Motor Interference Therapy For Traumatic Memories (TIMCO)

The Effect of Motor Interference Therapy In Traumatic Memories: A Controlled Clinical Trial

The aim of the study is to compare the effect of motor interference therapy (TIM) to reduce the intensity of discomfort (distress) generated by a traumatic memory compared to a relaxation control maneuver, immediately after the intervention, a week, a month and six months after intervention.

Study Overview

• Status: Completed
• Conditions: Post Traumatic Stress Disorder; Trauma, Psychological
• Intervention / Treatment: Other: motor interference therapy; Other: Relaxation exercises

Detailed Description

The investigators treated 10 patients with autobiographical traumatic memories using finger tapping tasks, (Motor Interference Therapy <TIM>)in a pilot study with amazing results and a solid size effect. The investigators decided to challenge the intervention using a control task (Jacobson´s progressive relaxation exercises) The hypothesis consists in achieving a 30% reduction of the distress, (measured with Visual Analogue Scale) by using TIM compared with the control task. Patients with traumatic memories will be enrolled in to one of two treatment modalities. The first group will receIve motor interference therapy and the second group will receive a control task (relaxation exercises). Both groups will be assessed using the Spanish version of the PTSD Symptom Severity Scale-Revised (EGS-R), the visual analogue scale (EQ-VAS) from EuroQol 5D (EQ-5D), and a simple visual-analogue scale (VAS) immediately after, a week after, a month after and six months after the treatment for follow up.

• Study Type: Interventional
• Enrollment (Actual): 28
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Mexico
  • Ciudad De Mexico
    • Mexico, Ciudad De Mexico, Mexico, 14269
      • Instituto Nacional de Neurologia Y Neurocirugia Mvs

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 16 years and older (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Patients older than 16 years
• Spanish as a native language
• Give written informed consent
• having at least 1 traumatic memory causing distress

Exclusion Criteria:

• Neurological or psychiatric disorders that affect the capacity of verbal comprehension and judgment, such as dementia, psychosis, mental retardation or other cognitive alteration that does not allow them to perform the tasks indicated in the TIM or SHAM
• History of recent substance abuse
• Patients with significant hearing loss or some other hearing impairment

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Motor Interference Therapy; Initial interview applying the Spanish version of the PTSD Symptom Severity Scale-Revised (EGS-R), the visual analogue scale (EQ-VAS) from EuroQol 5D (EQ-5D), and a simple visual-analogue scale (VAS). After that, patients will listen to an audio track twice and follow the instructions. The first four minutes of the audio track instruct the subjects to tap their fingers in response to specific sounds. During the remaining ten minutes, the patients will be asked to recall a traumatic memory while simultaneously are tapping their fingers. Patients must complete at least 80% of the motor task in order to be included. We will reassess a week, a month and six months after the intervention, using all three scales.	Other: motor interference therapy; Other Names: TIM
Sham Comparator: Relaxation Exercise; Initial interview applying the Spanish version of the PTSD Symptom Severity Scale-Revised (EGS-R), the visual analogue scale (EQ-VAS) from EuroQol 5D (EQ-5D), and a simple visual-analogue scale (VAS). After that, patients will listen to an audio track twice and follow the instructions. The first four minutes of the audio track instruct the subjects in how to do the exercises. During the remaining 10 minutes will hear commands for performing progressive muscle tension-relaxation exercises while the patient evoked the traumatic memory. Patients must complete at least 80% of the motor task in order to be included. We will reassess a week, a month and six months after the intervention, using all three scales.	Other: Relaxation exercises; In a top-down sequence, beginning with the upper body and proceeding to the lower parts. patients contract and relax a specific muscle group following the instructions given by the audio track. We use a shorter version that excludes the legs because of the time.; Other Names: Jacobson´s progressive relaxation

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change in Visual Analogue Scale (EVA)	measures the distress related to traumatic memories in 1-10	baseline, immediately, 1 week, 1 month, 6 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Spanish version of the PTSD Symptom Severity Scale-Revised (EGS-R)	Posttraumatic stress disorder scale	baseline, 1 week, 1 month, 6 months
visual analogue scale (EQ-VAS) from EuroQol 5D (EQ-5D)	as a gauge of health-related quality of lif	baseline, 1 week, 1 month, 6 months

Collaborators and Investigators

• Sponsor: El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez
• Investigators: Principal Investigator: Edgar D Crail-Melendez, MD, El Instituto Nacional de Neurologia y Neurocirugia Manuel Velasco Suarez

Study record dates

Study Major Dates

• Study Start (Actual): March 1, 2016
• Primary Completion (Actual): March 30, 2019
• Study Completion (Actual): December 31, 2019

Study Registration Dates

• First Submitted: August 8, 2018
• First Submitted That Met QC Criteria: August 8, 2018
• First Posted (Actual): August 13, 2018

Study Record Updates

• Last Update Posted (Actual): July 29, 2020
• Last Update Submitted That Met QC Criteria: July 27, 2020
• Last Verified: July 1, 2020

More Information

Terms related to this study

• Keywords: post traumatic stress disorder; traumatic memories; motor interference therapy; non pharmacological therapy; trauma related disorders
• Additional Relevant MeSH Terms: Mental Disorders; Trauma and Stressor Related Disorders; Stress Disorders, Traumatic; Stress Disorders, Post-Traumatic; Psychological Trauma
• Other Study ID Numbers: 69/17

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No