Uncontrolled Donation After Circulatory Determination of Death (uDCDD) (uDCDD)

Uncontrolled Donation After Circulatory Determination of Death (uDCDD): A Potential Solution to the Shortage of Organs in Quebec?

World-wide, patients waiting for organ transplantation exceed the number of organs available. Many European countries have a uDCDD program which contribute to 10-15% of the donor pool. In Canada, this type of program does not exist. The purpose of this study is to report how many deceased person fulfill the criteria for uncontrolled DCDD in a Canadian medical center.

Study Overview

• Status: Completed
• Conditions: Uncontrolled Donation After Circulatory Determination of Death

Detailed Description

While transplantation has become the definitive treatment for many people suffering end-stage organ failure, demand exceeds supply. For many years, donation after neurological death represented the principal source of organs for transplantation. In the last decade, prevention measures, improvements in neurocritical care, and decompressive craniectomy have led to a significant decrease in the number of non-directed donors (NDDs). In such situations, alternative sources for organ donation must be identified. Cardiac-arrest patients could provide a solution to this organ shortage. Patients who have experienced unexpected in or out of hospital cardiopulmonary arrest could become organ donors. Organ donation following uncontrolled cardiocirculatory death is currently practiced in many European countries. However, in Canada, it's not yet authorized. Yet, each deceased could save up to four lives. The purpose of this study is to determine the organ potential for a cohort of patient who had died from a cardiopulmonary arrest at the CHUS in 2015 and assess the effect of the implementation of a uDCD program on the number of additional donors.

• Study Type: Observational
• Enrollment (Actual): 1111

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

This study will be conducted in one organ-donation center in Quebec that is a teaching hospital and referral center for interventional cardiology. It serves a mixed urban and rural population of 350,000.

Description

Inclusion Criteria:

• All patients treated for cardiocirculatory arrest at the CIUSSS-Estrie CHUS in 2015.

Exclusion Criteria:

• Patients with a status of no resuscitation
• Pediatric patients (<18 years old)
• Adults >65 years old

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Potential contribution of a uDCDD program on the number of additional donors.	Defined as (must meet all criteria): Age ≤70 years old; Absence of obvious cause of death (rigor mortis, decapitation, overwhelming traumatic injury); Absence of surgical cause of cardiac arrest; No sign of IV drug abuse; No history of malignancies	1 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Effect of the implementation of a uDCDD program on the number of additional organs suitable for transplantation.	Effect of the implementation of a uDCDD program on the number of additional organs suitable for transplantation.	1 year
Number of tissus donors	Number of tissus donors	1 year
Potential obstacles and solutions related to the implementation of a uDCDD program in Canada.	Potential obstacles and solutions related to the implementation of a uDCDD program in Canada.	1 year
Areas of future research.	Areas of future research.	1 year

Collaborators and Investigators

• Sponsor: Université de Sherbrooke
• Investigators: Principal Investigator: Frédérick D'Aragon, Dr/Pr, Université de Sherbrooke

Study record dates

Study Major Dates

• Study Start (ACTUAL): May 1, 2016
• Primary Completion (ACTUAL): August 1, 2016
• Study Completion (ACTUAL): August 1, 2016

Study Registration Dates

• First Submitted: April 16, 2019
• First Submitted That Met QC Criteria: April 29, 2019
• First Posted (ACTUAL): May 2, 2019

Study Record Updates

• Last Update Posted (ACTUAL): May 2, 2019
• Last Update Submitted That Met QC Criteria: April 29, 2019
• Last Verified: June 1, 2016

More Information

Terms related to this study

• Keywords: unexpected cardiopulmonary arrest; potential organ donors
• Additional Relevant MeSH Terms: Pathologic Processes; Death
• Other Study ID Numbers: 2016-1416

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO