Hypoglycemic and Hyperglycemic Disorders

Glycemic Disorders in Low Birth Weight Babies

Definition of low birth weight:

Low birth weight infants are those born weighing less than 2500 g. These are further subdivided into:

• Very Low Birth Weight : Birth weight <1,500 g
• Extremely Low Birth Weight : Birth weight <1,000 g Their survival is directly related to birth weight, with approximately 20% of those between 500 and 600 g and>90% of those between 1,250 and 1,500 g surviving. Perinatalcare has improved the rate of survival of low birth weight infants.

Study Overview

• Status: Unknown
• Conditions: Hyperglycemia; Hypoglycemia in Newborn Infants
• Intervention / Treatment: Diagnostic test: random blood sugar

Detailed Description

Causes of low birth weight:

• Premature birth
• Intrauterine growth restriction, which are most often Due to different placental problems and health problems of the mother or new-born

RISK FACTORS:

• Age: Teen mothers have a much higher risk of having VLBW infant.
• Multiple birth babies are at increased risk of being VLBW because they often are premature. More than 50% of twins and other multiple gestations are VLBW if <15 years
• Maternal health: Women exposed to drugs, alcohol, and cigarettes during pregnancy are more likely to have low birth weight babies. Mothers of lower socioeconomic
• Race: African-American babies are twice as likely as Caucasian to be very low birth weight

• Study Type: Observational
• Enrollment (Anticipated): 100

Contacts and Locations

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: No older than 4 weeks (Child)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

all low birth weight babies

Description

Inclusion Criteria:

• All neonates admitted to neonatology unit

  1. From 0-28 days
  2. Weighting less than 2500gm

Exclusion Criteria:

• Any neonate weighting more than 2500 gm

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
glycemic disorders in low birth weight	to detect the prevelance of hypoglycemia and hyperglycemia in low birth weight babies by random blood sugar test	one year

Collaborators and Investigators

• Sponsor: Assiut University

Publications and helpful links

General Publications

• Abdulkadir I, Hassan L, Abdullahi F, Sobowale AM, Akeredolu FD, Purdue S, Okpe M, Adewumi OA, Abdullahi U, Onadiran MA, Ogala WN. Outcome of Extremely Low Birth Weight Babies in Zaria; A Ten-Year Review. West Afr J Med. 2015 Jan-Mar;34(1):50-4.
• Hays SP, Smith EO, Sunehag AL. Hyperglycemia is a risk factor for early death and morbidity in extremely low birth-weight infants. Pediatrics. 2006 Nov;118(5):1811-8. doi: 10.1542/peds.2006-0628.
• Rozance PJ, Hay WW Jr. New approaches to management of neonatal hypoglycemia. Matern Health Neonatol Perinatol. 2016 May 10;2:3. doi: 10.1186/s40748-016-0031-z. eCollection 2016.
• Eichenwald EC, Stark AR. Management and outcomes of very low birth weight. N Engl J Med. 2008 Apr 17;358(16):1700-11. doi: 10.1056/NEJMra0707601. No abstract available.

Study record dates

Study Major Dates

• Study Start (Anticipated): December 15, 2018
• Primary Completion (Anticipated): October 20, 2019
• Study Completion (Anticipated): December 31, 2019

Study Registration Dates

• First Submitted: February 22, 2018
• First Submitted That Met QC Criteria: February 27, 2018
• First Posted (Actual): February 28, 2018

Study Record Updates

• Last Update Posted (Actual): February 28, 2018
• Last Update Submitted That Met QC Criteria: February 27, 2018
• Last Verified: February 1, 2018

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Hyperglycemia; Hypoglycemia
• Other Study ID Numbers: NGD

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No