Effects of Sodium Bicarbonate Supplementation on Intermittent and Intense Task

Sodium Bicarbonate Supplementation Promotes Changes in Performance, Muscle Activity and Strength of Individuals Trained During the Performance of Intermittent and Intense Task? Randomized, Double-blind, Crossover Trial

The aim of this study was to verify if sodium bicarbonate (NaHCO3) suplementation promotes changes in the performance, muscular activity and strength of individuals trained during the intermittent and intense task . Twelve trained adult men will participate in this randomized, double-blind, crossover clinical trial. Each participant should receive two types of intervention with a 14-day interval between conditions: alkalosis (ALK) in which gelatinous capsules containing 0.3 g.kg -1 of NaHCO 3 and placebo (PLA) are administered, in which 0.3 g.kg-1 of Calcium Carbonate (CaCO3). The following results will be considered: electromyographic activity (EMG) of the quadriceps muscle, peak torque, pH, lactate, and perception of effort, recovery and pain questionnaires, which will be collected during intermittent and high intensity DI protocol. ANOVA of repeated measures will be used to verify possible differences between groups.

Study Overview

• Status: Unknown
• Conditions: Fatigue; Electromyography; Sodium Bicarbonate; Alkalosis, Metabolic
• Intervention / Treatment: Dietary supplement: Sodium bicarbonate; Dietary supplement: Calcium carbonate

• Study Type: Interventional
• Enrollment (Anticipated): 12
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Brazil
  • São Paulo, Brazil, 06454050
    • Nove de Julho University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 16 years to 38 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• resistance trained men (minimum 12 moths resistance training experience)

Exclusion Criteria:

• diabetes mellitus;
• respiratory (asthma, COPD), renal, metabolic, rheumatic and cardiovascular disorders;
• acid-base balance disorder;
• continuous use of some type of medication;
• use of high-protein supplementation and creatine supplementation;
• users of anabolic steroids.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Quadruple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Alkalosis group; The subjects should receive gelatinous capsules containing 0.3 g.kg -1 of sodium bicarbonate	Dietary supplement: Sodium bicarbonate; The subjects should ingest 0.3g.kg of sodium bicarbonate 90 minutes before the beginning of the protocol task.
Placebo Comparator: Placebo group; The subjects should receive gelatinous capsules containing 0.3 g.kg -1 of Calcium Carbonate	Dietary supplement: Calcium carbonate; The subjects should receive gelatinous capsules containing 0.3 g.kg -1 of Calcium Carbonate

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Electromyographic activity of the femoral quadriceps evaluated with electromyography equipment	The electromyographic activity will be obtained during the execution of 10 series composed of ten repetitions of extension (concentric phase) and flexion (eccentric phase) of the knee joint, at an angular velocity of 120os-1 (radians per second), with interval of 1 minute interval between sets in an isokinetic dynamometer.	60 minutes
Peak torque assessed with isokinetic dynamometer equipment	The peak torque will be obtained during the execution of 10 series composed of ten repetitions of extension (concentric phase) and flexion (eccentric phase) of the knee joint, at an angular velocity of 120os-1 (radians per second), with interval of 1 minute interval between sets.	60 minutes

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Lactate assessed with portable lactometer	The lactate quantification will be performed before and after the test session characterized by the execution of 10 series composed of ten repetitions of extension (concentric phase) and flexion (eccentric phase) of the knee joint, at an angular velocity of 120os-1 (radians per second), with an interval of 1 minute between sets in an isokinetic dynamometer.	15 seconds

Collaborators and Investigators

• Sponsor: University of Nove de Julho
• Collaborators: Marcelo Martins Kalytczak

Study record dates

Study Major Dates

• Study Start (Anticipated): October 20, 2019
• Primary Completion (Anticipated): October 30, 2019
• Study Completion (Anticipated): November 30, 2019

Study Registration Dates

• First Submitted: February 6, 2019
• First Submitted That Met QC Criteria: February 8, 2019
• First Posted (Actual): February 12, 2019

Study Record Updates

• Last Update Posted (Actual): October 17, 2019
• Last Update Submitted That Met QC Criteria: October 16, 2019
• Last Verified: October 1, 2019

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Metabolic Diseases; Acid-Base Imbalance; Alkalosis; Physiological Effects of Drugs; Molecular Mechanisms of Pharmacological Action; Gastrointestinal Agents; Calcium-Regulating Hormones and Agents; Antacids; Calcium; Calcium Carbonate
• Other Study ID Numbers: FP001

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: Undecided

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No