- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03912155
Multi-scale Analysis of Physiological Brain Networks (SCALES)
Multi-scale Analysis of Physiological and Pathological Brain Networks by Simultaneous EEG-MEG-SEEG Recordings
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Brain function is based on the communication between sets of neurons at different spatial and temporal scales. The dysfunction of these networks is thus at the origin of several brain pathologies, including epilepsy. The recent improvement in recording methods paves the way for better characterization of brain networks, with several spatial and temporal resolutions, depending on the techniques used.
Still, several key points remain outstanding. First, several mechanisms can underlie the interaction between brain regions, and it remains to determine the most relevant tools in practice to quantify them. Second, there are difficulties in extracting these networks from surface recordings. The best strategies for studying these interactions in a non-invasive way therefore remain to be defined.
It will be propose to answer these questions based on simultaneous surface (magneto-encephalography/ electroencephalography) and depth (intracerebral stereotactic EEG, SEEG) recordings, a technique it was developed by the team of Marseille, in patients undergoing preoperative epilepsy assessment.
The primary objective is to find, among all the mechanisms of interaction between brain regions, which are most relevant in describing physiological and pathological brain networks.
The secondary objective is to test whether the visible coupling information at depth can be found from surface data (EEG, MEG) only. To do this, it will be compare the surface results with the SEEG results.
The SEEG implantation is performed on purely clinical criteria for preoperative diagnosis. Magnetoencephalography and EEG are purely passive techniques that do not involve any additional risk. This project is a continuation of an existing project in which we have demonstrated the feasibility of simultaneous SEEG and MEG/EEG recordings.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Fabrice Bartolomei, PU-PH
- Phone Number: +33 491384995
- Email: fabrice.bartolomei@ap-hm.fr
Study Locations
-
-
-
Marseille, France, 13354
- Recruiting
- Assistance Publique Hopitaux de Marseille
-
Contact:
- Fabrice Bartolomei, PUPH
- Phone Number: +33 491384995
- Email: fabrice.bartolomei@ap-hm.fr
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
Inclusion criteria for patients
- Patients for whom intracerebral electrode implantation is in progress as part of the pre-surgical evaluation of their drug-resistant partial epilepsy.
- Patient informed, expressing his non-opposition (or legal representative (s), affiliated to a social security scheme
- The medical examination is carried out as part of the medical follow-up of these patients
Inclusion criteria for control subjects
• Informed subject, expressing his non-opposition or legal representative, affiliated to a social security scheme
- Exclusion Criteria:
Minors under 12 years
- Pregnant or lactating women,
- The adults under guardianship or under the protection of justice
- Non-beneficiaries of a social security scheme
- Persons deprived of their liberty by a judicial or administrative decision
- Absence of informed consent
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Patients
20 patients per presumed location of the epileptogenic zone (see experimental plan) for a total of 120 patients, including 30 minors.
For patients, a MEG-EEG-SEEG examination during the SEEG exploration period.
|
It will be simultaneously record the surface EEG, the MEG and in patients only the intracerebral EEG (SEEG).
In the case of SEEG with micro contacts, these additional signals will also be recorded in parallel and will provide greater sensitivity to high frequency activities.
The physiological networks will be studied in patients thanks to stimulations (external or intracerebral) carried out within the framework of the functional cartography, and the pathological networks thanks to measures in state of rest.
For external stimulation protocols, it will be constitute a reference base in MEG and EEG alone (non-invasive) on control subjects.
|
Controles
For the control population, 120 control subjects, including 30 minors, that is to say as many as patients.
For control subjects, a MEG-EEG exam.
|
It will be simultaneously record the surface EEG, the MEG and in patients only the intracerebral EEG (SEEG).
In the case of SEEG with micro contacts, these additional signals will also be recorded in parallel and will provide greater sensitivity to high frequency activities.
The physiological networks will be studied in patients thanks to stimulations (external or intracerebral) carried out within the framework of the functional cartography, and the pathological networks thanks to measures in state of rest.
For external stimulation protocols, it will be constitute a reference base in MEG and EEG alone (non-invasive) on control subjects.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Rate of epileptic discharges
Time Frame: 2 hours
|
Measurement of epileptic activity by electroencephalogram
|
2 hours
|
Rate of epileptic discharges
Time Frame: 2 hours
|
Measurement of epileptic activity by magneto-encephalography
|
2 hours
|
Rate of epileptic discharges
Time Frame: 2 hours
|
Measurement of epileptic activity by intracerebral stereotactic electroencephalogram
|
2 hours
|
Collaborators and Investigators
Investigators
- Study Director: Jean-Olivier ARNAUD, Director, Assistance Publique Hopitaux de Marseille
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2018-51
- 2018-A02363-52 RCB (Registry Identifier: APHM)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Epilepsy
-
NaviFUS CorporationTaipei Veterans General Hospital, TaiwanCompletedDrug Resistant Epilepsy | Epilepsy, Drug Resistant | Intractable Epilepsy | Refractory Epilepsy | Drug Refractory Epilepsy | Epilepsy, Drug Refractory | Epilepsy, Intractable | Medication Resistant EpilepsyTaiwan
-
Great Ormond Street Hospital for Children NHS Foundation...Active, not recruitingEpilepsies, Partial | Intractable Epilepsy | Focal Epilepsy | Refractory Epilepsy | Epilepsy Intractable | Epilepsy in Children | Epilepsy, FocalUnited Kingdom
-
University of British ColumbiaTerminatedJuvenile Myoclonic Epilepsy | Childhood Absence Epilepsy | Juvenile Absence EpilepsyCanada
-
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityRecruiting
-
Neuroelectrics CorporationRecruitingEpilepsy | Seizures | Refractory Epilepsy | Epilepsy, Tonic-Clonic | Epilepsy in Children | Seizures, Focal | Focal SeizureSpain, United States, France, Belgium
-
Oslo University HospitalCompletedEpilepsy | Generalized Epilepsy | Focal EpilepsyNorway
-
UCB Pharma SACompletedEpilepsy, Tonic-clonicPoland, Sweden, Hungary, Czechia
-
UCB PharmaCompletedEpilepsy, Tonic-clonic
-
University Hospital, LilleUnknownFocal Epilepsy | Epilepsy IntractableFrance
-
Xuanwu Hospital, BeijingPeking University; Beijing Tiantan Hospital; Qilu Hospital of Shandong University and other collaboratorsNot yet recruitingEpilepsy, Drug ResistantChina
Clinical Trials on Multi-scale analysis of physiological brain networks
-
MDI HealthHadassah Medical OrganizationCompletedPolypharmacy PatientsIsrael
-
Qilu Hospital of Shandong UniversityNot yet recruiting
-
Fudan UniversityRecruiting
-
Istituto Clinico HumanitasRecruiting
-
Leiden University Medical CenterRecruitingUveal MelanomaNetherlands
-
Sunnybrook Health Sciences CentreMOUNT SINAI HOSPITAL; Princess Margaret Hospital, Canada; Trillium Health PartnersRecruiting
-
Beijing Friendship HospitalBeijing Shuyi HospitalRecruitingMaintenance HemodialysisChina
-
Xinhua Hospital, Shanghai Jiao Tong University...Recruiting
-
University of FloridaUniversity of South Florida; National Institute of Neurological Disorders and...CompletedSpinocerebellar AtaxiaUnited States
-
City of Hope Medical CenterNational Cancer Institute (NCI)RecruitingHematopoietic Cell Transplant Recipient | Cytomegaloviral InfectionUnited States