Oral Peri-operative TIming of Metformin (or) Salsalate to Improve Non-cardiac Surgery Glucose Control (OPTIM(i)SING)

January 12, 2023 updated by: McMaster University

Oral Peri-operative TIming of Metformin (or) Salsalate to Improve Non-cardiac Surgery Glucose Control - A Placebo-Controlled Internal Feasibility Trial

Hypothesis: In surgical patients with type 2 diabetes, taking either metformin or salsalate on the morning of surgery will reduce the incidence of hyperglycemia, inflammation and even surgical site infections, without any obvious patient risk relative to patients given a placebo control.

Anesthesia and surgery induce a number of metabolic disturbances, particularly among patients with type 2 diabetes (T2D). This includes altered glucose metabolism and hyperglycemia, which is associated with significant morbidity and mortality, including an increase in surgical site infections (SSI). Although insulin protocols can reduce blood glucose levels in hyperglycemic surgical patients, leading to reduced SSI, this has caused severe hypoglycemia in a number of patients. Instead, the use of simple and effective interventions, such as continuing metformin on the day of surgery, could represent an important step toward reducing the incidence of these morbid outcomes while improving glucose control. Alternatively, salsalate, a non-acetylated dimer of salicylic acid, has also emerged as a novel glucose-lowering medication that also possesses important anti-pyretic and anti-inflammatory properties and could prove equally effective.These refinements may also reduce SSI and inflammation. If the proposed pilot trial, to continue metformin, or take salsalate, peri-operatively, is as safe and easy as the investigators anticipate it will allow for the planning of a future definitive randomized clinical trial. The aims of this pilot trial are to assess the feasibility of safely continuing metformin, or taking salsalate on the day of surgery, with the goal of reducing the incidence of hyperglycemic events. This includes assessing our ability to recruit patients, adhere to the proposed study protocol, assess workload,and measure the desired outcomes, all of which are crucial for the planning of a subsequent clinical trial.

Study Overview

Status

Withdrawn

Conditions

Intervention / Treatment

Detailed Description

This internal pilot study (n=36) is designed as a 3-arm, parallel, placebo-controlled trial with block randomization. All parties will be blinded.

Patient Recruitment: Patients with T2D on metformin presenting to the Hamilton Health Sciences (HHS) preoperative clinic for elective surgery requiring general anesthetic will be screened for eligibility.

Sample Size: 36 patients over the 1-year study. This sample size will allow for 3 groups of 12, which permits block randomization and precise confidence interval (CI) calculations.

Randomization and Allocation: Patients will be randomized on the day of their pre-operative assessment by our department statistician using a computer-generated table, with an allocation ratio of 1:1:1 in random permuted blocks of 3 or 6. Only the pharmacist and statistician will know the allocation sequence. Concealed medications (over-encapsulated) will be provided to the RC upon confirming the allotment with a unique identification number (UIN), recorded on the patient-specific case record form (CRF).

Application of Intervention: Our intervention involves self-administered metformin (patient's usual dose) vs. salsalate (1.5g) vs. placebo with sips of water 2h prior to surgery. Baseline data (age, height, weight, ASA score, mean arterial BP, and baseline glucose) will be collected by the RC in the pre-operative assessment area, and flash glucose sensors (FreeStyle Libre, Abbot) will be placed on the upper arm as per manufacturer's instructions and readings collected by the RC. Study data will be securely stored in the anesthesia research office, McMaster University. Standard monitors will be used in the operating room, with any additional monitoring left to the anesthesiologist's discretion. Although most anesthetics appear to modify glucose metabolism, general anesthesia will be provided in their preferred manner (including dexamethasone administration for post-operative nausea and vomiting prophylaxis) to improve generalizability. Details of the type of drugs, fluids and blood loss will be recorded. Following surgery, patients will be brought to the PACU for routine monitoring (30-60 min), and additional blood samples will be drawn. Subsequent samples will be collected on the evening of surgery (6-12h) and POD1. Any episodes of hyper- or hypoglycemia will be managed routinely at the treating physician's discretion and details recorded.

Measurements of Inflammation: Blood and urine samples will be collected on the morning of surgery, upon admission to PACU, and will coincide with other tests to minimize needle sticks. Blood samples will be processed at the HHS Core Research Laboratory and divided into 3 serum and 2 EDTA aliquots, barcoded and stored in liquid nitrogen. Urine samples will be divided into 2 barcoded aliquots and stored in liquid nitrogen. This will allow for future analysis and characterization of biochemical pathways related to the surgical stress response. These future analyses will include measurement of insulin and proinsulin since salsalate may modify their endogenous metabolism. Similarly, the investigators eventually plan to measure various inflammatory markers implicated in the development of acute stress-induced insulin resistance (i.e. IL-6, TNFα, and hsCRP), which could provide insight into potential beneficial effects of salsalate or metformin.

Feasibility Outcomes: The primary feasibility outcomes include calculating the recruitment rate (both the percentage of individuals who were approached in the pre-operative clinic that enrolled in the study, and the total number of individuals that were recruited each month (Table 1, supplemental document). The ability to follow study protocol will be reported as the percentage of individuals who were able to complete the study protocol as a fraction of the total number of individuals recruited for i) drug administration and blinding, ii) blood sampling at specified times, and iii) reliability of CGM by comparison with laboratory glucose values. Workload will be calculated per patient, and safety profile assessed by recording adverse events. Together, this may identify pitfalls requiring modification prior to a full RCT.

Statistical Analysis and Feasibility: Reporting and analysis will conform to the CONSORT pilot and feasibility trials guidelines (www.consort-statement.org). Data will be collected using an encrypted online tool (RedCap, Research Electronic Data Capture) hosted at McMaster. To be feasible and continue onto a subsequent RCT the investigators will need to recruit at least 3 patients per month. Additionally, the investigators seek an adherence rate of 88.9% (32/36) to receive study drug, collect more than 90.3% (130/144) of pre-specified blood samples, and ensure 83.3% (30/36) patients have been followed up within 6 weeks of their procedure to document any complications (e.g. SSI). If targets prove difficult, then our protocol will be reevaluated for possible amendments that will not compromise final outcomes. Given this is a pilot, CIs will be calculated for outcomes of interest: rates of hyperglycemia, SSI, and degree of inflammation.

Trial Management: This pilot trial will be conducted at HHS. The trial will enlist support and collaboration from surgeons and fellow anesthesiologists. Study data will be securely stored at the anesthesia research office, McMaster University. An RC will be employed for patient recruitment and data collection. The CRFs for study patients will be randomly cross-checked for completeness and accuracy. All reports of incorrect randomizations, protocol violations or incomplete data will be noted.

Risk Assessment: This trial does not entail any higher risk to the patient than the present standard of care. It is pragmatic, and uses clinically acceptable doses with a safe profile.

Study Type

Interventional

Phase

  • Phase 1

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 75 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Elective surgical patients requiring a general anesthetic at HHS requiring at least an overnight admission;
  • Using metformin regularly for control of T2D;
  • American Society of Anesthesiologists (ASA) physical classification I, II and III;
  • Less than 1000 mL of blood loss is expected.

Exclusion Criteria:

  • Procedures for which non-steroidal anti-inflammatory drugs are contraindicated;
  • Diagnosis of renal failure (estimated glomerular filtration rate <60 mL/min/1.73m2);
  • Liver failure;
  • Previous episodes of congestive heart failure;
  • Severe hypoglycemia in the past year;
  • Conditions masking hypoglycemia (e.g. autonomic neuropathy);
  • Low random blood glucose during pre-screening (≤4.0 mmol/L);
  • Received contrast within 48h prior to, or during, surgery.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Prevention
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Quadruple

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Metformin
Self-administered metformin (patient's usual dose) taken 2 hours prior to surgery
Drug: Metformin
Metformin (usual dose) administered 2 h before surgery
Experimental: Salsalate
Self-administered salsalate taken 2 hours prior to surgery
Drug: Salsalate
Salsalate 1.5 g administered 2 h before surgery
No Intervention: Placebo
Self-administered placebo taken 2 hours prior to surgery

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Feasibility: recruitment rate (percentage)
Time Frame: One year
Percentage (%) of individuals who were approached in the pre-operative clinic that enrolled in the study
One year
Participants with hyperglycemia
Time Frame: One year
Detect change in hyperglycemic events (glucose >11mmol/L) at the 4 blood sampling time points for each participant
One year
Feasibility: recruitment rate (total number per month)
Time Frame: One year
Number (n) of individuals recruited each month
One year

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Blood glucose levels (glycemic control)
Time Frame: One year
Evaluation of glycemic control by calculating mean blood glucose levels obtained at 4 time points
One year
Number of participants with inflammation
Time Frame: One year
Measured using validated biomarkers (IL-6, tumor necrosis factor, high-sensitivity C reactive protein), and surgical site infections recorded within 6 weeks of surgery
One year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

McMaster University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Anticipated)

December 1, 2023

Primary Completion (Anticipated)

June 1, 2024

Study Completion (Anticipated)

December 1, 2024

Study Registration Dates

First Submitted

January 18, 2019

First Submitted That Met QC Criteria

January 23, 2019

First Posted (Actual)

January 25, 2019

Study Record Updates

Last Update Posted (Estimate)

January 13, 2023

Last Update Submitted That Met QC Criteria

January 12, 2023

Last Verified

January 1, 2023

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 5451

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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