Incidence, Risk Factors, Predictors and Survival for Neurological Complications After Liver Transplantation

Incidence, Risk Factors, Predictors and Survival for Neurological Complications After Liver Transplantation- A Retrospective Analysis

Liver transplantation is the definitive treatment in patients with chronic liver disease. Neurological complications (NC) occur commonly after liver transplantation. The investigators aim to evaluate the incidence, risk factors and predictors of neurological complications in both living donor and deceased donor transplantation done in the hospital. Between January 2011 to December 2016, 253 liver transplant recipients were recruited for this study. The investigators recorded the incidence of neurological complications, their median time of onset, their relationship with etiology of chronic liver disease, and the risk factors for the complications. The investigators also studied the relationship of neurological complications with duration of hospital and ICU stay, and survival. Using multivariate forward regression analysis , the investigators developed a scoring system for prediction of neurological complications in liver transplantation.

Study Overview

• Status: Completed
• Conditions: Postoperative Complications; Liver Transplant; Complications; Neurologic Complication

• Study Type: Observational
• Enrollment (Actual): 253

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

All patients who underwent liver transplant surgery for the specified time period were included in the study.

Description

Inclusion Criteria:

• patients undergoing liver transplant surgery
• 18-65 years

Exclusion Criteria:

• pregnant patients
• Acute Liver Failure, Acute on Chronic Liver Failure

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Retrospective

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Neurological complications	type of neurological complication	90 days
Mortality	mortality due to any cause	90 days

Collaborators and Investigators

• Sponsor: Institute of Liver and Biliary Sciences, India
• Investigators: Principal Investigator: Karthik T Ponnappan, DM, ILBS

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2010
• Primary Completion (Actual): December 31, 2016
• Study Completion (Actual): January 1, 2017

Study Registration Dates

• First Submitted: November 28, 2019
• First Submitted That Met QC Criteria: December 5, 2019
• First Posted (Actual): December 6, 2019

Study Record Updates

• Last Update Posted (Actual): December 10, 2019
• Last Update Submitted That Met QC Criteria: December 7, 2019
• Last Verified: November 1, 2019

More Information

Terms related to this study

• Keywords: liver transplantation; postoperative complications; neurological complications
• Additional Relevant MeSH Terms: Pathologic Processes; Postoperative Complications
• Other Study ID Numbers: ILBS - Liver Transplant-2

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No