Source Monitoring Déficit in Neuropsychiatric Population

the investigators will measure source-monitoring ability in patients with several neuropsychiatric condition and in healthy controls appaired in age, sex and educational level. Source-monitoring will be measured thanks to internal- and reality-monitoring informatic tasks.The investigators hypothesized patients with fronto-temporal abnormalities would show more marked deficits than patients with only frontal abnormalities.

Study Overview

• Status: Recruiting
• Conditions: Psychiatric Disorder
• Intervention / Treatment: Other: Monitoring source test

Detailed Description

Source-monitoring abilities will be measured thanks to reality-monitoring testing (i.e. the ability to distinguish internal-generated events from external ones) and internal-monitoring testing (i.e. the ability to distinguish an imagined source from a performed one). A source-monitoring deficit have been demonstrated in patients with psychiatric conditions such as schizophrenia and seems linked to frontotemporal abnormalities (frontotemporal dysconnectivity and temporal hypoactivity). With a total of 150 patients, the investigators will include 30 patients per group: patients with pre-dementia stage Alzheimer, Alzheimer, Fronto-Temporal dementia, Lewy Body dementia or Parkinson and Bipolar Disorder, with the hypothesis that Bipolar Disorder patients will present less marked deficit. The investigators will recruit 150 healthy controls.

• Study Type: Interventional
• Enrollment (Estimated): 300
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: JEROME BRUNELIN, PHD; Phone Number: 00334 37 91 55 65; Email: jerome.brunelin@ch-le-vinatier.fr
• Study Contact Backup: Name: Jean-Michel DOREY, PHD; Phone Number: 00334 37 91 52 49; Email: jean-michel.dorey@ch-le-vinatier.fr

Study Locations

• France
  • Rhône Alpes
    • Bron, Rhône Alpes, France, 69678
      • Recruiting
      • Centre Hospitalier le Vinatier
      • Contact: VIAL VERONIQUE; Phone Number: 0033437915531; Email: veronique.vial@ch-le-vinatier.fr

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Subjects who gave their free and informed consent;
• Men and women;
• Aged 18 to 80;
• Having normal or corrected vision;
• Mastering the French language (read and spoken);
• All subjects will not have a working memory deficit preventing the test from being passed (MMSE short version):AM patients should have a score of <MMSE <26; Patients with pre-dementia AD will be diagnosed according to Dubois criteria (Dubois et al., 2016); patients with early FTD will be diagnosed according to Rascovsky's criteria (Rascovsky et al., 2011); Patients with DCL will be diagnosed according to McKeith's criteria (McKeith et al., 2005), TBP patients will be diagnosed using DSM 5 criteria (Arlington VA, 2013).

Exclusion Criteria:

• Inadmissibility of the consent or refusal of the subject.
• Patients under guardianship

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Patients with with neuropsychiatric conditions; In this arm, five groups : Patients with DFT, diagnosed according Racovsky criteria; Patients with Lewi Body dementia, diagnosed according McKeith criteria; Patients with pre-demential Alzheimer, diagnosed according Dubois criteria; Patients with Alzheimer, diagnosed according MMSE; Patients with bipolar disorder, diagnosed according DSM 5	Other: Monitoring source test; Internal- and external-monitoring correct responses and inversions
Active Comparator: Healthy subjects; Healthy controls appaired in age, sex and educational level	Other: Monitoring source test; Internal- and external-monitoring correct responses and inversions

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
measure source memory performance	in patients with neuropsychiatric disorders with or without temporal involvement (pre-dementia Alzheimer's disease, Alzheimer's disease - AD, fronto-temporal dementia - DFT, Lewy body dementia - DCL and bipolar disorder - TBP) and healthy volunteers matched in age, gender, and level of education.	one year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
measure the recognition of distractors	words not presented during the source monitoring test phase but presented during the recall phase. This measure will allow us to avoid that a disturbance invading the working memory or attentional capacities does not compromise the good realization of the task.	one year

Collaborators and Investigators

• Sponsor: Hôpital le Vinatier
• Investigators: Principal Investigator: JEROME BRUNELIN, PHD, Centre Hospitalier Le Vinatier - CRNL - INSERM

Study record dates

Study Major Dates

• Study Start (Actual): March 8, 2019
• Primary Completion (Estimated): March 8, 2026
• Study Completion (Estimated): July 31, 2026

Study Registration Dates

• First Submitted: March 11, 2019
• First Submitted That Met QC Criteria: March 20, 2019
• First Posted (Actual): March 22, 2019

Study Record Updates

• Last Update Posted (Actual): July 31, 2025
• Last Update Submitted That Met QC Criteria: July 30, 2025
• Last Verified: July 1, 2025

More Information

Terms related to this study

• Keywords: Bipolar Disorder; Source-monitoring
• Additional Relevant MeSH Terms: Behavioral Symptoms; Problem Behavior; Mental Disorders
• Other Study ID Numbers: 2018-A00584-51

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No