- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04242316
Effects of Mirror Therapy and Bilateral Arm Training on Hemiparetic Upper Extremity in Patients With Chronic Stroke
January 22, 2020 updated by: The Hong Kong Polytechnic University
The aim of this study included (1) to compare the effectiveness of mirror therapy (MT) and bimanual arm training (BAT) in improving motor and functional performance of hemiplegic upper extremity for adults with chronic stroke; (2) to examine whether recruitment of the mirror neurons, as reflected in mu rhythm suppression, mediates recognition of the mirror illusion in pre/post MT, as compared to BAT without a mirror in clients with chronic stroke, as compared to healthy participants.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Mirror Therapy (MT) appeared to have beneficial effects on the recovery of distal function of the hemiplegic hand in the evidence recently, however, it is not known whether the incongruent visual feedback induced by mirror in bilateral arm training (BAT) is beneficial to the motor performance of upper extremity than without the mirror in patients with chronic stroke.
This study aimed to compare the effectiveness of MT and bimanual arm training (BAT) in improving motor and functional performance of hemiplegic upper extremity for adults with chronic stroke.
Participants with chronic stroke were recruited by convenience sampling from a convalescent hospital and self-help groups in the community in Hong Kong.
Participants were randomly assigned to the MT group or BAT group and participated in a 6-week upper limb training programme which consisted of two 45-minute training sessions per week.
Both kinds of training were equivalent to each other except that there was a mirror used in the MT group.
Main outcome measures were upper extremity motor and functional tests, and grip strength.
Participants were evaluated at baseline, post-treatment and 3-month follow-up.
EEG was assessed before and after the training in a group of stroke patients and healthy controls, in order to evaluate the recruitment of the mirror neurons, as reflected in mu rhythm suppression.
Study Type
Interventional
Enrollment (Actual)
101
Phase
- Not Applicable
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 80 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- neurological condition with unilateral hemiparesis;
- a Functional Test of Hemiplegic Upper Extremity (FTHUE) score between levels 2 to 6;
- chronic stroke with onset of neurological condition more than 6 months previously;
- ability to understand and follow simple verbal instructions;
- ability to participate in a therapy session lasting at least 30 minutes;
- community ambulant with or without aids.
Exclusion Criteria:
Individuals with severe neglect and severe spasticity (Modified Ashworth Scale >3) would be excluded.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Mirror Therapy
Patients performed customized bimanual upper limb exercises with a mirror.
They can observe the mirror visual feedback of their non-paretic hand during the movements.
|
Patients performed customized bimanual upper limb exercises with graded level of difficulty based on the patient's individual levels of upper limb functioning according to the 7 levels of the FTHUE and each level consisted of 5 standardized table-top tasks.
The patients practiced the movements with the unaffected hand (including the shoulder, elbow, wrist, and hand).
While watching the reflection of the unaffected hand in the mirror, the patient was then asked to moving the affected hand at the same time to synchronize the movement with the reflection of the unaffected hand.
If the patient was unable to move the hand, a therapist would passively assist the movement of the affected hand so as to synchronize it with the reflection of the unaffected hand.
|
Active Comparator: Bilateral arm training
Patients performed customized bimanual upper limb exercises without a mirror.
|
Patients performed customized bimanual upper limb exercises with graded level of difficulty based on the patient's individual levels of upper limb functioning according to the 7 levels of the FTHUE and each level consisted of 5 standardized table-top tasks, but without a mirror.
The patients can take a direct view of their paretic hand.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Fugl-Meyer assessment (FMA)
Time Frame: Baseline
|
FMA-UE is a standard upper limb motor impairment assessment for stroke survivors.
FMA-UE assesses voluntary movement, reflex activity, grasp and coordination.
|
Baseline
|
Fugl-Meyer assessment (FMA)
Time Frame: After 6-week
|
FMA-UE is a standard upper limb motor impairment assessment for stroke survivors.
FMA-UE assesses voluntary movement, reflex activity, grasp and coordination.
|
After 6-week
|
Fugl-Meyer assessment (FMA)
Time Frame: 3-month after the completion of training
|
FMA-UE is a standard upper limb motor impairment assessment for stroke survivors.
FMA-UE assesses voluntary movement, reflex activity, grasp and coordination.
|
3-month after the completion of training
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Action Research Arm Test (ARAT)
Time Frame: Baseline
|
ARAT is a standard upper limb functional performance assessment for stroke survivors.
ARAT assesses a patient's ability to handle objects differing in size, weight and shape.
ARAT consists of 19 items grouped into four subscales: grasp, grip, pinch, and gross movement.
|
Baseline
|
Action Research Arm Test (ARAT)
Time Frame: After 6-week
|
ARAT is a standard upper limb functional performance assessment for stroke survivors.
ARAT assesses a patient's ability to handle objects differing in size, weight and shape.
ARAT consists of 19 items grouped into four subscales: grasp, grip, pinch, and gross movement.
|
After 6-week
|
Action Research Arm Test (ARAT)
Time Frame: 3-month after the completion of training
|
ARAT is a standard upper limb functional performance assessment for stroke survivors.
ARAT assesses a patient's ability to handle objects differing in size, weight and shape.
ARAT consists of 19 items grouped into four subscales: grasp, grip, pinch, and gross movement.
|
3-month after the completion of training
|
Wolf Motor Function Test (WMFT)
Time Frame: Baseline
|
WMFT assesses the functional limitation of upper limb after a neurological condition.
This test evaluates both strength (2 items) and function-based task performance (15 items).
|
Baseline
|
Wolf Motor Function Test (WMFT)
Time Frame: After 6-week
|
WMFT assesses the functional limitation of upper limb after a neurological condition.
This test evaluates both strength (2 items) and function-based task performance (15 items).
|
After 6-week
|
Wolf Motor Function Test (WMFT)
Time Frame: 3-month after the completion of training
|
WMFT assesses the functional limitation of upper limb after a neurological condition.
This test evaluates both strength (2 items) and function-based task performance (15 items).
|
3-month after the completion of training
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Mu rhythm suppression generated in the sensorimotor cortex
Time Frame: Baseline
|
Electroencephalographical assessment for cortical activation induced by mirror visual feedback.
|
Baseline
|
Mu rhythm suppression generated in the sensorimotor cortex
Time Frame: 6-week
|
Electroencephalographical assessment for cortical activation induced by mirror visual feedback.
|
6-week
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
January 1, 2014
Primary Completion (Actual)
January 1, 2017
Study Completion (Actual)
January 1, 2019
Study Registration Dates
First Submitted
January 22, 2020
First Submitted That Met QC Criteria
January 22, 2020
First Posted (Actual)
January 27, 2020
Study Record Updates
Last Update Posted (Actual)
January 27, 2020
Last Update Submitted That Met QC Criteria
January 22, 2020
Last Verified
January 1, 2020
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- HSEARS20121012008
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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