6, 2016

Last Update Submitted That Met QC Criteria

October 5, 2016

Last Verified

October 1, 2016

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 055-043

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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