The Role of Cognitive Function and Electroencephalography on Acute and Chronic Pain After Surgery

The project will apply the methods of clinical observation experiment, (1) to collect the cognitive function data preoperatively and early postoperatively, as well as the pain score data at multiple time points pre- and postoperatively, and to observe the role of the degree of recovery of early postoperative cognitive function on acute pain and chronic pain after surgery. (2) to collect the resting-state electroencephalography (EEG) preoperatively, and to assess the role of EEG index system on the prediction of the degree of recovery of early postoperative cognitive function as well as the acute pain and chronic pain after surgery.

Study Overview

• Status: Enrolling by invitation
• Conditions: Chronic Pain; Acute Pain; Thoracic Surgery; Electroencephalography; Brain Mechanism

Detailed Description

Patients after surgery are liable to suffer from moderate to severe acute pain and refractory chronic pain, which would lead to serious somatic and psychological suffering. Its successful treatment is a great challenge for pain physicians. To date, the mechanism of pain chronification after surgery remains unclear. Further, it is still lack of efficient preventive and therapeutic measures for this chronic pain. The project will apply the methods of clinical observation and animal experiment, (1) to collect the cognitive function data preoperatively and early postoperatively, as well as the pain score data at multiple time points pre- and postoperatively, and to observe the role of the degree of recovery of early postoperative cognitive function on acute pain and chronic pain after thoracic surgery. (2) to collect the resting-state electroencephalography (EEG) preoperatively, and to assess the role of EEG index system on the prediction of the degree of recovery of early postoperative cognitive function as well as the acute pain and chronic pain after thoracic surgery. The project will be able to determine the relationships between the degree of recovery of early postoperative cognitive function, as well as preoperative resting-state EEG indices and postoperative acute pain and chronic pain, and clarify the neural mechanism of acute pain and chronic pain after surgery. The expected outcomes of this study can contribute to early identification of the patients who are liable to develop into acute pain and chronic pain after surgery, and give them reasonable intervention in time, and provide effective solutions for the acute pain and chronic pain after surgery.

• Study Type: Observational
• Enrollment (Anticipated): 100

Contacts and Locations

Study Locations

• China
  • Beijing
    • Beijing, Beijing, China, 100044
      • Peking University People's Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

100

Description

Inclusion Criteria:

• surgery were planned to be performed under general anesthesia
• Educational attainment beyond high school
• Require postoperative analgesia and sign the informed consent

Exclusion Criteria:

• with mental illness or a family history of mental illness
• Patients with cerebrovascular diseases or cerebrovascular accidents
• Previous head trauma history or craniotomy
• Using central analgesics, opioids addiction
• With a history of alcoholism
• do not understand the numerical rating scale(NRS) score and can not use patient-controlled analgesia(PCA）

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
acute pain	numerical rating scale(NRS)>3	the third day of the surgery
chronic pain	numerical rating scale(NRS)>3	the second month of the surgery

Collaborators and Investigators

• Sponsor: Yi Feng, MD

Publications and helpful links

General Publications

• Han Q, Yue L, Gao F, Zhang L, Hu L, Feng Y. The Prediction of Acute Postoperative Pain Based on Neural Oscillations Measured before the Surgery. Neural Plast. 2021 Apr 9;2021:5543974. doi: 10.1155/2021/5543974. eCollection 2021.

Study record dates

Study Major Dates

• Study Start (Actual): December 21, 2018
• Primary Completion (Actual): March 31, 2021
• Study Completion (Anticipated): October 31, 2023

Study Registration Dates

• First Submitted: November 30, 2018
• First Submitted That Met QC Criteria: November 30, 2018
• First Posted (Actual): December 3, 2018

Study Record Updates

• Last Update Posted (Actual): October 18, 2022
• Last Update Submitted That Met QC Criteria: October 15, 2022
• Last Verified: October 1, 2022

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pain; Neurologic Manifestations; Chronic Pain; Acute Pain
• Other Study ID Numbers: 2018PHB191-02

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No