French Register Of Patients With Hemopathy Eligible For CAR-T Cell Treatment (DESCAR-T)

March 2, 2026 updated by: The Lymphoma Academic Research Organisation

This study is a registry including prospective and retrospective data on all patients who have been presented in a Multidisciplinary tumor board or RCP to be eligible for CAR-T cell treatment.

Study Overview

Status

Recruiting

Conditions

Hematopathology Eligible or CAR-t Cell Treatment

Study Type

Observational

Enrollment (Estimated)

5000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Name: Karine Danno
Phone Number: +33 (04) 72 66 93 33
Email: descar-t@lysarc.org

Study Locations

France
- - Amiens, France
    - Recruiting
    - CHU d'Amiens - Hôpital Sud
    - Contact:
      
      Magalie JORIS, MD
      
      Phone Number: +33 (0)3 22 45 60 00
      
      Email: joris.magalie@chu-amiens.fr
  - Angers, France
    - Recruiting
    - CHU Angers
    - Contact:
      
      Aline TANGUY-SCHMIDT, MD
      
      Email: alschmidt@chu-angers.fr
  - Besançon, France
    - Recruiting
    - CHRU Besançon - Hôpital Minjoz
    - Contact:
      
      Adrien CHAUCHET, MD
  - Brest, France
    - Recruiting
    - CHU de Brest - Hôpital du Morvan
    - Contact:
      
      Adrian TEMPESCUL, MD
      
      Email: adrian.tempescul@chu-brest.fr
  - Caen, France
    - Recruiting
    - Institut d'Hématologie de Basse Normandie
    - Contact:
      
      Ghandi DAMAJ, Pr
      
      Email: damaj-gl@chu-caen.fr
  - Clermont-Ferrand, France
    - Recruiting
    - CHU d'Estaing
    - Contact:
      
      Jacques-Olivier BAY, Pr
      
      Phone Number: +33 (0)4 73 75 00 65
      
      Email: jobay@chu-clermontferrand.fr
  - Créteil, France
    - Recruiting
    - APHP - Hopital Henri Mondor
    - Contact:
      
      Fabien LE BRAS, MD
      
      Phone Number: +33 (0)1 49 83 65 05
      
      Email: fabien.le-bras@aphp.fr
  - Dijon, France
    - Recruiting
    - CHU de Dijon
    - Contact:
      
      Olivier CASASNOVAS, MD
      
      Phone Number: +33 (0)3 80 29 50 41
      
      Email: olivier.casasnovas@chu-dijon.fr
  - La Tronche, France
    - Recruiting
    - CHU de Grenoble
    - Contact:
      
      Sylvain CARRAS, MD
      
      Phone Number: +33 (0)4 76 76 57 55
      
      Email: scarras@chu-grenoble.fr
  - Lille, France
    - Recruiting
    - CHRU de Lille - Hôpital Claude Hurriez
    - Contact:
      
      Ibrahim YAKOUB-AGHA, Pr
      
      Phone Number: +33 (0)3 20 44 42 84
      
      Email: ibrahim.yakoubagha@chru-lille.fr
  - Limoges, France
    - Recruiting
    - Hopital Dupuytren
    - Contact:
      
      Julie ABRAHAM, MD
      
      Phone Number: +33 (0)5 55 05 66 51
      
      Email: julie.abraham@chu-limoges.fr
  - Lyon, France
    - Recruiting
    - Centre Léon Bérard
  - Lyon, France
    - Recruiting
    - Institut d'Hématologie et d'Oncologie Pédiatrique (IHOP)
    - Contact:
      
      Yves BERTRAND, Pr
      
      Email: yves.bertrand@ihope.fr
  - Marseille, France
    - Recruiting
    - Hôpital de la timone
    - Contact:
      
      Arthur STERIN, MD
      
      Email: arthur.sterin@aph-m.fr
  - Marseille, France
    - Recruiting
    - Institut Paoli Calmette
    - Contact:
      
      Aude Collignon, MD
  - Montpellier, France
    - Recruiting
    - CHU de Montpellier
    - Contact:
      
      Guillaume CARTRON, Pr
      
      Phone Number: +33(0)4 67 33 67 33
      
      Email: guillaume.cartron@orange.fr
  - Nantes, France
    - Recruiting
    - CHU de Nantes - Hotel Dieu
    - Contact:
      
      Thomas GASTINNE, MD
      
      Phone Number: +33 (0)2 40 08 33 02
      
      Email: thomas.gastinne@chu-nantes.fr
  - Nice, France
    - Recruiting
    - CHU de Nice
    - Contact:
      
      Michaël LOSCHI, MD
      
      Phone Number: +33 (0)4 92 03 90 25
      
      Email: loschi.m@chu-nice.fr
  - Paris, France
    - Recruiting
    - APHP - Hôpital Cochin
    - Contact:
      
      Jérémie ZERBIT, Dr
      
      Email: jeremie.zerbit@aphp.fr
  - Paris, France
    - Recruiting
    - APHP - Hôpital Saint Antoine
    - Contact:
      
      Mohamad MOHTY, Pr
      
      Phone Number: +33 (0)1 49 28 26 20
      
      Email: mohamad.mohty@inserm.fr
  - Paris, France
    - Recruiting
    - APHP - Hôpital Necker
    - Contact:
      
      Olivier HERMINE, Pr
      
      Phone Number: +33 (0)1 44 49 51 98
      
      Email: olivier.hermine@aphp.fr
  - Paris, France
    - Recruiting
    - APHP - Hopital Saint Louis
    - Contact:
      
      Catherine THIEBLEMONT, Pr
      
      Phone Number: +33 (0) 1 42 49 98 37
      
      Email: catherine.thieblemont@aphp.fr
  - Paris, France
    - Recruiting
    - APHP - Hôpital La Pitié Salpêtrière
    - Contact:
      
      Sylvain CHOQUET, MD
      
      Phone Number: +33 (0)1 42 16 28 26
      
      Email: sylvain.choquet@aphp.fr
  - Paris, France
    - Recruiting
    - APHP - Hôpital Universitaire Robert Debré
    - Contact:
      
      André BARUCHEL, Pr
      
      Phone Number: +33 (0)1 40 03 53 88
      
      Email: andre.baruchel@aphp.fr
  - Pessac, France
    - Recruiting
    - Centre Francois Magendie
    - Contact:
      
      Kamal BOUABDALLAH, MD
      
      Phone Number: +33 (0)5 57 65 65 11
      
      Email: kamal.bouabdallah@chu-bordeaux.fr
  - Pierre-Bénite, France
    - Recruiting
    - Centre Hospitalier Lyon sud
    - Contact:
      
      Emmanuel BACHY, Pr
      
      Phone Number: +33 (0)4 78 86 43 01
      
      Email: emmanuel.bachy@chu-lyon.fr
  - Poitiers, France
    - Recruiting
    - Hôpital de la Milétrie - CHU de Poitiers
    - Contact:
      
      Xavier LELEU, Pr
      
      Phone Number: +33 (0)5 49 44 46 89
      
      Email: xavier.leleu@chu-poitiers.fr
  - Rennes, France
    - Recruiting
    - CHU De Rennes - Hôpital Pontchaillou
    - Contact:
      
      Thierry LAMY-DE-LA-CHAPELLE, Pr
      
      Phone Number: +33 (0)2 99 28 42 91
      
      Email: thierry.lamy.de.la.chapelle@chu-rennes.fr
  - Rouen, France
    - Recruiting
    - Centre Henri Becquerel
    - Contact:
      
      Fabrice JARDIN, Pr
      
      Phone Number: +33 (0)2 32 08 24 65
      
      Email: fabrice.jardin@chb.unicancer.fr
  - Rouen, France
    - Recruiting
    - CHU de Rouen Normandie
    - Contact:
      
      Nimrod BUCHBINDER, MD
      
      Email: Nimrod.Buchbinder@chu-rouen.fr
  - Saint-Priest-en-Jarez, France
    - Recruiting
    - Institut de Cancérologie Hématologie Universitaire de Saint Etienne
    - Contact:
      
      Ludovic FOUILLET, MD
      
      Email: ludovic.fouillet@icloire.fr
  - Strasbourg, France
    - Recruiting
    - ICANS (Institut de Cancérologie Strasbourg Europe)
    - Contact:
      
      Blandine GUFFROY, MD
      
      Email: b.guffroy@icans.eu
  - Toulouse, France
    - Recruiting
    - Institut Universitaire du Cancer - Oncopole Toulouse (IUCT-O)
    - Contact:
      
      Pierre BORIES, MD
      
      Phone Number: +33 (0)5 31 15 65 14
      
      Email: bories.pierre@iuct-oncopole.fr
  - Tours, France
    - Recruiting
    - CHU Bretonneau
    - Contact:
      
      Emmanuel GYAN, MD
      
      Phone Number: +33 (0)2 47 47 37 12
      
      Email: e.gyan@chu-tours.fr
  - Vandœuvre-lès-Nancy, France
    - Recruiting
    - CHU Brabois
    - Contact:
      
      Marie-Thérèse RUBIO, Pr
      
      Phone Number: +33 (0)3 83 15 32 82
      
      Email: m.rubio@chru-nancy.fr
    - Principal Investigator:
      
      Marie-Thérèse RUBIO, Pr
    - Principal Investigator:
      
      Cécile POCHON, MD
  - Villejuif, France
    - Recruiting
    - Gustave Roussy Cancer Campus
    - Contact:
      
      Cristina CASTILLA LLORENTE, MD
      
      Phone Number: +33 (0)1 42 11 42 39
      
      Email: cristina.castilla-llorente@gustaveroussy.fr

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

1 second to 99 years (Child, Adult, Older Adult)

Accepts Healthy Volunteers

Sampling Method

Non-Probability Sample

Study Population

Patient eligible for a treatment with CAR-T for an hematological malignancy

Description

Inclusion Criteria:

Retrospective inclusion :

Patient treated with CAR-T from 1 July 2018 under temporary authorization (ATU) or covered by French health insurance system (under post-ATU or MA) in a qualified center before activation of this register in this center
If the patient is alive, the patient has been informed of the collection and use of their data, and the patient has not opposed this use. If the patient has died, the patient did not opposed the use of their data while alive

Prospective inclusion :

Patient eligible for a treatment with CAR-T for an hematological malignancy which is covered by French health insurance (for ATUs / post-ATUs or MA), or as part of a clinical trial with the same indication, after the activation of this register in this center.
Patient whose CAR-T indication has been validated during a multidisciplinary tumor board (RCP) of a qualified center, according to the ministerial order of 8 August 2019
Patient deemed eligible for a treatment with CAR-T after a medical exam performed in a qualified center according to the ministerial order of 8 August 2019
If the patient is alive, the patient has been informed of the collection and use of their data, and the patient has not opposed this use. If the patient has died, the patient did not opposed the use of their data while alive.

Exclusion Criteria Patient not registered with the social security in France

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Observational Models: Cohort
Time Perspectives: Other

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
overall survival from eligibility Time Frame: 15 years	15 years
Overall survival from administration Time Frame: 15 years	15 years
complete response rate Time Frame: 15 years	15 years
Progression free survival Time Frame: 15 years	15 years
Duration of response Time Frame: 15 years	15 years
Delays between patient eligibility and CAR-T treatment Time Frame: 15 years	15 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

The Lymphoma Academic Research Organisation

Collaborators

Bristol-Myers Squibb

Novartis

Gilead Sciences

Investigators

Principal Investigator: Steven LE GOUILL, Pr, Institut CURIE
Principal Investigator: Roch HOUOT, Pr, CHU Pontchaillou

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 19, 2019

Primary Completion (Estimated)

December 19, 2038

Study Completion (Estimated)

December 19, 2038

Study Registration Dates

First Submitted

March 27, 2020

First Submitted That Met QC Criteria