Food Preference Following Bariatric Surgery

Roux-en-Y gastric bypass (RYGB) decreases appetite, caloric intake, glycemia, and body weight, all of which are maintained long term.It is controversial whether, after RYGB, patients choose to eat less high fat and sugary foods in favor of lower energy dense alternatives. Therefore the proposition to use direct measures in humans after RYGB to test the hypothesis that the selection and intake of foods varying in fat content and glycemic index, as well as the pattern of ingestion within and across meals, changes in a manner that leads to beneficial outcomes on body weight.

Study Overview

• Status: Completed
• Conditions: Obesity
• Intervention / Treatment: Behavioral: Food Preference

Detailed Description

Roux-en-Y gastric bypass (RYGB) decreases appetite, caloric intake, glycemia, and body weight, all of which are maintained long term.It is controversial whether, after RYGB, patients choose to eat less high fat and sugary foods in favor of lower energy dense alternatives. If true, this could conceivably contribute to improved glycemia and body weight. Disparities among studies on food selection and intake are likely due to the almost complete reliance on self-reported food intake which is vulnerable to inaccuracy.This controversy can best be resolved by complementing existing findings with direct measures of target behaviour in humans. Therefore the proposition to use direct measures in humans after RYGB to test the hypothesis that the selection and intake of foods varying in fat content and glycemic index, as well as the pattern of ingestion within and across meals, changes in a manner that leads to beneficial outcomes on body weight.

• Study Type: Observational
• Enrollment (Actual): 34

Contacts and Locations

Study Locations

• Ireland
  • Dublin, Ireland
    • University College Dublin

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Patients with obesity attending a specialist obesity clinic and free living individuals.

Description

Inclusion Criteria:

1. Surgical and non-surgical groups:

   A) Bariatric surgery B) Controls with no history of bariatric surgery

2. Independently mobile
3. Capacity to consent to participate
4. >18 years of age

Exclusion Criteria:

1. Pre-operatively: significant dysphagia, gastric outlet obstruction or anything that prevents subjects from eating a meal.
2. Post-operatively: significant and persistent surgical complications or anything that prevents subjects from eating a meal.

3. Systemic or gastrointestinal condition which may affect food intake or preference, including:

   i) pregnancy or ii) breast feeding.

4. Active and significant psychiatric illness including substance misuse
5. Significant cognitive or communication issues
6. Medications with documented effect on food intake or food preference
7. History of significant food allergy and certain dietary restrictions
8. History of liver disease or pancreatitis
9. History of bradyarrythmia or congestive cardiac failure group)
10. Use of medications with potential serious interactions with Octreotide

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Gastric bypass; Obese patients due to undergo gastric bypass surgery	Behavioral: Food Preference; Buffet meal to assess food preference
Control; Healthy free-living individuals	Behavioral: Food Preference; Buffet meal to assess food preference

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Total Food Intake (Lunch Buffet) at 24 Months	Determine the effect of RYGB on total food intake from an ad libitum lunch buffet	24 months
Change in Absolute Intake of Fat	Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of fat from an ad libitum lunch buffet	24 months
Change in Absolute Intake of Carbohydrates	Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of carbohydrates from an ad libitum lunch buffet	24 months
Change in Absolute Intake of Sugar	Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of sugar from an ad libitum lunch buffet	24 months
Change in Absolute Intake of Protein	Determine the effect of RYGB on food preferences by measuring the absolute i.e. total intake of protein from an ad libitum lunch buffet	24 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Gut Hormones	Determine if the changes in food preference following RYGB are mediated through changes in gut peptide following surgery.	2 weeks pre surgery and 3, 12 (two occasions) and 24 months post surgery and matched visits for controls
Octreotide	Determine the effect of gut hormone suppression (octreotide) on ad libitum macronutrient intake	12 months post surgery and time matched controls at two occasions

Collaborators and Investigators

• Sponsor: Imperial College London
• Investigators: Principal Investigator: Carel le Roux, MBChB, PhD, Imperial College London

Study record dates

Study Major Dates

• Study Start (Actual): December 15, 2017
• Primary Completion (Actual): September 30, 2021
• Study Completion (Actual): September 30, 2021

Study Registration Dates

• First Submitted: August 9, 2017
• First Submitted That Met QC Criteria: December 5, 2017
• First Posted (Actual): December 6, 2017

Study Record Updates

• Last Update Posted (Actual): August 8, 2023
• Last Update Submitted That Met QC Criteria: October 3, 2022
• Last Verified: October 1, 2022

More Information

Terms related to this study

• Keywords: Weight loss; Fat; Food preferences
• Other Study ID Numbers: GutHormoneStudy

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No