The Effect of Aronia Melanocarpa Extract on Cognitive Function

The Effect of Short-term Aronia Melanocarpa Extract Supplementation on Cognitive Function in Healthy Young Adults

There is a great interest in improving cognitive performance, including memory and attention. Improved attention is desirable for a large group of people because it is linked to improved performance . Students and professionals can benefit from improved attention and thus performance in academic and other work environments. In addition, cognitive functioning also plays an important role in sports. Various cognitive skills, including attention, reaction time and motor function, have shown that they can influence sport performance. A completely natural supplement with aronia melanocarpa extract could be a promising way to naturally improve cognitive performance.

Study Overview

• Status: Completed
• Conditions: Cognitive Function
• Intervention / Treatment: Dietary supplement: Placebo; Dietary supplement: Aronia

Detailed Description

There is a great interest in improving cognitive performance, including memory and attention. Improved attention is desirable for a large group of people because it is linked to improved performance. Students and professionals can benefit from improved attention and thus performance in academic and other work environments. In addition, cognitive functioning also plays an important role in sports. Various cognitive skills, including attention, reaction time and motor function, have shown that they can influence sport performance. A completely natural supplement with aronia melanocarpa extract could be a promising way to naturally improve cognitive performance. The product in this study is aronia melanocarpa which contains polyphenols. A limited number of clinical studies have already been carried out to see the effect of similar products on cognitive functioning. However, these studies have often been done in older study populations or over a longer period of time. In this study, in healthy adolescents (ages between the 18-35 and with a BMI between 18.5 and 30), the investigators want to test the short term (7 days) effect of aronia melanocarpa extract on cognitive functioning. The investigators will also test the effect of supplementation on the particpant's mood, vascular function, blood biomarkers, retinal vasculature, and subjective cognition.

• Study Type: Interventional
• Enrollment (Actual): 36
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Netherlands
  • Limburg
    • Maastricht, Limburg, Netherlands, 6229ET
      • Maastricht University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 14 years to 31 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Healthy young adults: ages between 18 and 35
• BM between 18.5-30 kg/m2

Exclusion Criteria:

• Current use of (antioxidant) dietary supplements and not willing to quit for the duration of the study duration
• Pre-existing or history of neurological illness
• High blood pressure (>140 systolic and/or >90 diastolic mmHg)
• Use of medication that might have influence on endpoints (e.g. antidepressant)
• Known pregnancy or lactation
• Food allergy to the study product
• Administration of investigational drugs or participation in any scientific intervention study which may interfere with this study, to be decided by the principle investigator, in the 180 days prior to the study
• Abuse of products (> 20 alcoholic consumptions per week and drug usage)
• Participation in a scientific intervention study which may interfere with this study in the 180 days prior to this study

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Triple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: placebo; microcrystalline cellulose supplementation	Dietary supplement: Placebo; daily supplementation
Experimental: Aronia; aronia melanocarpa supplementation	Dietary supplement: Aronia; daily supplementation

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Cognitive function	CANTAB	After 7 days of supplementation

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Mood	VAMS	After 7 days of supplementation
Biomarkers in blood and saliva	BDNF & cortisol	After 7 days of supplementation
Vascular function	SBP & DBP, PWA & PWV	After 7 days of supplementation
Microvasculature	Fundus photography	After 7 days of supplementation
Subjective cognition	Cognitive Failures Questionnaire	After 7 days of supplementation

Collaborators and Investigators

• Sponsor: Maastricht University Medical Center
• Collaborators: BioActor B.V.
• Investigators: Principal Investigator: Jogchum Plat, Prof, Maastricht University

Study record dates

Study Major Dates

• Study Start (Actual): October 9, 2020
• Primary Completion (Actual): April 29, 2021
• Study Completion (Actual): April 29, 2021

Study Registration Dates

• First Submitted: December 19, 2018
• First Submitted That Met QC Criteria: January 2, 2019
• First Posted (Actual): January 4, 2019

Study Record Updates

• Last Update Posted (Actual): September 5, 2021
• Last Update Submitted That Met QC Criteria: September 3, 2021
• Last Verified: September 1, 2020

More Information

Terms related to this study

• Keywords: cognitive function; cognition; supplementation; vascular function; microvasculature
• Other Study ID Numbers: Brainport_002

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No