Efficacy of Injectable Vitamin C on Accelerating Canine Movement: A Clinical Study (mesotherapy)

August 25, 2017 updated by: nermin mohammed ahmed yussif, Cairo University

Evaluation of the Effect of Local Injected Vitamin C on Accelerating the Orthodontic Movement of Maxillary Canine Impaction: A Clinical Trial

efficacy of the injectable vitamin C to reduce the time of canine traction

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Objective. The purpose of this study is to investigate the role and efficiency of the locally injected vitamin C in the enhancement of the palatally impacted canine movement.

Design. Twelve adult patients with unilateral palatally impacted canines were included in this study. The enrolled patients were randomly allocated into the study groups; control group; orthodontic traction and he test group: orthodontic traction enhanced by intraepidermic vitamin C injection. The study duration was 12 months.

Study Type

Interventional

Enrollment (Actual)

12

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
    • Giza
      • Gizah, Giza, Egypt, 11311
        • Faculty of Oral and Dental Medicine

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

15 years to 40 years (ADULT, CHILD)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • medically free
  • patient with good to fair oral hygiene (gingivitis may be included)
  • both sexes were included
  • unilateral palatally positioned permenant canines
  • absence of previous orthodontic treatment
  • absence of supernumerary teeth, odontoms, cysts, traumatic injuries
  • the α angle within grade II to III

Exclusion Criteria:

  • systemic diseases especially diabetes and bone diseases
  • pregnant and lactating mothers
  • Local causes (smoking, mouth breathing, local trauma and periodontitis).

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: TREATMENT
  • Allocation: NON_RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: SINGLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
ACTIVE_COMPARATOR: vitamin C injection
orthodontic traction with vitamin C injection
Drug: vitamin C
25 IU of vitamin C injected intraepidermally for 6-8 visits till eruption achieved
Other Names:
  • ascorbic acid
PLACEBO_COMPARATOR: orthodontic traction
orthodontic traction without vitamin C injection
Drug: vitamin C
25 IU of vitamin C injected intraepidermally for 6-8 visits till eruption achieved
Other Names:
  • ascorbic acid

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
rate of tooth movement
Time Frame: 12 months
the achieved movement in millimeters in one year
12 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
level of alveolar bone
Time Frame: 12 months
the level of the interproximal and facial alveolar bone after orthodontic treatment with or without injection
12 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Cairo University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2014

Primary Completion (ACTUAL)

January 1, 2015

Study Completion (ACTUAL)

February 1, 2015

Study Registration Dates

First Submitted

January 11, 2017

First Submitted That Met QC Criteria

August 23, 2017

First Posted (ACTUAL)

August 24, 2017

Study Record Updates

Last Update Posted (ACTUAL)

August 29, 2017

Last Update Submitted That Met QC Criteria

August 25, 2017

Last Verified

August 1, 2017

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • oral and dental medicine
  • no conflict of interest (OTHER)

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Palatally Impacted Canines

Clinical Trials on vitamin C

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Benin

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe