The Effect of Positive End Expiratory Pressure on Central Venous Pressure Among Patients With Different Lung Compliance

November 13, 2017 updated by: Jingyuan,Xu
To observe the effect of PEEP on CVP among patients with different respiratory compliance

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

30 patients with mechanical ventilation and inserted central venous line will be entered. After gathering demographic data, patients undergone 5,10 and 15cmH2O PEEPs and the respective CVPs of the mentioned points will be recorded. According to the change of CVP, the patients will be divided into high response group and low response group, then comparing the lung compliance and thorax elastic resistance differences between the two groups.

Study Type

Interventional

Enrollment (Anticipated)

30

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Jiangsu
      • Nanjing, Jiangsu, China, 210000
        • Recruiting
        • Zhongda Hospital
        • Principal Investigator:
          • chenglong liang, master

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 80 years (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

1. Patients with mechanical ventilation and inserted central venous line

Exclusion Criteria:

  1. The age is less than 18 years old or more than 80 years old；
  2. Pregnant and lying-in woman；
  3. Patients undergoing fluid resuscitation and the speed is more than 200ml/h；
  4. Patients with norepinephrine dose are greater than 15 micro per minute；
  5. Patients with pericarditis、pulmonary heart disease、right heart failure、atrial fibrillation；
  6. Patients with COPD(endogenous PEEP is more than 2cmH2O)、tension pneumonthorax、acute episode asthma

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: SUPPORTIVE_CARE
  • Allocation: NON_RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: high response group
patients undergo 5,10 and 15cmH2O positive end expiratory pressure ,the change of central venous pressure is more than 2.5cmH2O
Other: 5,10 and 15cmH2O positive end expiratory pressure
every patients undergo 5,10 and 15cmH2O positive end expiratory pressure,and observe the central venous pressure of the mentioned points
PLACEBO_COMPARATOR: low response group
the change of CVP is less than 2.5cmH2O
Other: 5,10 and 15cmH2O positive end expiratory pressure
every patients undergo 5,10 and 15cmH2O positive end expiratory pressure,and observe the central venous pressure of the mentioned points

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
CVP
Time Frame: half an hour
Measure the central venous pressure of the three level PEEPs of 5,10 and 15cmH2O.
half an hour

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Jingyuan,Xu

Investigators

  • Study Chair: yi yang, doctor, Zhongda Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ANTICIPATED)

November 13, 2017

Primary Completion (ANTICIPATED)

December 30, 2017

Study Completion (ANTICIPATED)

December 30, 2017

Study Registration Dates

First Submitted

November 8, 2017

First Submitted That Met QC Criteria

November 13, 2017

First Posted (ACTUAL)

November 14, 2017

Study Record Updates

Last Update Posted (ACTUAL)

November 14, 2017

Last Update Submitted That Met QC Criteria

November 13, 2017

Last Verified

November 1, 2017

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2017ZDSYLL094-P01

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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