- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03813342
Retraining the Walking Pattern After Stroke
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Stroke often results in functional gait deficits and abnormal gait patterns. Typically, several features of gait are altered (e.g. knee joint movement decreases and step lengths are asymmetric). Data show that walking patterns after neurologic injury can be changed through gait training, but traditional rehabilitation approaches typically focus on changing one feature of gait at a time. However, the investigators have recently shown that in a single session individuals post-stroke are able to learn to change multiple components of this impaired gait pattern at the same time.
To further leverage this ability to learn multiple things at once, the investigators have also studied how different forms of visual feedback about leg movements may best facilitate individuals to make meaningful changes to multiple features of the gait pattern. Specifically, they have studied two forms of visual feedback - 1) multidimensional, with multiple streams of information about leg movements, and 2) one-dimensional, which distills/summarizes multiple pieces of information about the gait pattern into a single source of feedback. They have shown that the one-dimensional summary feedback is more effective to help people learn a new gait pattern that requires changing multiple features of how they are walking. This work has focused on single training sessions in neurologically intact individuals, but the authors would like to study the effects of longer-term training with these different forms of feedback. Therefore, the purpose of this study is to gather preliminary data to inform the design of a clinical trial of gait training to treat walking deficits post-stroke. The investigators will gather data to determine whether training with different forms of visual feedback about leg movements are effective at improving gait patterns post-stroke - and which form of feedback may be more effective.
The investigators will study adults with cerebral damage due to stroke. Subjects with hemiparesis will undergo training 3 times a week for a total of 12 training session. These 12 sessions will be broken into 2 blocks of 6 sessions, with at least a 2 week break in between. In each block, training will occur with one form of visual (multi- or one-dimensional). Participants will complete training with both forms of feedback, the order of feedback forms will be randomly assigned. These studies will provide important new information about gait training with visual feedback in individuals post-stroke. This study is critical for developing procedural reliability processes, calculating effect sizes, and determining other salient clinical variables in preparation for a randomized clinical trial.
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Maryland
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Baltimore, Maryland, United States, 21205
- Recruiting
- Motion Analysis Lab in the Kennedy Krieger Institute
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- stroke or hemiparesis (>6 months post stroke)
- able to walk but has a residual gait deficit (including those who walk with a cane or walker)
- Able to walk for 5 minutes at their self-paced speed
- Adults age 20-80
Exclusion Criteria:
- Cerebellar signs (e.g.ataxic hemiparesis)
- Any neurologic condition other than stroke
- Uncontrolled diabetes
- Congestive heart failure
- Peripheral artery disease with claudication
- Pulmonary or renal failure
- Unstable angina
- Uncontrolled hypertension (>190/110 mmHg)
- MoCA (Montreal Cognitive Assessment Test for Dementia) < 23
- Severe aphasia
- Orthopedic or pain conditions that limit walking
- Pregnancy
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Multichannel Visual Feedback
Gait training with visual feedback of joint kinematics.
The visual feedback will contain information about the lower limb joint angles.
We will instruct subjects to use the feedback to reach a target walking pattern.
In this arm, subjects will receive 4 channels of visual information, each of which represents a joint angle (right and left hips, right and left knees).
|
Gait training will be accomplished using a Woodway treadmill.
The visual feedback will contain information about the real-time lower-limb joint angles.
We will instruct participants to use the feedback to reach a target walking pattern.
|
Experimental: Single Channel Visual Feedback
Gait training with visual feedback of joint kinematics.
The visual feedback will contain information about the lower limb joint angles.
We will instruct subjects to use the feedback to reach a target walking pattern.
In this arm, subjects will receive 1 channel of visual information that encompasses information from 4 lower limb joint angles (right and left hips, right and left knees).
|
Gait training will be accomplished using a Woodway treadmill.
The visual feedback will contain information about the real-time lower-limb joint angles.
We will instruct participants to use the feedback to reach a target walking pattern.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
1. Change in hip and knee joint movements while walking
Time Frame: Assessed before and after the gait training provided in each Arm of the study to assess a change following each intervention. This measure will be collected during the first and last sessions of Arms 1 and 2, occurring within two weeks for each Arm.
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How closely the hip and knee movements in participants post-stroke match those of a healthy gait patter.
To collect this measure, subjects will wear special markers on their feet and body to record how their legs are moving while they walk on the treadmill.
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Assessed before and after the gait training provided in each Arm of the study to assess a change following each intervention. This measure will be collected during the first and last sessions of Arms 1 and 2, occurring within two weeks for each Arm.
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
1. Change in walking speed
Time Frame: Assessed before and after the gait training provided in each Arm of the study to assess a change following each intervention. This measure will be collected during the first and last sessions of Arms 1 and 2, occurring within two weeks for each Arm.
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Subjects will complete clinical tests of walking speed by walking overground at two paces - their normal comfortable pace and as fast as safely possible.
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Assessed before and after the gait training provided in each Arm of the study to assess a change following each intervention. This measure will be collected during the first and last sessions of Arms 1 and 2, occurring within two weeks for each Arm.
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2. Change in subjective assessment of balance confidence
Time Frame: Assessed before and after the gait training provided in each Arm of the study to assess a change following each intervention. This measure will be collected during the first and last sessions of Arms 1 and 2, occurring within two weeks for each Arm.
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Subjects will complete the 16-item Activities-Specific Balance Confidence Scale.
This is a self-report measure in which they rate their confidence that they would not lose their balance while performing specific daily activities.
Scores can range from 0 - 100, with 0 indicating the respondent has no confidence in their balance and 100 indicating that they are full confident that they can perform all items without a loss of balance.
As such, higher values represent a better outcome.
There are no sub-scales for this measure.
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Assessed before and after the gait training provided in each Arm of the study to assess a change following each intervention. This measure will be collected during the first and last sessions of Arms 1 and 2, occurring within two weeks for each Arm.
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- IRB00097573
- 2R37NS090610 (U.S. NIH Grant/Contract)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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