Effects of Essence of Chicken on Physical Fatigue, Working Memory and Attention

Effects of the Supplementation of Essence of Chicken on Physical Fatigue and Brain Functions Such as Working Memory and Attention Among Healthy Adults

In Southeast Asia, Essence of Chicken, a chicken-meat-extract, is a popular beverage and is consumed as a traditional remedy for several ailments, including the use as a nutritional supplement for sickness, enhancement of mental efficiency, and recovery from mental fatigue. While the elderly use it as a nutritional supplement, students use it for relief from anxiety during exam times.

The present study is conducted in order to assess the effects of BEC on various physical and mental parameters including physical fatigue, working memory and attention, mood and stress, in comparison to placebo.

Study Overview

• Status: Completed
• Conditions: Fatigue; Healthy Subjects
• Intervention / Treatment: Dietary supplement: Essence of Chicken; Dietary supplement: Placebo (Energy matched)

• Study Type: Interventional
• Enrollment (Actual): 364
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 14 years to 41 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Normal BMI
• Not continuously taken Essence of Chicken for the last 3 months
• Physical and psychological fatigue inclusion criteria/test/cutoff using CFQ (where individuals' CFQ scores 4 or above)

Exclusion Criteria:

• Suffering from chronic or malignant diseases e.g. cancer, heart, liver, renal or other metabolic diseases.
• Any psychiatric or neurological disease
• Pregnant and lactating women
• Subjects participated in any investigational drug trial within 4 weeks before screening
• Consumption of food supplement in the previous 2 weeks
• Professional athletes
• Subjects with recent lifestyle changes in the past 4 weeks
• History of allergy to chicken meat and seafood

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Quadruple

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo	Dietary supplement: Placebo (Energy matched)
Active Comparator: 1 bottle	Dietary supplement: Essence of Chicken; Brand's Essence of Chicken (BEC) is produced via a water extraction process from chicken meat for several hours under high-temperature, followed by centrifugation to remove fat and cholesterol, vacuum concentration to 3- to 4-fold, sterilization by high temperature and pressure before bottling. This kind of chicken essence is rich in protein, and low in sugar and fat, conveniently available and consumable, and easy for household storage.
Active Comparator: 2 bottles	Dietary supplement: Essence of Chicken; Brand's Essence of Chicken (BEC) is produced via a water extraction process from chicken meat for several hours under high-temperature, followed by centrifugation to remove fat and cholesterol, vacuum concentration to 3- to 4-fold, sterilization by high temperature and pressure before bottling. This kind of chicken essence is rich in protein, and low in sugar and fat, conveniently available and consumable, and easy for household storage.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Fatigue-vitality	Psychometric tests SF-36 (score 100%)	4 weeks
Physical fatigue	Chalder Fatigue Questionnaire (score 0-33)	4 weeks
Attention	Stroop (mean latency and proportion correct)	4 weeks
Sustained attention	Sustained Attention to Response Task (mean latency and % of correct trials)	4 weeks
Working memory	Digit Span test (Maximal FORWARD digit span and Maximal BACKWARD digit span, etc)	4 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mood	POMS brief is used as a psychometric test to measure mood (6 domains).	4 weeks
Stress	DASS is used as a psychometric test to measure stress (score 0-42).	4 weeks
Adverse effects	Comparison of adverse events on IP and placebo groups.	4 weeks

Collaborators and Investigators

• Sponsor: Sprim Advanced Life Sciences
• Collaborators: Cerebos

Study record dates

Study Major Dates

• Study Start (Actual): March 3, 2016
• Primary Completion (Actual): November 7, 2016
• Study Completion (Actual): January 30, 2017

Study Registration Dates

• First Submitted: February 20, 2017
• First Submitted That Met QC Criteria: April 20, 2017
• First Posted (Actual): April 25, 2017

Study Record Updates

• Last Update Posted (Actual): April 25, 2017
• Last Update Submitted That Met QC Criteria: April 20, 2017
• Last Verified: February 1, 2017

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Fatigue
• Other Study ID Numbers: BEC

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No