- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03780816
Variation in Cancer Centers' End-of-Life Quality
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The purpose of this study is to identify organizational and provider practice norms at major US cancer centers, and how these norms influence patient and family expectations and provider decision-making heuristics for later-line chemotherapy, hospice, and ICU admission among minority patients with advanced cancer. Norms are rules about which there is at least some degree of consensus, enforced through social sanctions. Heuristics are unconscious judgments or rules of thumb.The study team will collect direct observation data from outpatient clinic visits, and semi-structured interview data from selected participating providers, patients, caregivers, and other informants following the initial observation.
The study team will perform 2-week, qualitative case studies of 3 theoretically sampled National Comprehensive Cancer Network (NCCN) and NCI Comprehensive Cancer Centers. Oncology practice managers' nominations of providers with particular cancer focuses, high volumes, and high peer influence will be used to sample oncologic clinicians to shadow in outpatient clinic settings. Observations will be hand-written during the clinic visit, and later dictated and transcribed. Observed providers will be invited to be interviewed. Select patients and caregivers will also be invited to be interviewed following initial clinic observation. Other informants will be invited to be interviewed on an ad hoc basis. All interviews will be audio recorded and transcribed, and interviews will be semi-structured to allow for natural flow of conversation. Observations and interviews will all be done by the study PI, project coordinator, and/or another research team member.
Clinical observations and semi-structured interviews will assess the following outcomes: 1) formal and informal organizational norms influencing provider decision-making, 2) provider decision-making heuristics, and 3) patient and caregiver expectations. All outcomes will be assessed regarding receipt of chemotherapy in the last 14 days of life, intensive care unit (ICU) admission in the last 30 days of life, and non or late hospice referral.
The investigators aim to to explore the how COVID-19 intersects with organizational and provider norms, practices, and service delivery for patients with advanced cancer.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
New Hampshire
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Lebanon, New Hampshire, United States, 03766
- Dartmouth Hitchcock Medical Center
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Outpatient and inpatient oncology providers who meet inclusion criteria and are nominated by their practice managers will be observed. If providers do not opt out after being introduced to the study by cancer center leadership, providers will be contacted directly for recruitment. A sub-sample of observed providers will be invited to participate in semi-structured interviews.
A sub-sample of all patients (and caregivers) cared for by the shadowed provider who meet inclusion criteria will be invited to participate in semi-structured interviews. Recruitment will seek equal numbers of minority and non-minority participants.
Personnel involved in developing and enforcing organizational policies, procedures, and practices, will also be invited to participate in semi-structured interviews.
Description
Provider Inclusion Criteria:
- Hospital-based providers (e.g., hospitalists, intensivists, emergency medicine, advanced practice providers) or oncology providers (e.g. medical oncologists, radiation oncologists, surgical oncologists, advanced practice providers)
- Care for patients with advanced cancer
- High clinical load
- Have high peer influence
Patient Inclusion Criteria:
- Advanced cancer
- Provider "would not be surprised" if patient died in the next 12 months
Caregiver Inclusion Criteria:
-Self-reported caregiver of a patient meeting inclusion criteria
Other Informant Inclusion Criteria:
- Member of the cancer center, hospital, unit, or service line leadership
Patient Exclusion Criteria:
- Potential medical malpractice cases
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Pilot Site: Norris Cotton Cancer Center
Observation and interview protocols will be piloted at this site.
The content of these observations and interviews will not be analyzed for content.
|
Clinical interactions between cancer patients and providers will be observed and hand-written field notes recorded and later transcribed.
Semi-structured interviews with providers, patients, caregivers, and other informants will take place following initial observation.
|
Karmanos Cancer Institute
Observations and interviews will be analyzed to identify any emergent concepts, categories, and relationships in the data.
|
Clinical interactions between cancer patients and providers will be observed and hand-written field notes recorded and later transcribed.
Semi-structured interviews with providers, patients, caregivers, and other informants will take place following initial observation.
|
UNC Lineberger Comprehensive Cancer Center
Observations and interviews will be analyzed to identify any emergent concepts, categories, and relationships in the data.
|
Clinical interactions between cancer patients and providers will be observed and hand-written field notes recorded and later transcribed.
Semi-structured interviews with providers, patients, caregivers, and other informants will take place following initial observation.
|
UAB O'Neal Comprehensive Cancer Center
Observations and interviews will be analyzed to identify any emergent concepts, categories, and relationships in the data.
|
Clinical interactions between cancer patients and providers will be observed and hand-written field notes recorded and later transcribed.
Semi-structured interviews with providers, patients, caregivers, and other informants will take place following initial observation.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Formal and informal norms influencing provider decision making as assessed using ethnographic observation
Time Frame: 2-week site observation period
|
Formal and informal norms influencing provider decision making (regarding receipt of chemotherapy in the last 14 days of life, intensive care unit (ICU) admission in the last 30 days of life, and non or late hospice referral) will be assessed using ethnographic observation in outpatient oncology clinics, multidisciplinary tumor boards, emergency departments, inpatient units, and other appropriate settings.
All observations will be hand-written and later transcribed.
Observations will be coded using an a priori framework, and subjected to thematic analysis.
|
2-week site observation period
|
Provider decision making heuristics as assessed using ethnographic observation
Time Frame: 2-week site observation period
|
Provider decision making heuristics (regarding receipt of chemotherapy in the last 14 days of life, intensive care unit (ICU) admission in the last 30 days of life, and non or late hospice referral) will be assessed using ethnographic observation in outpatient oncology clinics, multidisciplinary tumor boards, emergency departments, inpatient units, and other appropriate settings.
All observations will be hand-written and later transcribed.
Observations will be coded using an a priori framework, and subjected to thematic analysis.
|
2-week site observation period
|
Patient expectations as assessed using ethnographic observation
Time Frame: 2-week site observation period
|
Patient expectations (regarding receipt of chemotherapy in the last 14 days of life, intensive care unit (ICU) admission in the last 30 days of life, and non or late hospice referral) will be assessed using ethnographic observation in outpatient oncology clinics, emergency departments, inpatient units, and other appropriate settings.
All observations will be hand-written and later transcribed.
Observations will be coded using an a priori framework, and subjected to thematic analysis.
|
2-week site observation period
|
Formal and informal norms influencing provider decision making as assessed using semi-structured interviews
Time Frame: 2-week site observation period
|
Formal and informal norms influencing provider decision making (regarding receipt of chemotherapy in the last 14 days of life, intensive care unit (ICU) admission in the last 30 days of life, and non or late hospice referral) will be assessed using a study-specific semi-structured interview, with all interviews audio recorded and transcribed, coded using an a priori framework, and subjected to thematic analysis.
|
2-week site observation period
|
Provider decision making heuristics as assessed using semi-structured interviews
Time Frame: 2-week site observation period
|
Provider decision making heuristics (regarding receipt of chemotherapy in the last 14 days of life, intensive care unit (ICU) admission in the last 30 days of life, and non or late hospice referral) will be assessed using a study-specific semi-structured interview, with all interviews audio recorded and transcribed, coded using an a priori framework, and subjected to thematic analysis.
|
2-week site observation period
|
Patient expectations as assessed using semi-structured interviews
Time Frame: 2-week site observation period
|
Patient expectations (regarding receipt of chemotherapy in the last 14 days of life, intensive care unit (ICU) admission in the last 30 days of life, and non or late hospice referral) will be assessed using a study-specific semi-structured interview, with all interviews audio recorded and transcribed, coded using an a priori framework, and subjected to thematic analysis.
|
2-week site observation period
|
Collaborators and Investigators
Collaborators
Investigators
- Principal Investigator: Amber E Barnato, MD, Dartmouth-Hitchcock Medical Center
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- D18149
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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