Interrupting Prolonged Sitting With Periodic Interval Exercise: Effect on Postprandial Lipemia

Investigating the effects of interrupting various lengths of prolonged sitting with bike sprints on post prandial lipemia the next day. We will conduct three trials, one control, one with two-hour sitting intervals (total of 4 bouts of bike sprints) and one with 6-hour sitting intervals I total of two bouts of bike sprints). A milkshake high fat tolerance test will be conducted the next day and whole body fat oxidation as well as triglyceride area under the curve will be measured every hour for the duration of the 6-hour test.

Study Overview

• Status: Unknown
• Conditions: Hypertriglyceridemia; Sedentary Behavior
• Intervention / Treatment: Behavioral: Interrupting Prolonged Sitting with Periodic Interval Exercise: Effect on Postprandial Lipemia

• Study Type: Interventional
• Enrollment (Anticipated): 15
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Rebecca braden, BS; Phone Number: 4422156656; Email: rebecca.braden@utexas.edu
• Study Contact Backup: Name: Edward Coyle, PhD; Phone Number: 512 471 8596; Email: coyle@austin.utexas.edu

Study Locations

• United States
  • Texas
    • Austin, Texas, United States, 78705
      • University of Texas, Austin
      • Contact: Edward Coyle, PhD; Phone Number: 512 471 8596; Email: coyle@austin.utexas.edu
      • Contact: Rebecca Braden, BS; Phone Number: 442-215-6656; Email: rebecca.braden@utexas.edu

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 65 years (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Inactive or recreational healthy adults aged 18-65 years old.

Exclusion Criteria:

• Lactose intolerance, cardiovascular or metabolic diagnoses, medications for cardiovascular or metabolic diagnoses, orthopedic issues barring cycling.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: RANDOMIZED
• Interventional Model: CROSSOVER
• Masking: NONE

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
NO_INTERVENTION: Control group-no exercise; A no-exercise control. Must maintain <4,500 steps per day for 3 consecutive days followed by a high fat tolerance test on day 4.
EXPERIMENTAL: Exercise intervention 1; Two consecutive days of <4,500 steps per day followed by an intervention day on day 3. Intervention day consists of interrupting 8-hour sit with bike sprint protocol every 2 hours. Participants must aim to maintain <2,500 steps on intervention day. A high fat tolerance test will be performed the following day on day 4.	Behavioral: Interrupting Prolonged Sitting with Periodic Interval Exercise: Effect on Postprandial Lipemia; This is a behavioral intervention designed to determine the effect of breaking up prolonged bouts of sitting every 2 hours and every 6 hours with 5 sets of 4 second bouts of maximum effort bicycle ergometer accelerations compared to sitting alone on the blood triglyceride response and whole body fat oxidation after a high fat meal.
EXPERIMENTAL: Exercise intervention 2; Two consecutive days of <4,500 steps per day followed by an intervention day. Intervention day consists of interrupting 8-hour sit with bike sprint protocol every 6 hours. Participants must aim to maintain <2,500 steps on intervention day. A high fat tolerance test will be performed the following day on day 4.	Behavioral: Interrupting Prolonged Sitting with Periodic Interval Exercise: Effect on Postprandial Lipemia; This is a behavioral intervention designed to determine the effect of breaking up prolonged bouts of sitting every 2 hours and every 6 hours with 5 sets of 4 second bouts of maximum effort bicycle ergometer accelerations compared to sitting alone on the blood triglyceride response and whole body fat oxidation after a high fat meal.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Triglyceride area under the curve	Blood measurements baseline and every hour during a high fat tolerance test.	6 hour long high fat tolerance test

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Whole body fat oxidation	Expired gas collection and measurement of expired gas concentrations in mass spectrometer, baseline and every two hours during high fat tolerance test.	10 min, baseline, 2 hours post ingestion of shake, 4 hours, 6 hours.

Collaborators and Investigators

• Sponsor: University of Texas at Austin

Study record dates

Study Major Dates

• Study Start (ANTICIPATED): January 1, 2020
• Primary Completion (ANTICIPATED): May 1, 2020
• Study Completion (ANTICIPATED): May 1, 2020

Study Registration Dates

• First Submitted: January 21, 2020
• First Submitted That Met QC Criteria: January 21, 2020
• First Posted (ACTUAL): January 27, 2020

Study Record Updates

• Last Update Posted (ACTUAL): January 27, 2020
• Last Update Submitted That Met QC Criteria: January 21, 2020
• Last Verified: January 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Metabolic Diseases; Lipid Metabolism Disorders; Hyperlipidemias; Dyslipidemias; Hypertriglyceridemia
• Other Study ID Numbers: 2019-10-0091

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No