Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight

Saturated Fatty Acids Intake and Mortality, Diabetes, Hypertension and Overweight in the China Health and Nutrition Survey (CHNS)

The role of saturated fatty acids (SFAs) intake in the development of total death, cardiovascular diseases, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is scant.The investigators aim to use the data from the China Health and Nutrition Survey to assess the long-term association of SFAs intake with total mortality, diabetes, hypertension and overweight.

Study Overview

• Status: Completed
• Conditions: Hypertension; Diabetes; Overweight; Morality

Detailed Description

The role of saturated fatty acids (SFAs) intake in the development of total death, diabetes, hypertension and overweight are in great controversy but evidence from large population in China is lacking.The investigators aim to utilize the data from the China Health and Nutrition Survey. The investigators will calculate the cumulative average intake of SFAs based on 3 consecutive 24-h dietary recalls in each round.Sex-specific Cox regression models will be used to estimate the relative risk.Results from our work will be used to provide epidemiological evidence for improving recommendation on SFAs intake for Chinese in dietary guidelines.

• Study Type: Observational
• Enrollment (Actual): 14383

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

CHNS is an ongoing, large-scale, household-based cohort starting in 1989. The survey used a multi-stage, random cluster process to draw a sample of 9 provinces and municipal cities, which take up about half of Chinese population.

Description

Inclusion Criteria:

• Adults aged ≥20 with complete data on diet and follow-up time

Exclusion Criteria:

• Cardiovascular diseases
• Diabetes (for analyses of diabetes)
• Body mass index ≥ 24 kg/㎡ (for analyses of overweight)
• Hypertension (for analyses of hypertension)

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mortality	Incidence of all-cause death, on basis of household members' report	From baseline until death or censoring on 31 December 2011, whichever came first, assessed up to an average of 10 years
Diabetes	Incidence of diabetes, on basis of self-reported physician diagnosis, fasting plasma glucose ≥ 7.0 mmol/l or HbA1c ≥ 6.5%	From entry into the study (baseline: 1997-2009) until 2011

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Saturated fatty acids intake	Cumulative average intake of saturated fatty acids on basis of 3 consecutive 24-h dietary recalls	From entry into the study (baseline: 1997-2009) until 2011
Hypertension	Incidence of hypertension, on basis of self-reported physician diagnosis, systolic pressure ≥ 140 mmHg or diastolic pressure ≥ 90 mmHg	From entry into the study (baseline: 1997-2009) until 2011
Overweight	Incidence of overweight, on basis of body mass index (BMI), BMI ≥ 24 kg/㎡	From entry into the study (baseline: 1997-2009) until 2011

Collaborators and Investigators

• Sponsor: Zhejiang University
• Collaborators: National Institute of Health and Nutrition

Publications and helpful links

General Publications

• Zhuang P, Cheng L, Wang J, Zhang Y, Jiao J. Saturated Fatty Acid Intake Is Associated with Total Mortality in a Nationwide Cohort Study. J Nutr. 2019 Jan 1;149(1):68-77. doi: 10.1093/jn/nxy237.

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 1989
• Primary Completion (Actual): December 31, 2011
• Study Completion (Actual): December 31, 2012

Study Registration Dates

• First Submitted: September 11, 2017
• First Submitted That Met QC Criteria: September 11, 2017
• First Posted (Actual): September 13, 2017

Study Record Updates

• Last Update Posted (Actual): March 15, 2024
• Last Update Submitted That Met QC Criteria: March 12, 2024
• Last Verified: March 1, 2024

More Information

Terms related to this study

• Keywords: Saturated fatty acids; CHNS
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases; Overnutrition; Nutrition Disorders; Body Weight; Hypertension; Diabetes Mellitus; Overweight
• Other Study ID Numbers: Cohort_SFA

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No