Post Exercise Substrate Oxidation, Appetite and Energy Intakes in Overweight/Obese Postmenopausal Women (EScAPE) (EScAPE)

Comparison of Acute Cycling Modalities on Enjoyment, Post Exercise Substrate Oxidation, Appetite and Energy Intakes Over 24h in Postmenopausal Women With Overweight or Obesity

High-intensity interval exercise (HIIT), as compared to moderate intensity continuous training (MICT), is a time-efficient strategy to decrease total and abdominal fat mass (FM). However, the mechanisms underlying such adaptations are not yet elucidated and research are still needed to establish the optimal HIIT according to subject characteristics. The aim of this study was to compare acute HIIE and MICE cycling exercises on enjoyment, post-exercise substrate oxidation, appetite and energy intakes over 24h in postmenopausal women with overweight or obesity. It is hypothesized that compared with the traditional MICE, HIIE could favor greater enjoyment, higher 2h-post-exercise fat oxidation and a similar energy intakes over 24h despite different post-exercise appetite perceptions.

Study Overview

• Status: Completed
• Conditions: Overweight; Postmenopausal
• Intervention / Treatment: Other: Moderate Intensity Continuous Exercise; Other: High-Intensity Interval Exercise (1); Other: High-Intensity Interval Exercise (2)

Detailed Description

The aim of this study was to compare acute HIIE and MICE cycling exercises on enjoyment, post-exercise substrate oxidation, and appetite and energy intakes over 24h in postmenopausal women with overweight or obesity.

Using a randomized crossover design, 12 postmenopausal women completed 3 cycling exercises at 6-days intervals:

i) Moderate Intensity Continuous Exercise (MICE) which consisted of 35 min cycling at 60-65% theorical Peak Heart Rate (thPHR) ii) High Intensity Interval Exercise 1 (HIIE 1) 60 cycles of speeding up for 8 s at 80-90%thPHR followed by pedaling slowly for 12 s (20min) iii) High Intensity Interval Exercise 2 (HIIE 2) which consisted of repeated 10 x 1min at 80-90% thPHR followed by pedaling slowly for 1min.

Substrate oxidation (CHO and FAT) were measured at rest and 2h- post exercise. Enjoyment, perceived exertion and appetite were recorded and post-exercise energy intakes were assessed over 24h.

• Study Type: Interventional
• Enrollment (Actual): 12
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Allier
    • Bellerive-sur-Allier, Allier, France, 03321
      • CREPS Auvergne Rhône-Alpes / Vichy

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years to 75 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• postmenopausal women (spontaneous amenorrhea for at least 12 months)
• with overweight or obesity (BMI > 25 kg/m2 and ≤ 40 kg/m2)

Exclusion Criteria:

• medical contraindications to intense physical activity,
• painful joints,
• taking hormone replacement therapy,
• taking B-blockers.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

Experimental: Women with overweight or obesity

Other: Moderate Intensity Continuous Exercise; Participant completed a moderate intensity continuous cycling exercise (MICE) during 35 min at 60-65% thPHRmax; Other: High-Intensity Interval Exercise (1); Participant completed a high-intensity interval cycling exercise (HIIE 1) during 20min with 60 cycles of speeding up for 8s and pedaling slowly for 12s at 80-90% thPHRmax; Other: High-Intensity Interval Exercise (2); Participant completed a high-intensity interval cycling exercise (HIIE 2) during 20min with 10 x 1-min bouts at 80-90% thPHRmax, separated by 1-min recovery bouts

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Post-exercise (2 hours) CHO and FAT oxidation	CHO and FAT oxidation were measured after each modality with indirect calorimetry during 2 hours post-exercise	2 hours post-exercise

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Enjoyment	Perceive enjoyment evaluated with Physical Activity Enjoyment Scale (PAES) for each modalities. The total scores of PAES are between 18 and 126 with the higher scores indicating greater enjoyment.	Immediately post-exercise
Rate Perceive Exertion (RPE)	RPE evaluated with adapted Borg's Scale during exercise for each modalities	During exercise (5-10-15 and 20 minutes for HIIE1 and 2 ; 9-18-27 and 35 minutes for MICE) which corresponds at 25-50-75 and 100% of bout completion.
Appetite	The validated 100 millimeters Visual Analogue Scale (VAS) was used to assess the subjective appetite at 4 time points: before, immediately post-exercise, 60 minutes and 120 minutes post-exercise. This scale comprised four questions anchored with words representing the opposing extreme states of desire to eat, hunger, fullness and prospective food consumption. The score of each question are between 0 and 100.	Before, immediately post-exercise, 60 minutes and 120 minutes post-exercise
Energy intakes	Estimated energy intakes using dietary questionnaires	24 hours post-exercise

Collaborators and Investigators

• Sponsor: Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
• Collaborators: CREPS Auvergne Rhône-Alpes / Vichy
• Investigators: Principal Investigator: Claire Morel, Dr, CREPS Auvergne Rhône-Alpes / Vichy

Study record dates

Study Major Dates

• Study Start (Actual): November 1, 2019
• Primary Completion (Actual): April 1, 2020
• Study Completion (Actual): April 1, 2020

Study Registration Dates

• First Submitted: April 21, 2020
• First Submitted That Met QC Criteria: April 24, 2020
• First Posted (Actual): April 27, 2020

Study Record Updates

• Last Update Posted (Actual): April 28, 2020
• Last Update Submitted That Met QC Criteria: April 26, 2020
• Last Verified: April 1, 2020

More Information

Terms related to this study

• Keywords: Appetite; Postmenopausal women; High-intensity interval exercise; Enjoyment; Exercise Modalities; CHO and FAT oxidation; Energy intakes
• Additional Relevant MeSH Terms: Body Weight; Overweight
• Other Study ID Numbers: IRB00012476-2020-24-03-50

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No