Changes in Elastic Properties of Descending Thoracic Aorta After Ascending Aorta Replacement

January 24, 2019 updated by: MORGANT Marie-Catherine, Centre Hospitalier La Chartreuse

Impact of Ascending Aorta Replacement by Graft on Elastic Properties of Descending Thoracic Aorta Evaluated by Cardiac Magnetic Resonance Imaging

The aim of our study was to evaluate the impact of aortic root replacement by a graft on the elastic properties of the descending thoracic aorta using cardiac Magnetic Resonance Imaging (MRI) and automatic post-processing.

Nineteen patients were operated on an aortic root aneurysm and a cardiac MRI allowing aortic compliance measurement was performed before and after surgery. Images were acquired with a 1.5 T MRI with only one additional sequence to a conventional aortic MRI protocol.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Observational and retrospective trial on medical data only. The patients are operated of planned aortic root aneurysm without additional intervention.

The pre and postoperative cardiac MRI are planned in standard of care.

Study Type

Observational

Enrollment (Actual)

19

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 99 years (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

19 patients operated in Cardiac Surgery unit of DIJON Hospital between September 2014 and December 2017.

Description

Inclusion Criteria:

  • > 18 years
  • Elective patient
  • Ascending aorta replacement with graft

Exclusion Criteria:

  • Prior cardiac surgery
  • Contraindication to performing cardiac MRI

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Retrospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Aortic compliance of descending aorta (mm2/mmHg)
Time Frame: post-operative cardiac MRI performing between 12 and 24 months

Aortic elastic properties of the descending aorta before and after aortic root replacement using cardiac MRI.

Aortic compliance is a local measurement of elastic properties which is obtained with cardiac MRI images by computer processing.
post-operative cardiac MRI performing between 12 and 24 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Aortic compliance of ascending aorta (mm2/mmHg)
Time Frame: post-operative cardiac MRI performing between 12 and 24 months

Aortic elastic properties of the ascending aorta before and after aortic root replacement using cardiac MRI.

Aortic compliance is a local measurement of elastic properties which is obtained with cardiac MRI images by computer processing.
post-operative cardiac MRI performing between 12 and 24 months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Hospitalier La Chartreuse

Collaborators

JAZAYERI Aline
BOUCHOT Olivier
JAZAYERI Saed
MALAPERT Ghislain
PETROSYAN Andreanik

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

September 1, 2014

Primary Completion (Actual)

January 17, 2019

Study Completion (Actual)

January 17, 2019

Study Registration Dates

First Submitted

January 17, 2019

First Submitted That Met QC Criteria

January 24, 2019

First Posted (Actual)

January 25, 2019

Study Record Updates

Last Update Posted (Actual)

January 25, 2019

Last Update Submitted That Met QC Criteria

January 24, 2019

Last Verified

January 1, 2019

More Information

Terms related to this study

Other Study ID Numbers

  • MORGANT 2019

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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