Impact of Age and BMI on Liver Transplant Outcomes

The Impact of Advanced Age and High BMI on Short-term Outcomes in Live-donor Liver Transplant Recipients

Sponsors

Lead Sponsor: University of Pittsburgh

Source University of Pittsburgh
Brief Summary

Prospectively enrolled retrospective chart review and Liver Transplant database review to determine the modifiable and nonmodifiable risk factors specifically relating to Living Donor Liver Transplants. To observe the impact of age and BMI on graft outcomes and whether they impact the intraoperative management, post-operative length of stay, and complications.

Detailed Description

There has been a great deal of research into the characteristics of the donor for organ transplant, with older donors and those with more comorbidities having worse function once the organ is implanted. There has not been a great deal of research in the United States about the recipient's characteristic including age and BMI and the effects on donor organ function. With increasingly expanded criteria for organ recipients especially in the field of living donor organs the investigators plan to show the impact of older age and increased BMI on newly transplanted organs.

Overall Status Active, not recruiting
Start Date 2020-07-01
Completion Date 2021-06-30
Primary Completion Date 2021-06-30
Study Type Observational
Primary Outcome
Measure Time Frame
Graft Function 30 day 30 day
Mortality 1 year
Graft Survival 1 year 1 year
Secondary Outcome
Measure Time Frame
Perioperative Complications 30 day
Length of Stay- Total and ICU Up to 6 months
Duration of Intubation/Ventilation Up to 6 months
Postoperative Complications Up to 6 months
Blood Transfusion Up to 2 days
Vasoactive Medication Up to 2 days
Enrollment 700
Condition
Intervention

Intervention Type: Procedure

Intervention Name: Cadaveric

Description: Cadaveric Organ Transplant

Arm Group Label: Deceased Donor Liver Transplant Recipient

Intervention Type: Procedure

Intervention Name: Living Donor

Description: Living Donor Organ Transplant

Arm Group Label: Living Donor Liver Transplant Recipient

Eligibility

Sampling Method:

Non-Probability Sample

Criteria:

Inclusion Criteria: - All patients who received a liver transplant at UPMC- Montefiore Hospital Age> 18 Exclusion Criteria: - Excludes Children (<18 years old) as they do not receive their operation under the same protocols Lost to follow-up prior to 1 year Participation in alternate research protocol that significantly altered the care they received in the perioperative period that may make their inclusion skew results.

Gender:

All

Minimum Age:

18 Years

Maximum Age:

N/A

Healthy Volunteers:

No

Location
Facility: UPMC Montefiore
Location Countries

United States

Verification Date

2021-04-01

Responsible Party

Type: Principal Investigator

Investigator Affiliation: University of Pittsburgh

Investigator Full Name: Michael Trostler

Investigator Title: Liver Transplant Anesthesia Fellow

Keywords
Has Expanded Access No
Condition Browse
Arm Group

Label: Living Donor Liver Transplant Recipient

Description: Patients who have received a living donor liver transplant.

Label: Deceased Donor Liver Transplant Recipient

Description: Patients who have received either a Deceased by Circulatory Death or Deceased by Brain Death Liver Transplant

Patient Data No
Study Design Info

Observational Model: Case-Control

Time Perspective: Retrospective

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