miRNA Profile in Aneurysmal Subarachnoid Haemorrhage (miRNA)

September 6, 2023 updated by: George KC Wong, Chinese University of Hong Kong

Circulating and CSF miRNA Profile in Patients With Acute Aneurysmal Subarachnoid Haemorrhage

The investigators aim to investigate and understand the circulating miRNA profiles after acute aneurysmal subarachnoid haemorrhage and underlying pathological significance.

Study Overview

Status

Completed

Conditions

Detailed Description

  1. The investigators aim to investigate the miRNA classifier for delayed cerebral infarction after aneurysmal subarachnoid haemorrhage;
  2. The investigators aim to investigate the corresponding circulating and CSF miRNA profiles.

Study Type

Observational

Enrollment (Actual)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • China
      • Hong Kong, China
        • Department of Surgery, The Chinese University of Hong Kong

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

21 years to 75 years (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

  • Acute aneurysmal subarachnoid hemorrhage patients with and without delayed cerebral infarction
  • Healthy volunteers

Description

Inclusion Criteria:

Aneurysmal subarachnoid hemorrhage patients within the first 72 hours or Healthy volunteers

Exclusion Criteria:

Previous neurological diseases such as stroke or dementia

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Control
Healthy volunteers
SAH with DCI
Aneurysmal subarachnoid haemorrhage patients with delayed cerebral infarction
SAH nonDCI
Aneurysmal subarachnoid haemorrhage patients without delayed cerebral infarction

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Circulating micro RNA concentrations
Time Frame: Day 3
Serum micro RNA concentrations
Day 3

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Circulating micro RNA change
Time Frame: Days 1,2,3,7
Changes of serum micro RNA concentrations between days 1,2,3,7
Days 1,2,3,7
Cerebrospinal fluid micro RNA concentrations
Time Frame: Day 1,2,3,7
Cerebrospinal fluid micro RNA concentrations
Day 1,2,3,7
Cerebrospinal fluid micro RNA change
Time Frame: Days 1,2,3,7
Changes of cerebrospinal fluid micro RNA concentrations between days 1,2,3,7
Days 1,2,3,7

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Chinese University of Hong Kong

Investigators

  • Principal Investigator: George KC Wong, Chinese University of Hong Kong

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 30, 2017

Primary Completion (Actual)

August 31, 2023

Study Completion (Actual)

August 31, 2023

Study Registration Dates

First Submitted

October 12, 2017

First Submitted That Met QC Criteria

November 13, 2017

First Posted (Actual)

November 17, 2017

Study Record Updates

Last Update Posted (Actual)

September 7, 2023

Last Update Submitted That Met QC Criteria

September 6, 2023

Last Verified

September 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • miSAH003

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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